Protein: CATD
Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain]

Gene: CATD, CTSD
Organism: Homo sapiens
Interactions: 146
UniProt ID: P07339

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0004190 - aspartic-type endopeptidase activity
GO:0004197 - cysteine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

354431

NAPSA
Napsin-A

3

1

High-throughput

0.861

High

456276

ES8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2

1

0

High-throughput

0.630

High

456197

SPB3
Serpin B3

1

1

High-throughput

0.618

High

456201

SPB5
Serpin B5

1

1

High-throughput

0.618

High

456251

TM192
Transmembrane protein 192

3

0

Small-scale

0.613

High

456248

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

2

High-throughput

0.584

High

456280

FBX6
F-box only protein 6

2

2

High-throughput

0.584

High

456296

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

1

Small-scale

0.561

High

456180

TAU
Microtubule-associated protein tau

2

0

Small-scale

0.560

High

456209

PPT1
Palmitoyl-protein thioesterase 1

2

0

Small-scale

0.559

High

66479

RASFA
Ras association domain-containing protein 10

1

1

High-throughput

0.536

High

296870

RASF9
Ras association domain-containing protein 9

1

2

High-throughput

0.536

High

450904

LDHB
L-lactate dehydrogenase B chain

1

1

High-throughput

0.536

High

456193

CALX
Calnexin

1

4

High-throughput

0.536

High

456208

VASP
Vasodilator-stimulated phosphoprotein

1

1

High-throughput

0.536

High

456228

CUL2
Cullin-2

1

5

High-throughput

0.536

High

456261

CUL5
Cullin-5

1

5

High-throughput

0.536

High

188785

TMPS2
Transmembrane protease serine 2

1

3

High-throughput

0.515

High

131669

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.515

High

456271

SPY4
Protein sprouty homolog 4

1

2

High-throughput

0.515

High

456183

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

456188

H2AX
Histone H2AX

1

0

High-throughput

0.513

High

456206

PCP4
Calmodulin regulator protein PCP4

1

0

High-throughput

0.513

High

456223

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

456225

ILK
Scaffold protein ILK

1

0

High-throughput

0.513

High

456237

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.513

High

456242

JADE1
Protein Jade-1

1

0

High-throughput

0.513

High

456263

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.513

High

456268

5NT1A
Cytosolic 5'-nucleotidase 1A

1

0

High-throughput

0.513

High

456281

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

185359

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

456247

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

1

3

Small-scale

0.501

High

179001

NPFF
Pro-FMRFamide-related neuropeptide FF

1

0

High-throughput

0.493

High

456204

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

0

High-throughput

0.493

High

456218

H31
Histone H3.1

1

0

High-throughput

0.493

High

456264

PGRP3
Peptidoglycan recognition protein 3

1

0

High-throughput

0.493

High

456221

RASF7
Ras association domain-containing protein 7

1

2

High-throughput

0.489

High

456267

SH23A
SH2 domain-containing protein 3A

1

1

High-throughput

0.489

High

456195

MK01
Mitogen-activated protein kinase 1

1

0

High-throughput

0.486

High

456236

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.486

High

456202

SYUA
Alpha-synuclein

1

0

Small-scale

0.480

High

141286

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

Small-scale

0.479

High

302327

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

High-throughput

0.479

High

352855

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.479

High

456174

INVO
Involucrin

1

1

High-throughput

0.479

High

456175

SAP
Prosaposin

1

3

Small-scale

0.479

High

456184

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

1

High-throughput

0.479

High

456185

VATB1
V-type proton ATPase subunit B, kidney isoform

1

1

High-throughput

0.479

High

456190

EFNA1
Ephrin-A1

1

1

High-throughput

0.479

High

456196

GRN
Progranulin

1

1

Small-scale

0.479

High

456198

CASPE
Caspase-14

1

1

High-throughput

0.479

High

456199

1433S
14-3-3 protein sigma

1

2

High-throughput

0.479

High

456205

LEG7
Galectin-7

1

1

High-throughput

0.479

High

456211

EFNA4
Ephrin-A4

1

1

High-throughput

0.479

High

456212

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

456214

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

456216

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

456217

1433Z
14-3-3 protein zeta/delta

1

2

Small-scale

0.479

High

456220

CCL20
C-C motif chemokine 20

1

3

Small-scale

0.479

High

456226

IKZF1
DNA-binding protein Ikaros

1

1

High-throughput

0.479

High

456227

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

456259

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

456269

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

456282

T106B
Transmembrane protein 106B

1

2

Small-scale

0.479

High

456290

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

456291

IKZF3
Zinc finger protein Aiolos

1

1

High-throughput

0.479

High

456292

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

2

Small-scale

0.479

High

456240

ZDH20
Palmitoyltransferase ZDHHC20

1

1

High-throughput

0.470

High

456246

GP141
Probable G-protein coupled receptor 141

1

1

High-throughput

0.470

High

407778

