Protein: KU80
ATP-dependent DNA helicase II subunit 2 (EC 3.6.4.12) (ATP-dependent DNA helicase II subunit Ku80) (High affinity DNA-binding factor subunit 2) (Yeast Ku80)

Gene: KU80, YKU80
Organism: Saccharomyces cerevisiae S288C
Interactions: 143
UniProt ID: Q04437

Gene Ontology (top 5):
GO:0000723 - telomere maintenance
GO:0000724 - double-strand break repair via homologous recombination
GO:0000725 - recombinational repair
GO:0000781 - chromosome, telomeric region
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

745451

KU70
ATP-dependent DNA helicase II subunit 1

12

8

Small-scale

0.975

High

550693

SIR4
Regulatory protein SIR4

5

1

Small-scale

0.722

High

603106

EST1
Telomere elongation protein EST1

3

1

Small-scale

0.640

High

1046629

DNLI4
DNA ligase 4

1

6

Small-scale

0.621

High

602628

PHO85
Cyclin-dependent protein kinase PHO85

2

7

Small-scale

0.619

High

1046622

NHEJ1
Non-homologous end-joining protein 1

2

1

Small-scale

0.595

High

963706

H3
Histone H3

2

7

Small-scale

0.584

High

399377

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

1

High-throughput

0.536

High

417174

VDAC1
Non-selective voltage-gated ion channel 1

1

4

High-throughput

0.536

High

452758

ADR1
Regulatory protein ADR1

1

3

High-throughput

0.536

High

671097

SIS1
Protein SIS1

1

4

High-throughput

0.536

High

738075

MKK2
MAP kinase kinase MKK2/SSP33

1

7

High-throughput

0.536

High

776646

DEF1
RNA polymerase II degradation factor 1

1

3

High-throughput

0.536

High

802768

RRP3
ATP-dependent rRNA helicase RRP3

1

5

High-throughput

0.536

High

810892

TCPG
T-complex protein 1 subunit gamma

1

3

High-throughput

0.536

High

812117

DHH1
ATP-dependent RNA helicase DHH1

1

6

High-throughput

0.536

High

816393

HSP7E
Heat shock protein SSC3, mitochondrial

1

4

High-throughput

0.536

High

823649

TCPE
T-complex protein 1 subunit epsilon

1

5

High-throughput

0.536

High

1028027

ACAC
Acetyl-CoA carboxylase

1

2

High-throughput

0.536

High

647833

RFA1
Replication factor A protein 1

1

5

Small-scale

0.534

High

590717

HSP26
Heat shock protein 26

2

3

High-throughput

0.533

High

688767

RFA2
Replication factor A protein 2

1

5

Small-scale

0.515

High

471435

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.513

High

631998

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.513

High

665204

DPB2
DNA polymerase epsilon subunit B

1

0

High-throughput

0.513

High

736206

YBT1
ATP-dependent bile acid permease

1

0

High-throughput

0.513

High

798087

SLX1
Structure-specific endonuclease subunit SLX1

1

0

High-throughput

0.513

High

801815

YHJ3
Uncharacterized protein YHR033W

1

0

High-throughput

0.513

High

865645

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.513

High

1046633

TFC7
Transcription factor tau 55 kDa subunit

1

0

High-throughput

0.513

High

367117

ATPB
ATP synthase subunit beta, mitochondrial

1

7

High-throughput

0.500

High

393302

HSP82
ATP-dependent molecular chaperone HSP82

1

4

High-throughput

0.500

High

408348

GAL1
Galactokinase

1

1

High-throughput

0.500

High

452969

ATPA
ATP synthase subunit alpha, mitochondrial

1

7

High-throughput

0.500

High

453784

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.500

High

470587

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.500

High

531401

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.500

High

592491

VATB
V-type proton ATPase subunit B

1

7

High-throughput

0.500

High

607788

HXKG
Glucokinase-1

1

1

High-throughput

0.500

High

626880

HSP60
Heat shock protein 60, mitochondrial

1

3

High-throughput

0.500

High

676333

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.500

High

680046

CDC48
Cell division control protein 48

1

4

High-throughput

0.500

High

763495

MDJ1
DnaJ homolog 1, mitochondrial

1

3

High-throughput

0.500

High

865066

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.500

High

948647

ACT
Actin

1

1

High-throughput

0.500

High

1033886

PRS8
26S proteasome regulatory subunit 8 homolog

1

1

High-throughput

0.500

High

1046634

RUVB2
RuvB-like protein 2

1

4

High-throughput

0.500

High

456453

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

1

High-throughput

0.489

High

585651

STI1
Heat shock protein STI1

1

4

High-throughput

0.489

High

596827

ODPX
Pyruvate dehydrogenase complex protein X component, mitochondrial

1

1

High-throughput

0.489

High

705790

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

1

High-throughput

0.489

High

825478

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

3

High-throughput

0.489

High

834772

LST8
Target of rapamycin complex subunit LST8

1

2

High-throughput

0.489

High

920752

SULX
Putative sulfate transporter YPR003C

1

1

High-throughput

0.489

High

922115

COPA
Coatomer subunit alpha

1

2

High-throughput

0.489

High

923202

NOG2
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.489

High

1043592

CLU
Clustered mitochondria protein 1

1

2

High-throughput

0.489

High

1044260

WDR59
Maintenance of telomere capping protein 5

1

3

High-throughput

0.489

High

745532

MRE11
Double-strand break repair protein MRE11

1

1

Small-scale

0.481

High

918525

RSC1
Chromatin structure-remodeling complex subunit RSC1

1

13

Small-scale

0.481

High

599071

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.479

High

1046627

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.479

High

381253

H2B1
Histone H2B.1

1

10

High-throughput

0.479

High

381628

H2B2
Histone H2B.2

1

10

High-throughput

0.479

High

382329

H4
Histone H4

1

3

High-throughput

0.479

High

419500

H2A1
Histone H2A.1

1

9

High-throughput

0.479

High

419866

H2A2
Histone H2A.2

