Protein: GCH1
GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I)

Gene: GCH1, FOL2
Organism: Saccharomyces cerevisiae S288C
Interactions: 49
UniProt ID: P51601

Gene Ontology (top 5):
GO:0003934 - GTP cyclohydrolase I activity
GO:0005525 - GTP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006729 - tetrahydrobiopterin biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

904462

GCH1
GTP cyclohydrolase 1

1

7

High-throughput

0.656

High

393032

HSP82
ATP-dependent molecular chaperone HSP82

3

0

High-throughput

0.606

High

904466

IMA1
Importin subunit alpha

2

0

High-throughput

0.594

High

524549

HSP71
Heat shock protein SSA1

2

3

High-throughput

0.584

High

819252

SSB2
Ribosome-associated molecular chaperone SSB2

2

3

High-throughput

0.552

High

670922

SIS1
Protein SIS1

2

0

High-throughput

0.547

High

545549

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.536

High

656541

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.536

High

448194

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.513

High

649510

UBA1
Ubiquitin-activating enzyme E1 1

1

0

High-throughput

0.513

High

666698

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

0

High-throughput

0.513

High

808792

LYS1
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

1

0

High-throughput

0.513

High

904465

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

High-throughput

0.513

High

904475

DUF1
DUB-associated factor 1

1

0

High-throughput

0.513

High

734700

IMB3
Importin subunit beta-3

1

1

High-throughput

0.508

High

509642

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

904464

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.493

High

798451

NTM1
Alpha N-terminal protein methyltransferase 1

1

0

High-throughput

0.486

High

904473

USB1
U6 snRNA phosphodiesterase 1

1

0

High-throughput

0.486

High

441191

KAPA
cAMP-dependent protein kinase type 1

1

0

High-throughput

0.480

High

574595

YAK1
Dual specificity protein kinase YAK1

1

0

High-throughput

0.480

High

865502

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

0

High-throughput

0.480

High

430886

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

High-throughput

0.458

High

594465

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

679872

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

707633

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

747949

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

818679

YRF12
Y' element ATP-dependent helicase protein 1 copy 2

1

0

High-throughput

0.458

High

820378

RIO2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.458

High

820802

CCS1
Superoxide dismutase 1 copper chaperone

1

0

High-throughput

0.458

High

904467

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

904468

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

904470

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

904472

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

481688

HSP73
Heat shock protein SSA3

1

3

High-throughput

0.445

High

527165

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

741969

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

804817

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

1

High-throughput

0.437

High

904474

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

1

High-throughput

0.437

High

806978

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.426

High

844418

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.426

High

904469

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.279

Low

738673

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.265

Low

904463

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.261

Low

795099

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

812286

ATC3
Phospholipid-transporting ATPase DRS2

1

0

High-throughput

0.249

Low

812483

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

904471

YP251
Putative uncharacterized protein YPL251W

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025