Protein: CENPO
Inner kinetochore subunit MCM21 (CENP-O homolog) (Chromosome transmission fidelity protein 5) (Constitutive centromere-associated network protein MCM21) (Minichromosome maintenance protein 21)

Gene: CENPO, MCM21
Organism: Saccharomyces cerevisiae S288C
Interactions: 77
UniProt ID: Q06675

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000817 - COMA complex
GO:0008608 - attachment of spindle microtubules to kinetochore
GO:0034087 - establishment of mitotic sister chromatid cohesion
GO:0034508 - centromere complex assembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

807027

CENPN
Inner kinetochore subunit CHL4

3

0

Small-scale

0.784

High

797909

CENPU
Inner kinetochore subunit AME1

9

1

Small-scale

0.750

High

919466

CENPQ
Inner kinetochore subunit OKP1

5

1

Small-scale

0.721

High

1056403

CENPO
Inner kinetochore subunit MCM21

2

0

Small-scale

0.718

High

826869

DSN1
Kinetochore-associated protein DSN1

7

0

Small-scale

0.704

High

1038166

CENPP
Inner kinetochore subunit CTF19

6

0

Small-scale

0.702

High

1056415

CENPH
Inner kinetochore subunit MCM16

5

0

Small-scale

0.684

High

797130

CENPL
Inner kinetochore subunit IML3

4

0

High-throughput

0.648

High

779355

CENPA
Histone H3-like centromeric protein CSE4

4

0

Small-scale

0.643

High

866213

CENPK
Inner kinetochore subunit MCM22

3

0

High-throughput

0.622

High

1056422

CENPI
Inner kinetochore subunit CTF3

3

0

Small-scale

0.622

High

797351

INCE
Inner centromere protein SLI15

2

0

Small-scale

0.581

High

763753

CENPC
Inner kinetochore subunit MIF2

2

0

Small-scale

0.575

High

814094

MTW1
Kinetochore-associated protein MTW1

2

0

Small-scale

0.569

High

866070

NNF1
Kinetochore-associated protein NNF1

2

0

Small-scale

0.569

High

850697

CENPT
Inner kinetochore subunit CNN1

2

0

Small-scale

0.547

High

1053946

NKP2
Inner kinetochore subunit NKP2

1

0

High-throughput

0.493

High

602018

CBF1
Centromere-binding protein 1

1

0

Small-scale

0.486

High

910794

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.486

High

1046713

SPC24
Kinetochore protein SPC24

1

0

Small-scale

0.486

High

440974

CDC7
Cell division control protein 7

1

0

Small-scale

0.480

High

734280

DBF4
DDK kinase regulatory subunit DBF4

1

0

Small-scale

0.480

High

817032

SPC25
Kinetochore protein SPC25

1

0

Small-scale

0.460

High

1056414

RIO1
Serine/threonine-protein kinase RIO1

1

0

Small-scale

0.460

High

755303

NUF2
Kinetochore protein NUF2

1

0

Small-scale

0.458

High

795810

SHE1
Mitotic spindle-associated protein SHE1

1

0

Small-scale

0.458

High

824875

NDC80
Kinetochore protein NDC80

1

0

Small-scale

0.458

High

917737

KNL1
Outer kinetochore KNL1 complex subunit SPC105

1

0

Small-scale

0.458

High

917922

YBP2
YAP1-binding protein 2

1

0

Small-scale

0.458

High

1044273

FIN1
Filament protein FIN1

1

0

Small-scale

0.458

High

1046594

ZWINT
Outer kinetochore KNL1 complex subunit KRE28

1

0

High-throughput

0.458

High

1056420

NKP1
Inner kinetochore subunit NKP1

1

0

High-throughput

0.458

High

1056410

RBX1
RING-box protein HRT1

1

0

High-throughput

0.438

High

1056411

NSL1
Kinetochore-associated protein NSL1

1

0

High-throughput

0.426

High

1039051

IMA1
Importin subunit alpha

1

0

High-throughput

0.282

High

1043845

NSE5
Non-structural maintenance of chromosome element 5

