Protein: CBF1
Centromere-binding protein 1 (CBP-1) (Centromere promoter factor 1) (Centromere-binding factor 1)

Gene: CBF1
Organism: Saccharomyces cerevisiae S288C
Interactions: 43
UniProt ID: P17106

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000775 - chromosome, centromeric region
GO:0000776 - kinetochore
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

601991

CBF1
Centromere-binding protein 1

4

16

Small-scale

0.887

High

601998

MET4
Transcriptional activator of sulfur metabolism MET4

4

0

Small-scale

0.656

High

419349

H2A1
Histone H2A.1

1

3

Small-scale

0.647

High

602014

H3
Histone H3

1

7

Small-scale

0.647

High

601999

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

2

1

Small-scale

0.629

High

602010

DSN1
Kinetochore-associated protein DSN1

3

0

High-throughput

0.606

High

602011

MET28
Transcriptional activator of sulfur metabolism MET28

2

0

Small-scale

0.579

High

601994

RAD53
Serine/threonine-protein kinase RAD53

2

2

High-throughput

0.576

High

602004

CENPA
Histone H3-like centromeric protein CSE4

1

7

Small-scale

0.575

High

522970

HSP71
Heat shock protein SSA1

2

4

High-throughput

0.552

High

602002

CENPC
Inner kinetochore subunit MIF2

1

0

Small-scale

0.537

High

602003

CBF3C
Centromere DNA-binding protein complex CBF3 subunit C

1

0

Small-scale

0.537

High

602012

CBF3B
Centromere DNA-binding protein complex CBF3 subunit B

1

0

Small-scale

0.537

High

602001

RT04
Small ribosomal subunit protein uS2m

1

1

High-throughput

0.515

High

601993

DBF2
Cell cycle protein kinase DBF2

1

2

Small-scale

0.501

High

601996

PSK1
Serine/threonine-protein kinase PSK1

1

2

Small-scale

0.501

High

531441

RT01
Small ribosomal subunit protein mS43

1

0

High-throughput

0.493

High

602018

CENPO
Inner kinetochore subunit MCM21

1

0

Small-scale

0.486

High

547755

NHP6A
Non-histone chromosomal protein 6A

1

15

Small-scale

0.481

High

547846

NHP6B
Non-histone chromosomal protein 6B

1

15

Small-scale

0.481

High

602007

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

3

Small-scale

0.481

High

601997

DBF4
DDK kinase regulatory subunit DBF4

1

0

Small-scale

0.480

High

602006

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

10

Small-scale

0.479

High

602016

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

1

High-throughput

0.479

High

601992

AFT1
Iron-regulated transcriptional activator AFT1

1

0

Small-scale

0.460

High

594167

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

601995

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

602005

MCR1
NADH-cytochrome b5 reductase 2

1

0

High-throughput

0.458

High

602008

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

602017

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

602020

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

602021

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

602022

NKP1
Inner kinetochore subunit NKP1

1

0

High-throughput

0.458

High

525848

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

543725

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

602000

HSP7F
Heat shock protein homolog SSE1

1

7

High-throughput

0.445

High

602009

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

602015

ELOC
Elongin-C

1

1

Small-scale

0.439

High

602019

MET32
Transcriptional regulator MET32

1

0

Small-scale

0.426

High

550619

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.292

High

602013

DAM1
DASH complex subunit DAM1

1

0

Small-scale

0.261

Low

602023

VPS5
Vacuolar protein sorting-associated protein 5

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025