HitPredict

Interactor 1: MMP2 (P08253)
72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX]
Gene: MMP2

Interactor 2: COIA1 (P39060)
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)]
Gene: COL18A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.687

Property	Details
Experiments	28514442, 33961781, 17615292, unassigned3799
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001525 - angiogenesis GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0009410 - response to xenobiotic stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 660 Hs			1 1754
+	Hs
		575781 MMP9_HUMAN (21-660): 0: 709: 44.17		COIA1_HUMAN (1-1754): 0: 1034: 99.60
+	Hs
		465926 MMP2_HUMAN (1-660): 0: 909: 100.00		CO1A2_HUMAN (794-1673): 2.15e-78: 288: 26.33
+	Hs
		384297 MMP2_HUMAN (1-660): 0: 909: 100.00		CO4A1_HUMAN (845-1672): 9.73e-55: 213: 21.94
+	Hs
		469654 MMP2_HUMAN (1-660): 0: 909: 100.00		CO4A2_HUMAN (871-1678): 1.04e-54: 213: 21.65
+	Hs
		384090 MMP2_HUMAN (1-660): 0: 909: 100.00		CO1A1_HUMAN (1109-1671): 8.11e-36: 151: 20.37
+	Hs
		438023 MMP2_HUMAN (1-660): 0: 909: 100.00		CO5A2_HUMAN (436-974): 6.06e-32: 139: 22.88
+	Hs
		469690 MMP2_HUMAN (1-660): 0: 909: 100.00		COMA1_HUMAN (1205-1671): 2.83e-31: 136: 20.17
+	Hs
		469677 MMP2_HUMAN (1-660): 0: 909: 100.00		CO4A6_HUMAN (1192-1673): 7.2e-26: 118: 18.92
+	Hs
		469655 MMP2_HUMAN (1-660): 0: 909: 100.00		COBA1_HUMAN (598-1065): 2.65e-25: 117: 28.66
+	Hs
		465931 MMP9_HUMAN (21-660): 0: 709: 44.17		CO1A2_HUMAN (794-1673): 2.15e-78: 288: 26.33
+	Hs
		384231 MMP2_HUMAN (1-660): 0: 909: 100.00		CO2A1_HUMAN (1384-1671): 1.87e-11: 71.6: 12.75
+	Hs
		384300 MMP9_HUMAN (21-660): 0: 709: 44.17		CO4A1_HUMAN (845-1672): 9.73e-55: 213: 21.94
+	Hs
		471579 MMP9_HUMAN (21-660): 0: 709: 44.17		CO4A2_HUMAN (871-1678): 1.04e-54: 213: 21.65
+	Hs
		384239 MMP9_HUMAN (21-660): 0: 709: 44.17		CO2A1_HUMAN (1384-1671): 1.87e-11: 71.6: 12.75
+	Hs
		465927 MMP3_HUMAN (18-229): 9.57e-89: 286: 44.95		CO1A2_HUMAN (794-1673): 2.15e-78: 288: 26.33
+	Hs
		399260 MMP1_HUMAN (34-233): 2.77e-82: 269: 41.51		CO1A2_HUMAN (794-1673): 2.15e-78: 288: 26.33
+	Hs
		465939 MMP8_HUMAN (42-233): 2.96e-77: 256: 40.89		CO1A2_HUMAN (794-1673): 2.15e-78: 288: 26.33
+	Hs
		465954 MMP16_HUMAN (50-229): 6.48e-69: 237: 35.78		CO1A2_HUMAN (794-1673): 2.15e-78: 288: 26.33
+	Hs
		465951 MMP14_HUMAN (51-519): 1.41e-66: 230: 21.05		CO1A2_HUMAN (794-1673): 2.15e-78: 288: 26.33
+	Hs
		465953 MMP15_HUMAN (41-229): 1.16e-65: 230: 33.80		CO1A2_HUMAN (794-1673): 2.15e-78: 288: 26.33