Protein: HDA2
HDA1 complex subunit 2 (Histone deacetylase complex 1 subunit 2)

Gene: HDA2
Organism: Saccharomyces cerevisiae S288C
Interactions: 126
UniProt ID: Q06629

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

925465

HDA1
Histone deacetylase HDA1

6

0

Small-scale

0.904

High

1056284

HDA3
HDA1 complex subunit 3

6

0

Small-scale

0.904

High

682943

MSH2
DNA mismatch repair protein MSH2

3

0

High-throughput

0.637

High

755302

NUF2
Kinetochore protein NUF2

3

0

High-throughput

0.617

High

1046712

SPC24
Kinetochore protein SPC24

3

0

High-throughput

0.617

High

1056295

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.589

High

636478

ACE2
Metallothionein expression activator

2

0

High-throughput

0.570

High

829794

MAD1
Spindle assembly checkpoint component MAD1

2

0

High-throughput

0.570

High

866069

NNF1
Kinetochore-associated protein NNF1

2

0

High-throughput

0.570

High

527780

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.552

High

546417

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.513

High

680092

CDC48
Cell division control protein 48

1

0

High-throughput

0.493

High

757908

UBX1
UBX domain-containing protein 1

1

0

High-throughput

0.493

High

555277

RAD50
DNA repair protein RAD50

1

0

High-throughput

0.486

High

1056296

BRE1
E3 ubiquitin-protein ligase BRE1

1

0

High-throughput

0.486

High

646091

KIN3
Serine/threonine-protein kinase KIN3

1

1

High-throughput

0.481

High

815069

SNF7
Vacuolar-sorting protein SNF7

1

1

High-throughput

0.481

High

823049

ATAD2
ATPase histone chaperone YTA7

1

1

High-throughput

0.481

High

865181

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

1

High-throughput

0.481

High

919526

AP18B
Clathrin coat assembly protein AP180B

1

1

High-throughput

0.481

High

1046226

VPS20
Vacuolar protein sorting-associated protein 20

1

1

High-throughput

0.481

High

656887

KC12
Casein kinase I homolog 2

1

0

High-throughput

0.480

High

740618

IME2
Meiosis induction protein kinase IME2/SME1

1

0

High-throughput

0.480

High

438337

NOT3
General negative regulator of transcription subunit 3

1

0

High-throughput

0.460

High

548730

RNA1
Ran GTPase-activating protein 1

1

0

High-throughput

0.460

High

626543

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.460

High

639516

RE107
Recombination protein 107

1

0

High-throughput

0.460

High

643667

SNF2
Transcription regulatory protein SNF2

1

0

High-throughput

0.460

High

725984

SWC3
SWR1-complex protein 3

1

0

High-throughput

0.460

High

736401

MET4
Transcriptional activator of sulfur metabolism MET4

1

0

High-throughput

0.460

High

748904

SWE1
Mitosis inhibitor protein kinase SWE1

1

0

High-throughput

0.460

High

749732

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

750790

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.460

High

753043

SPC29
Spindle pole component 29

1

0

High-throughput

0.460

High

780985

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.460

High

797323

SP381
Pre-mRNA-splicing factor SPP381

1

0

High-throughput

0.460

High

802534

SYSM
Serine--tRNA ligase, mitochondrial

1

0

High-throughput

0.460

High

806875

SKN7
Transcription factor SKN7

1

0

High-throughput

0.460

High

817031

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

817769

TSC11
Target of rapamycin complex 2 subunit TSC11

1

0

High-throughput

0.460

High

822214

NACB2
Nascent polypeptide-associated complex subunit beta-2

1

0

High-throughput

0.460

High

823228

MED3
Mediator of RNA polymerase II transcription subunit 3

1

0

High-throughput

0.460

High

823255

SEC9
Protein transport protein SEC9

1

0

High-throughput

0.460

High

836342

BNI1
Protein BNI1

1

0

High-throughput

0.460

High

836596

SPR3
Sporulation-regulated protein 3

1

0

High-throughput

0.460

High

844491

GZF3
Protein GZF3

1

0

High-throughput

0.460

High

863960

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

0

High-throughput

0.460

High

864218

YJ41B
Transposon Ty4-J Gag-Pol polyprotein

1

0

High-throughput

0.460

High

864681

SNX4
Sorting nexin-4

1

0

High-throughput

0.460

High

864695

VPS53
Vacuolar protein sorting-associated protein 53

1

0

High-throughput

0.460

High

865851

EAF6
Chromatin modification-related protein EAF6

1

0

High-throughput

0.460

High

917184

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.460

High

917736

KNL1
Outer kinetochore KNL1 complex subunit SPC105

1

0

High-throughput

0.460

High

919127

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.460

High

924903

AF9
Protein AF-9 homolog

1

0

High-throughput

0.460

High

1018328

CTR9
RNA polymerase-associated protein CTR9

1

0

High-throughput

0.460

High

1038165

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.460

High

1042814

NHP10
Non-histone protein 10

1

0

High-throughput

0.460

High

1055774

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.460

High

1055881

ARR1
Arsenical-resistance protein ARR1

