Protein: DBF4
DDK kinase regulatory subunit DBF4 (Dumbbell forming protein 4)

Gene: DBF4
Organism: Saccharomyces cerevisiae S288C
Interactions: 54
UniProt ID: P32325

Gene Ontology (top 5):
GO:0000775 - chromosome, centromeric region
GO:0000785 - chromatin
GO:0001100 - negative regulation of exit from mitosis
GO:0003688 - DNA replication origin binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

440915

CDC7
Cell division control protein 7

29

3

Small-scale

0.993

High

646333

RAD53
Serine/threonine-protein kinase RAD53

13

0

Small-scale

0.931

High

734248

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

7

0

Small-scale

0.923

High

734246

DBF4
DDK kinase regulatory subunit DBF4

4

0

Small-scale

0.833

High

364400

CDK1
Cyclin-dependent kinase 1

2

0

Small-scale

0.771

High

712952

MCM2
DNA replication licensing factor MCM2

7

3

Small-scale

0.749

High

734263

FKH1
Fork head protein homolog 1

1

1

Small-scale

0.740

High

734251

ORC2
Origin recognition complex subunit 2

3

0

Small-scale

0.632

High

734269

MCM6
DNA replication licensing factor MCM6

2

3

Small-scale

0.625

High

734266

FKH2
Fork head protein homolog 2

1

1

Small-scale

0.621

High

734247

MCM10
Minichromosome maintenance protein 10

2

1

Small-scale

0.602

High

734274

ORC3
Origin recognition complex subunit 3

2

0

Small-scale

0.593

High

721352

MCM4
DNA replication licensing factor MCM4

2

4

Small-scale

0.585

High

734265

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.559

High

713573

RIF1
Telomere length regulator protein RIF1

2

0

Small-scale

0.559

High

734264

ULP2
Ubiquitin-like-specific protease 2

1

0

Small-scale

0.529

High

734268

ORC5
Origin recognition complex subunit 5

1

0

Small-scale

0.529

High

734279

ATG17
Autophagy-related protein 17

1

0

High-throughput

0.518

High

734270

SLD3
DNA replication regulator SLD3

1

0

Small-scale

0.504

High

664420

MCM3
DNA replication licensing factor MCM3

1

3

Small-scale

0.501

High

713244

MCM5
Minichromosome maintenance protein 5

1

3

Small-scale

0.501

High

734254

MCM7
DNA replication licensing factor MCM7

1

1

Small-scale

0.501

High

419646

H2A2
Histone H2A.2

1

0

High-throughput

0.493

High

734261

RV167
Reduced viability upon starvation protein 167

1

0

High-throughput

0.493

High

734275

H3
Histone H3

1

0

High-throughput

0.493

High

601997

CBF1
Centromere-binding protein 1

1

0

Small-scale

0.480

High

684610

CDC20
APC/C activator protein CDC20

1

0

Small-scale

0.480

High

734267

COM1
DNA endonuclease SAE2

1

0

Small-scale

0.480

High

734272

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

Small-scale

0.480

High

734276

CENPP
Inner kinetochore subunit CTF19

1

0

Small-scale

0.480

High

734277

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

Small-scale

0.480

High

734280

CENPO
Inner kinetochore subunit MCM21

1

0

Small-scale

0.480

High

734283

CENPI
Inner kinetochore subunit CTF3

1

0

Small-scale

0.480

High

734257

RT107
Regulator of Ty1 transposition protein 107

1

1

Small-scale

0.479

High

734271

TOF1
Topoisomerase 1-associated factor 1

1

1

Small-scale

0.479

High

734250

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

Small-scale

0.460

High

734253

MSA2
Putative transcriptional activator MSA2

1

0

Small-scale

0.460

High

734256

ORC6
Origin recognition complex subunit 6

1

0

Small-scale

0.460

High

734282

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

Small-scale

0.460

High

706457

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

734255

MMS4
Crossover junction endonuclease MMS4

1

0

Small-scale

0.458

High

734258

REV7
DNA polymerase zeta processivity subunit

1

0

Small-scale

0.458

High

734260

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

734281

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

734249

HSP7F
Heat shock protein homolog SSE1

1

1

High-throughput

0.445

High

523321

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

544120

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

734273

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.426

High

734262

RPN3
26S proteasome regulatory subunit RPN3

1

0

High-throughput

0.269

Low

734278

ESC1
Silent chromatin protein ESC1

1

0

Small-scale

0.261

Low

734259

STN1
Protein STN1

1

0

Small-scale

0.251

Low

734252

ATO2
Ammonia transport outward protein 2

1

0

High-throughput

0.249

Low

700191

GAC1
Serine/threonine-protein phosphatase 1 regulatory subunit GAC1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025