SHBG
Sex hormone-binding globulin

1

0

Small-scale

0.460

High

331948

KAT7
Histone acetyltransferase KAT7

1

0

High-throughput

0.458

High

362605

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

456178

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

456181

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

Small-scale

0.458

High

456187

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.458

High

456191

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

456213

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

456215

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.458

High

456232

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.458

High

456234

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

456243

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

456252

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

456255

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.458

High

456265

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

456270

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

456275

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.458

High

456279

ANLN
Anillin

1

0

High-throughput

0.458

High

456286

CALL5
Calmodulin-like protein 5

1

0

High-throughput

0.458

High

456287

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

0

High-throughput

0.458

High

456289

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

456294

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

456176

ELNE
Neutrophil elastase

1

2

Small-scale

0.457

High

141741

CCL21
C-C motif chemokine 21

1

3

Small-scale

0.445

High

421315

A4
Amyloid-beta precursor protein

1

2

Small-scale

0.445

High

456179

CCL3
C-C motif chemokine 3

1

3

Small-scale

0.445

High

456182

CCL4
C-C motif chemokine 4

1

3

Small-scale

0.445

High

456189

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.445

High

456203

VATA
V-type proton ATPase catalytic subunit A

1

2

High-throughput

0.445

High

456219

HBA
Hemoglobin subunit alpha

1

1

Small-scale

0.445

High

456241

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

456274

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.445

High

217723

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.437

High

456229

CUL4A
Cullin-4A

1

5

High-throughput

0.437

High

456230

PKP1
Plakophilin-1

1

1

High-throughput

0.437

High

456231

DX39B
Spliceosome RNA helicase DDX39B

1

2

High-throughput

0.437

High

456260

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

456262

KISSR
KiSS-1 receptor

1

1

Small-scale

0.437

High

456272

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.437

High

456273

RNF38
E3 ubiquitin-protein ligase RNF38

1

1

Small-scale

0.437

High

456210

GPC3
Glypican-3

1

0

High-throughput

0.426

High

456224

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.407

High

456278

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.279

Low

456244

ZN497
Zinc finger protein 497

1

0

High-throughput

0.278

Low

116891

I6L9I8
EPN3 protein

1

0

High-throughput

0.268

Low

456177

IG2R
Putative insulin-like growth factor 2-associated protein

1

0

High-throughput

0.268

Low

456194

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.268

Low

456222

KIF1A
Kinesin-like protein KIF1A

1

0

High-throughput

0.268

Low

456233

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.268

Low

456239

LCE2A
Late cornified envelope protein 2A

1

0

High-throughput

0.268

Low

456249

MOGT3
2-acylglycerol O-acyltransferase 3

1

0

High-throughput

0.268

Low

456253

SUMF2
Inactive C-alpha-formylglycine-generating enzyme 2

1

0

High-throughput

0.268

Low

456266

SYT3
Synaptotagmin-3

1

0

High-throughput

0.268

Low

456288

DLGP2
Disks large-associated protein 2

1

0

High-throughput

0.268

Low

456297

IRAG1
Inositol 1,4,5-triphosphate receptor associated 1

1

0

High-throughput

0.268

Low

456285

NLGN3
Neuroligin-3

1

0

Small-scale

0.265

Low

105139

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

370944

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

456186

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

456192

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

456200

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

456207

DNLI4
DNA ligase 4

1

0

High-throughput

0.249

Low

456235

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

456238

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

456245

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

456250

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.249

Low

456256

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

456257

POF1B
Protein POF1B

1

0

High-throughput

0.249

Low

456258

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.249

Low

456277

RANB3
Ran-binding protein 3

1

0

High-throughput

0.249

Low

456283

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

456284

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

456293

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

456295

PPME1
Protein phosphatase methylesterase 1

1

0

Small-scale

0.249

Low

188074

MOT5
Monocarboxylate transporter 5

1

0

High-throughput

0.232

Low

254743

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

456254

NCKX4
Sodium/potassium/calcium exchanger 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025