Protein: ERG1
Squalene epoxidase ERG1 (SE) (EC 1.14.14.17) (Ergosterol biosynthetic protein 1) (Squalene monooxygenase ERG1)

Gene: ERG1
Organism: Saccharomyces cerevisiae S288C
Interactions: 73
UniProt ID: P32476

Gene Ontology (top 5):
GO:0004506 - squalene monooxygenase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005811 - lipid droplet
GO:0006696 - ergosterol biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

737578

ERG25
C-4 methylsterol oxidase ERG25

2

1

Small-scale

0.632

High

672138

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

1

Small-scale

0.541

High

737153

ERG24
Delta(14)-sterol reductase ERG24

1

1

Small-scale

0.541

High

737568

ERG28
Ergosterol biosynthetic protein 28

1

0

Small-scale

0.529

High

737569

IMB4
Importin subunit beta-4

2

2

High-throughput

0.521

High

735304

ERG2
C-8 sterol isomerase ERG2

1

0

Small-scale

0.518

High

737559

SC61G
Protein transport protein SSS1

1

0

High-throughput

0.518

High

737580

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

0

Small-scale

0.518

High

737583

ERG5
C-22 sterol desaturase ERG5

1

0

Small-scale

0.518

High

526178

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.504

High

544170

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.504

High

735326

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

1

High-throughput

0.479

High

737577

SCS3
Acyl-coenzyme A diphosphatase SCS3

1

0

Small-scale

0.460

High

528568

CP51
Lanosterol 14-alpha demethylase CYP51

1

0

High-throughput

0.458

High

737557

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.458

High

737560

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.458

High

737563

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

737588

RTN1
Reticulon-like protein 1

1

0

Small-scale

0.458

High

737589

SEI1
Seipin

1

0

Small-scale

0.458

High

737594

GET3
ATPase GET3

1

0

Small-scale

0.458

High

737595

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.458

High

734635

IMB3
Importin subunit beta-3

1

3

High-throughput

0.437

High

737562

IMB2
Importin subunit beta-2

1

2

High-throughput

0.437

High

737590

IMB1
Importin subunit beta-1

1

2

High-throughput

0.437

High

523364

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.407

High

646115

NPR1
Nitrogen permease reactivator protein

1

1

High-throughput

0.407

High

737555

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.407

High

737570

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.407

High

579040

HSC82
ATP-dependent molecular chaperone HSC82

2

0

High-throughput

0.318

High

509452

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

0

Small-scale

0.298

High

737574

BUD27
Bud site selection protein 27

1

0

Small-scale

0.282

High

737579

MAL11
General alpha-glucoside permease

1

0

High-throughput

0.282

High

394350

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.279

Low

600668

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.279

Low

737564

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.279

Low

737572

SKP2
F-box protein SKP2

1

0

High-throughput

0.279

Low

409999

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

434925

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

441777

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

512321

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

512885

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

638984

VPS1
Vacuolar protein sorting-associated protein 1

1

0

High-throughput

0.249

Low

642351

MCK1
Protein kinase MCK1

1

0

High-throughput

0.249

Low

645333

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.249

Low

647048

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

661479

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

661596

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.249

Low

670468

SIS1
Protein SIS1

1

0

High-throughput

0.249

Low

674484

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

706504

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

721771

XPO1
Exportin-1

1

0

High-throughput

0.249

Low

726843

HS104
Heat shock protein 104

1

0

High-throughput

0.249

Low

734764

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

0

High-throughput

0.249

Low

737554

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.249

Low

737556

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

737558

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

737561

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

737565

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

737566

FHP
Flavohemoprotein

1

0

High-throughput

0.249

Low

737567

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.249

Low

737571

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

737573

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

737575

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.249

Low

737576

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

737581

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.249

Low

737582

BRE5
UBP3-associated protein BRE5

1

0

Small-scale

0.249

Low

737584

UFD2
E4 ubiquitin-protein ligase UFD2

1

0

High-throughput

0.249

Low

737585

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

Small-scale

0.249

Low

737586

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.249

Low

737587

ESP1
Separin

1

0

High-throughput

0.249

Low

737591

SUB2
ATP-dependent RNA helicase SUB2

1

0

High-throughput

0.249

Low

737592

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

737593

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025