1

0

High-throughput

0.282

High

752051

PRP18
Pre-mRNA-splicing factor 18

1

0

High-throughput

0.269

Low

826091

ULP2
Ubiquitin-like-specific protease 2

1

0

Small-scale

0.261

Low

708295

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

918901

RRP46
Exosome complex component RRP46

1

0

High-throughput

0.249

Low

1056413

PSH1
RING finger protein PSH1

1

0

Small-scale

0.249

Low

370482

ATIF
F(1)-ATPase inhibitor IF(1), mitochondrial

1

0

High-throughput

0.238

Low

453084

COX9
Cytochrome c oxidase subunit 9, mitochondrial

1

0

High-throughput

0.238

Low

602146

SPO12
Sporulation-specific protein 12

1

0

High-throughput

0.238

Low

803043

YHE2
Putative uncharacterized protein YHL042W

1

0

High-throughput

0.238

Low

805932

CHS7
Chitin synthase export chaperone

1

0

High-throughput

0.238

Low

806424

PTH
Peptidyl-tRNA hydrolase

1

0

High-throughput

0.238

Low

816107

YEH8
Uncharacterized protein YEL068C

1

0

High-throughput

0.238

Low

817169

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

0

High-throughput

0.238

Low

817250

EDC2
Enhancer of mRNA-decapping protein 2

1

0

High-throughput

0.238

Low

817673

YER4
Uncharacterized protein YER084W

1

0

High-throughput

0.238

Low

824896

YIO1
Putative uncharacterized protein YIL141W

1

0

High-throughput

0.238

Low

830243

RMRP
Ribonuclease MRP protein subunit SNM1

1

0

High-throughput

0.238

Low

831890

RS29B
Small ribosomal subunit protein uS14B

1

0

High-throughput

0.238

Low

849878

YFB5
Uncharacterized protein YFL015C

1

0

High-throughput

0.238

Low

850764

YFM4
Uncharacterized protein YFR054C

1

0

High-throughput

0.238

Low

871087

ECL1
Extender of the chronological lifespan protein 1

1

0

High-throughput

0.238

Low

916918

YGY9
Putative uncharacterized protein YGL239C

1

0

High-throughput

0.238

Low

918249

YG1C
Uncharacterized protein YGR018C

1

0

High-throughput

0.238

Low

918357

CAX4
Dolichyldiphosphatase

1

0

High-throughput

0.238

Low

1018183

YD455
Putative uncharacterized protein YDR455C

1

0

High-throughput

0.238

Low

1040611

PAU10
Seripauperin-10

1

0

High-throughput

0.238

Low

1056404

YD050
Putative uncharacterized protein YDL050C

1

0

High-throughput

0.238

Low

1056405

PBP4
Protein PBP4

1

0

High-throughput

0.238

Low

1056406

OPI6
Putative uncharacterized protein OPI6

1

0

High-throughput

0.238

Low

1056407

YD118
Putative uncharacterized protein YDL118W

1

0

High-throughput

0.238

Low

1056408

IRC19
Increased recombination centers protein 19

1

0

High-throughput

0.238

Low

1056409

YL037
Putative uncharacterized protein YLL037W

1

0

High-throughput

0.238

Low

1056412

YDL26
Putative uncharacterized protein YDL026W

1

0

High-throughput

0.238

Low

1056416

YD162
Putative uncharacterized protein YDL162C

1

0

High-throughput

0.238

Low

1056417

YD041
Putative uncharacterized protein YDL041W

1

0

High-throughput

0.238

Low

1056418

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.238

Low

1056419

NPC2
Phosphatidylglycerol/phosphatidylinositol transfer protein

1

0

High-throughput

0.238

Low

1056421

TMA17
Translation machinery-associated protein 17

1

0

High-throughput

0.238

Low

527787

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.232

Low

546429

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025