1

9

High-throughput

0.479

High

647217

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.479

High

739767

SPT16
FACT complex subunit SPT16

1

2

High-throughput

0.479

High

1046619

POB3
FACT complex subunit POB3

1

3

High-throughput

0.479

High

1046624

TERT
Telomerase reverse transcriptase

1

3

Small-scale

0.479

High

1046625

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.479

High

1046635

CMR1
DNA damage-binding protein CMR1

1

7

High-throughput

0.479

High

1046630

SMT3
Ubiquitin-like protein SMT3

1

3

Small-scale

0.470

High

1046636

SUS1
SAGA complex subunit SUS1

1

0

Small-scale

0.458

High

368749

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.457

High

386856

TBB
Tubulin beta chain

1

1

High-throughput

0.457

High

405141

LEU3
3-isopropylmalate dehydrogenase

1

3

High-throughput

0.457

High

425147

OTC
Ornithine carbamoyltransferase

1

1

High-throughput

0.457

High

484793

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.457

High

486305

TBA1
Tubulin alpha-1 chain

1

4

High-throughput

0.457

High

486516

TBA3
Tubulin alpha-3 chain

1

4

High-throughput

0.457

High

644838

CLH
Clathrin heavy chain

1

1

High-throughput

0.457

High

661692

MPCP
Mitochondrial phosphate carrier protein

1

3

High-throughput

0.457

High

671703

SCJ1
DnaJ-related protein SCJ1

1

4

High-throughput

0.457

High

676978

SRO9
RNA-binding protein SRO9

1

3

High-throughput

0.457

High

817951

IMB4
Importin subunit beta-4

1

2

High-throughput

0.457

High

856564

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

2

High-throughput

0.457

High

926281

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

2

High-throughput

0.457

High

1046631

HSP42
Heat shock protein 42

1

3

High-throughput

0.457

High

510798

HSP77
Import motor subunit, mitochondrial

1

4

High-throughput

0.445

High

525086

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

546202

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.445

High

554047

TCPA
T-complex protein 1 subunit alpha

1

3

High-throughput

0.445

High

742356

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

811034

TCPD
T-complex protein 1 subunit delta

1

5

High-throughput

0.445

High

708123

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

745869

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.437

High

361496

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.279

Low

446246

PHSG
Glycogen phosphorylase

1

0

High-throughput

0.279

Low

470042

GAL7
Galactose-1-phosphate uridylyltransferase

1

0

High-throughput

0.279

Low

613744

MET16
Phosphoadenosine phosphosulfate reductase

1

0

High-throughput

0.279

Low

645204

PSB4
Proteasome subunit beta type-4

1

0

High-throughput

0.279

Low

675262

PSB3
Proteasome subunit beta type-3

1

0

High-throughput

0.279

Low

738337

RPN12
26S proteasome regulatory subunit RPN12

1

0

High-throughput

0.279

Low

740532

SIP1
SNF1 protein kinase subunit beta-1

1

0

High-throughput

0.279

Low

743720

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.279

Low

751716

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.279

Low

782057

HFL1
Vacuole membrane protein HFL1

1

0

High-throughput

0.279

Low

793107

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.279

Low

808552

TEM1
Protein TEM1

1

0

High-throughput

0.279

Low

811681

DSS1
Exoribonuclease II, mitochondrial

1

0

High-throughput

0.279

Low

814038

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.279

Low

817538

MRX1
MIOREX complex component 1

1

0

High-throughput

0.279

Low

863226

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.279

Low

883390

APT1
Adenine phosphoribosyltransferase 1

1

0

High-throughput

0.279

Low

904469

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.279

Low

919657

YG5L
Uncharacterized protein YGR266W

1

0

High-throughput

0.279

Low

921472

SUCA
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

1026967

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.279

Low

1043351

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.279

Low

1043879

YMC0
Uncharacterized protein YML020W

1

0

High-throughput

0.279

Low

1045053

TSA2
Peroxiredoxin TSA2

1

0

High-throughput

0.279

Low

1046621

YM71
NADP-dependent 3-hydroxy acid dehydrogenase

1

0

High-throughput

0.279

Low

1046623

YL271
Uncharacterized protein YLR271W

1

0

High-throughput

0.279

Low

1046626

PUF3
mRNA-binding protein PUF3

1

0

High-throughput

0.279

Low

1046628

AVO1
Target of rapamycin complex 2 subunit AVO1

1

0

High-throughput

0.279

Low

1046632

PST2
Protoplast secreted protein 2

1

0

High-throughput

0.279

Low

394888

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.261

Low

450645

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.261

Low

555152

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.261

Low

585569

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.261

Low

613632

ADT2
ADP,ATP carrier protein 2

1

0

High-throughput

0.261

Low

673531

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.261

Low

709969

BMH1
Protein BMH1

1

0

High-throughput

0.261

Low

823447

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

836886

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.261

Low

1046620

SOV1
Protein SOV1, mitochondrial

1

0

High-throughput

0.261

Low

448334

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.249

Low

1043941

PML39
Pre-mRNA leakage protein 39

1

0

High-throughput

0.249

Low

1045003

LRS4
Monopolin complex subunit LRS4

1

0

Small-scale

0.249

Low

470623

AAP
Arginine attenuator peptide

1

0

High-throughput

0.238

Low

924726

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025