HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: JAK3 (P52333)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Gene: JAK3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	15385932
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0009898 - cytoplasmic side of plasma membrane GO:0019221 - cytokine-mediated signaling pathway GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1124
+	Mm
		205468 SOCS3_MOUSE (1-225): 1.02e-54: 176: 96.89		JAK2_MOUSE (4-1101): 0: 891: 48.03
+	Mm
		1048195 YES_MOUSE (30-223): 1.21e-50: 174: 15.11		JAK2_MOUSE (4-1101): 0: 891: 48.03
+	Hs
		253369 SOCS4_HUMAN (16-221): 1.21e-53: 179: 20.29		JAK2_HUMAN (7-1101): 0: 881: 47.44
+	Hs
		155885 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		JAK2_HUMAN (7-1101): 0: 881: 47.44
+	Hs
		155888 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		ABL1_HUMAN (763-1102): 4.79e-95: 330: 29.45
+	Hs
		155151 SOCS7_HUMAN (13-221): 6.01e-51: 175: 24.17		YES_HUMAN (768-1109): 1.35e-97: 322: 29.16
+	Hs
		155896 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		YES_HUMAN (768-1109): 1.35e-97: 322: 29.16
+	Hs
		440300 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		FYN_HUMAN (815-1109): 4.95e-97: 320: 31.76
+	Hs
		155893 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		LCK_HUMAN (799-1110): 1.35e-96: 318: 30.99
+	Hs
		439905 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		LCK_HUMAN (799-1110): 1.35e-96: 318: 30.99
+	Hs
		155946 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		ERBB4_HUMAN (822-1104): 7.89e-88: 311: 36.62
+	Hs
		155925 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		BLK_HUMAN (800-1105): 9.04e-90: 299: 31.17
+	Mm
		73018 SOCS3_MOUSE (1-225): 1.02e-54: 176: 96.89		B1ASP2_MOUSE (768-1119): 5.67e-39: 160: 18.52
+	Hs
		155911 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		JAK1_HUMAN (761-1119): 2.17e-39: 161: 18.62
+	Hs
		363635 SOCS4_HUMAN (16-221): 1.21e-53: 179: 20.29		EGFR_HUMAN (527-780): 3.23e-18: 92.8: 24.34
+	Hs
		155889 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		EGFR_HUMAN (527-780): 3.23e-18: 92.8: 24.34
+	Hs
		362614 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		EGFR_HUMAN (527-780): 3.23e-18: 92.8: 24.34
+	Hs
		1060799 SOCS4_HUMAN (16-221): 1.21e-53: 179: 20.29		ACK1_HUMAN (525-790): 4.99e-16: 85.5: 29.14
+	Hs
		155890 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		ERBB2_HUMAN (527-780): 1.85e-13: 77.4: 25.00
+	Hs
		410529 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		ERBB2_HUMAN (527-780): 1.85e-13: 77.4: 25.00