Protein: MUS81
Crossover junction endonuclease MUS81 (EC 3.1.22.-) (MMS and UV-sensitive protein 81)

Gene: MUS81
Organism: Saccharomyces cerevisiae S288C
Interactions: 106
UniProt ID: Q04149

Gene Ontology (top 5):
GO:0000712 - resolution of meiotic recombination intermediates
GO:0000727 - double-strand break repair via break-induced replication
GO:0003677 - DNA binding
GO:0004857 - enzyme inhibitor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

796776

MMS4
Crossover junction endonuclease MMS4

15

0

Small-scale

0.934

High

740006

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

3

1

Small-scale

0.664

High

746352

RAD54
DNA repair and recombination protein RAD54

3

2

Small-scale

0.661

High

805956

CRP1
Cruciform DNA-recognizing protein 1 [Cleaved into: CRP1 short N-terminal subpeptide; CRP1 short C-terminal subpeptide]

1

0

Small-scale

0.537

High

382322

H4
Histone H4

1

1

High-throughput

0.536

High

646528

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.536

High

1045071

YRA1
RNA annealing protein YRA1

1

1

High-throughput

0.536

High

1045070

SLX4
Structure-specific endonuclease subunit SLX4

1

0

Small-scale

0.529

High

453997

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

486790

CDC16
Anaphase-promoting complex subunit CDC16

1

0

High-throughput

0.513

High

637276

PWP1
Periodic tryptophan protein 1

1

0

High-throughput

0.513

High

744771

MG101
Mitochondrial genome maintenance protein MGM101

1

0

High-throughput

0.513

High

763369

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.513

High

807135

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.513

High

813306

FHP
Flavohemoprotein

1

0

High-throughput

0.513

High

816896

NUG1
Nuclear GTP-binding protein NUG1

1

0

High-throughput

0.513

High

817551

ICP55
Intermediate cleaving peptidase 55

1

0

High-throughput

0.513

High

823727

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

828317

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.513

High

830174

NOP2
25S rRNA

1

0

High-throughput

0.513

High

850011

LOC1
60S ribosomal subunit assembly/export protein LOC1

1

0

High-throughput

0.513

High

918813

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.513

High

921163

H1
Histone H1

1

0

High-throughput

0.513

High

1045062

ERB1
Ribosome biogenesis protein ERB1

1

0

High-throughput

0.513

High

1045064

YM71
NADP-dependent 3-hydroxy acid dehydrogenase

1

0

High-throughput

0.513

High

557764

SRS2
ATP-dependent DNA helicase SRS2

1

0

Small-scale

0.504

High

689762

FEN1
Flap endonuclease 1

1

1

Small-scale

0.501

High

822971

RFC4
Replication factor C subunit 4

1

1

Small-scale

0.501

High

823143

RFC2
Replication factor C subunit 2

1

1

Small-scale

0.501

High

518123

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.500

High

531396

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.500

High

621405

METK2
S-adenosylmethionine synthase 2

1

1

High-throughput

0.500

High

667120

CG22
G2/mitotic-specific cyclin-2

1

0

High-throughput

0.486

High

818050

LSM4
LSM complex subunit LSM4

1

0

High-throughput

0.486

High

448472

RAD52
DNA repair and recombination protein RAD52

1

0

Small-scale

0.480

High

586486

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.480

High

1045065

ESC2
Protein ESC2

1

0

Small-scale

0.480

High

403647

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.479

High

645526

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.479

High

676319

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.479

High

817946

IMB4
Importin subunit beta-4

1

0

High-throughput

0.479

High

948645

ACT
Actin

1

0

High-throughput

0.479

High

509708

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

725939

PSK1
Serine/threonine-protein kinase PSK1

1

1

High-throughput

0.479

High

849774

RIM15
Serine/threonine-protein kinase RIM15

1

1

High-throughput

0.479

High

1045063

GAL83
SNF1 protein kinase subunit beta-3

1

1

High-throughput

0.479

High

1045066

RRP44
Exosome complex exonuclease DIS3

1

1

High-throughput

0.479

High

471432

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.458

High

570814

ABF1
ARS-binding factor 1

1

0

High-throughput

0.458

High

582254

AMPD
AMP deaminase

1

0

High-throughput

0.458

High

584324

DPOD
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