1

0

High-throughput

0.460

High

1056298

SGO1
Shugoshin

1

0

High-throughput

0.460

High

1056299

YP216
Putative ISWI chromatin-remodeling complex subunit YPL216W

1

0

High-throughput

0.460

High

1056300

MDN1
Midasin

1

0

High-throughput

0.460

High

1056301

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.460

High

1056302

CENPH
Inner kinetochore subunit MCM16

1

0

High-throughput

0.460

High

1056303

GYP5
GTPase-activating protein GYP5

1

0

High-throughput

0.460

High

1056306

SKS1
Serine/threonine-protein kinase SKS1

1

0

High-throughput

0.460

High

708287

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

741134

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

0

High-throughput

0.458

High

812685

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

817199

CHZ1
Histone H2A.Z-specific chaperone CHZ1

1

0

High-throughput

0.458

High

525270

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

727341

HS104
Heat shock protein 104

1

1

High-throughput

0.445

High

779582

LHS1
Heat shock protein 70 homolog LHS1

1

2

High-throughput

0.439

High

780887

STB6
Protein STB6

1

1

High-throughput

0.439

High

814128

HPH2
Protein HPH2

1

1

High-throughput

0.439

High

858527

STB2
Protein STB2

1

1

High-throughput

0.439

High

1056307

HPH1
Protein HPH1

1

1

High-throughput

0.439

High

1035123

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.438

High

393391

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.426

High

752778

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

1025046

NUM1
Nuclear migration protein NUM1

2

0

High-throughput

0.310

High

858267

FAR3
Factor arrest protein 3

2

0

Small-scale

0.300

High

678286

ARE1
Sterol O-acyltransferase 1

1

0

High-throughput

0.251

Low

735680

SMY1
Kinesin-related protein SMY1

1

0

High-throughput

0.251

Low

743885

YEF3
Uncharacterized protein YEL043W

1

0

High-throughput

0.251

Low

751881

SLA2
Protein SLA2

1

0

High-throughput

0.251

Low

753148

NIP80
Protein NIP100

1

0

High-throughput

0.251

Low

758154

CASP
Protein CASP

1

0

High-throughput

0.251

Low

758490

SEG2
Eisosome protein SEG2

1

0

High-throughput

0.251

Low

779807

DYHC
Dynein heavy chain, cytoplasmic

1

0

High-throughput

0.251

Low

780433

RT22
Ribosome assembly protein RSM22, mitochondrial

1

0

High-throughput

0.251

Low

782597

DAD2
DASH complex subunit DAD2

1

0

High-throughput

0.251

Low

782950

JNM1
Nuclear migration protein JNM1

1

0

High-throughput

0.251

Low

792674

AP2A
AP-2 complex subunit alpha

1

0

High-throughput

0.251

Low

796376

FL2D
Protein MUM2

1

0

High-throughput

0.251

Low

797197

ATG14
Autophagy-related protein 14

1

0

High-throughput

0.251

Low

803314

ETP1
RING finger protein ETP1

1

0

High-throughput

0.251

Low

804919

LAM4
Membrane-anchored lipid-binding protein LAM4

1

0

High-throughput

0.251

Low

806365

KOG1
Target of rapamycin complex 1 subunit KOG1

1

0

High-throughput

0.251

Low

809235

END3
Actin cytoskeleton-regulatory complex protein END3

1

0

High-throughput

0.251

Low

813862

MBO1
Gamma tubulin complex adapter SPC72

1

0

High-throughput

0.251

Low

849854

BUD27
Bud site selection protein 27

1

0

High-throughput

0.251

Low

864335

NET1
Nucleolar protein NET1

1

0

High-throughput

0.251

Low

864587

YJE9
Uncharacterized protein YJL049W

1

0

High-throughput

0.251

Low

864833

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.251

Low

866199

SGM1
Protein SGM1

1

0

High-throughput

0.251

Low

871098

CCM1
Mitochondrial 15S rRNA processing factor CCM1

1

0

High-throughput

0.251

Low

875336

TBCA
Tubulin-specific chaperone A

1

0

High-throughput

0.251

Low

918774

NNF2
Protein NNF2

1

0

High-throughput

0.251

Low

919265

YG3A
Uncharacterized protein YGR130C

1

0

High-throughput

0.251

Low

999498

DID2
Vacuolar protein-sorting-associated protein 46

1

0

High-throughput

0.251

Low

999594

HSK3
DASH complex subunit HSK3

1

0

High-throughput

0.251

Low

1040697

SVL3
Styryl dye vacuolar localization protein 3

1

0

High-throughput

0.251

Low

1044553

SPC19
DASH complex subunit SPC19

1

0

High-throughput

0.251

Low

1045082

SHE9
Sensitive to high expression protein 9, mitochondrial

1

0

High-throughput

0.251

Low

1049972

IVY1
Protein IVY1

1

0

High-throughput

0.251

Low

1052324

ENT2
Epsin-2

1

0

High-throughput

0.251

Low

1054076

FMP27
Protein FMP27, mitochondrial

1

0

High-throughput

0.251

Low

1054432

SEC10
Exocyst complex component SEC10

1

0

High-throughput

0.251

Low

1054680

MMR1
Mitochondrial MYO2 receptor-related protein 1

1

0

High-throughput

0.251

Low

1056297

YL031
Putative uncharacterized protein YLR031W

1

0

High-throughput

0.251

Low

1056304

BBP1
Spindle pole component BBP1

1

0

High-throughput

0.251

Low

1056305

ERP3
Protein ERP3

1

0

High-throughput

0.251

Low

518399

IF4A
ATP-dependent RNA helicase eIF4A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025