Protein: SASH1
SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein)

Gene: SASH1
Organism: Homo sapiens
Interactions: 53
UniProt ID: O94885

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0001965 - G-protein alpha-subunit binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

167779

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

2

2

Small-scale

0.757

High

320385

CRKL
Crk-like protein

1

2

Small-scale

0.713

High

320376

1433T
14-3-3 protein theta

3

13

High-throughput

0.650

High

320379

1433B
14-3-3 protein beta/alpha

3

13

High-throughput

0.650

High

320390

1433G
14-3-3 protein gamma

3

13

High-throughput

0.650

High

320394

1433F
14-3-3 protein eta

3

13

High-throughput

0.650

High

320384

CRK
Adapter molecule crk

1

2

Small-scale

0.621

High

320413

ES8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2

1

1

Small-scale

0.621

High

177755

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

2

Small-scale

0.618

High

213744

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

2

Small-scale

0.618

High

320388

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

Small-scale

0.618

High

320392

1433Z
14-3-3 protein zeta/delta

2

13

High-throughput

0.611

High

320380

1433S
14-3-3 protein sigma

2

13

High-throughput

0.601

High

320411

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

0

Small-scale

0.589

High

320375

NCK1
SH2/SH3 adapter protein NCK1

1

0

High-throughput

0.586

High

320415

IRAK4
Interleukin-1 receptor-associated kinase 4

1

0

Small-scale

0.586

High

320406

CNKR1
Connector enhancer of kinase suppressor of ras 1

1

1

Small-scale

0.555

High

320393

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

1

Small-scale

0.552

High

320378

OAS2
2'-5'-oligoadenylate synthase 2

1

0

Small-scale

0.529

High

320407

MCRS1
Microspherule protein 1

1

0

Small-scale

0.529

High

320409

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

Small-scale

0.529

High

320377

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.517

High

320383

MUC18
Cell surface glycoprotein MUC18

1

0

High-throughput

0.517

High

320373

SKIL
Ski-like protein

1

0

High-throughput

0.486

High

320386

UTRN
Utrophin

1

1

Small-scale

0.481

High

320402

SYNE2
Nesprin-2

1

2

Small-scale

0.481

High

320404

JADE3
Protein Jade-3

1

1

Small-scale

0.481

High

320414

JADE2
E3 ubiquitin-protein ligase Jade-2

1

1

Small-scale

0.481

High

320391

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

176589

KIF3B
Kinesin-like protein KIF3B

1

0

Small-scale

0.460

High

220548

AKA10
A-kinase anchor protein 10, mitochondrial

1

0

Small-scale

0.460

High

320371

CCDB1
Cyclin-D1-binding protein 1

1

0

Small-scale

0.460

High

320381

CTNA1
Catenin alpha-1

1

0

Small-scale

0.460

High

320387

ARRB1
Beta-arrestin-1

1

0

Small-scale

0.460

High

320396

SNX1
Sorting nexin-1

1

0

Small-scale

0.460

High

320397

C1D
Nuclear nucleic acid-binding protein C1D

1

0

Small-scale

0.460

High

320399

RB12B
RNA-binding protein 12B

1

0

Small-scale

0.460

High

320400

EXOC8
Exocyst complex component 8

1

0

Small-scale

0.460

High

320401

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

1

0

Small-scale

0.460

High

320372

ESR1
Estrogen receptor

1

0

Small-scale

0.458

High

320374

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.458

High

320403

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.458

High

320408

MYD88
Myeloid differentiation primary response protein MyD88

1

0

Small-scale

0.458

High

320410

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

Small-scale

0.458

High

320416

XPO7
Exportin-7

1

0

High-throughput

0.458

High

320418

NEMO
NF-kappa-B essential modulator

1

0

Small-scale

0.458

High

320382

HD
Huntingtin

1

1

High-throughput

0.457

High

320398

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

0

High-throughput

0.426

High

320412

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

0

Small-scale

0.426

High

320395

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

Small-scale

0.391

High

320389

AFF1
AF4/FMR2 family member 1

1

0

Small-scale

0.251

Low

320405

SBP2L
Selenocysteine insertion sequence-binding protein 2-like

1

0

Small-scale

0.251

Low

320417

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025