736045

SP110
Spindle pole body component 110

1

0

High-throughput

0.458

High

761139

NOT4
General negative regulator of transcription subunit 4

1

0

High-throughput

0.458

High

781727

SA190
SIT4-associating protein SAP190

1

0

High-throughput

0.458

High

804787

NADE
Glutamine-dependent NAD(+) synthetase

1

0

High-throughput

0.458

High

825270

YIK8
Putative zinc metalloproteinase YIL108W

1

0

High-throughput

0.458

High

826806

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

829792

MAD1
Spindle assembly checkpoint component MAD1

1

0

High-throughput

0.458

High

836537

T2FA
Transcription initiation factor IIF subunit alpha

1

0

High-throughput

0.458

High

1034907

SKO1
CRE-binding bZIP protein SKO1

1

0

High-throughput

0.458

High

1045068

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

0

High-throughput

0.458

High

1045075

RKM4
Ribosomal lysine N-methyltransferase 4

1

0

High-throughput

0.458

High

546160

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

819711

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

1045060

GYL1
Probable GTPase-activating protein GYL1

1

1

High-throughput

0.437

High

1045073

GYP5
GTPase-activating protein GYP5

1

1

High-throughput

0.437

High

525052

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

925419

EFM6
Protein-lysine N-methyltransferase EFM6

2

0

High-throughput

0.307

High

864745

BBC1
Myosin tail region-interacting protein MTI1

1

0

High-throughput

0.282

High

358421

ADH2
Alcohol dehydrogenase 2

1

0

High-throughput

0.279

Low

368924

SYMC
Methionine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.279

Low

582513

SEC23
Protein transport protein SEC23

1

0

High-throughput

0.279

Low

738252

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

0

High-throughput

0.279

Low

782436

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.279

Low

843269

KRI1
Protein KRI1

1

0

High-throughput

0.279

Low

924621

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.279

Low

1045067

NOP12
Nucleolar protein 12

1

0

High-throughput

0.279

Low

814265

RV167
Reduced viability upon starvation protein 167

1

0

Small-scale

0.265

Low

368745

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.261

Low

394880

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.261

Low

408586

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

425146

OTC
Ornithine carbamoyltransferase

1

0

High-throughput

0.261

Low

644835

CLH
Clathrin heavy chain

1

0

High-throughput

0.261

Low

661689

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.261

Low

823446

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

836883

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.261

Low

865064

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.261

Low

926278

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.261

Low

515322

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.249

Low

570301

RS17B
Small ribosomal subunit protein eS17B

1

0

High-throughput

0.249

Low

600714

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.249

Low

634278

NUP1
Nucleoporin NUP1

1

0

High-throughput

0.249

Low

780641

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.249

Low

799673

TPS3
Trehalose synthase complex regulatory subunit TPS3

1

0

High-throughput

0.249

Low

801984

KIC1
Serine/threonine-protein kinase KIC1

1

0

High-throughput

0.249

Low

816603

GEA2
ARF guanine-nucleotide exchange factor 2

1

0

High-throughput

0.249

Low

822483

PEP8
Carboxypeptidase Y-deficient protein 8

1

0

High-throughput

0.249

Low

925317

COG6
Conserved oligomeric Golgi complex subunit 6

1

0

High-throughput

0.249

Low

925463

HDA1
Histone deacetylase HDA1

1

0

High-throughput

0.249

Low

1045061

GRH1
GRASP65 homolog protein 1

1

0

High-throughput

0.249

Low

1045069

VPS54
Vacuolar protein sorting-associated protein 54

1

0

High-throughput

0.249

Low

1045072

BUG1
Binder of USO1 and GRH1 protein 1

1

0

High-throughput

0.249

Low

1045074

OSH2
Oxysterol-binding protein homolog 2

1

0

High-throughput

0.249

Low

1045076

VPS5
Vacuolar protein sorting-associated protein 5

1

0

High-throughput

0.249

Low

672457

STE50
Protein STE50

1

0

High-throughput

0.238

Low

1039162

YP108
Uncharacterized protein YPL108W

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025