Protein: EXOS5
Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B)

Gene: EXOS5, EXOSC5
Organism: Homo sapiens
Interactions: 157
UniProt ID: Q9NQT4

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000791 - euchromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1447245

EXOS1
Exosome complex component CSL4

15

20

Small-scale

0.989

High

1384033

EXOS8
Exosome complex component RRP43

14

19

Small-scale

0.985

High

1447228

EXOS3
Exosome complex component RRP40

11

13

Small-scale

0.979

High

1137674

EXOS7
Exosome complex component RRP42

5

19

High-throughput

0.932

High

1353560

DI3L1
DIS3-like exonuclease 1

5

20

Small-scale

0.930

High

1118343

EXOS2
Exosome complex component RRP4

5

20

Small-scale

0.922

High

1446190

EXOS4
Exosome complex component RRP41

4

19

Small-scale

0.909

High

1054514

EXOS9
Exosome complex component RRP45

3

19

High-throughput

0.871

High

1209123

EXOS6
Exosome complex component MTR3

3

19

High-throughput

0.871

High

1447243

RRP44
Exosome complex exonuclease RRP44

2

20

Small-scale

0.776

High

1032253

EXOSX
Exosome complex component 10

7

12

Small-scale

0.747

High

1119079

C1D
Nuclear nucleic acid-binding protein C1D

5

4

High-throughput

0.720

High

1405168

MPH6
M-phase phosphoprotein 6

5

8

Small-scale

0.714

High

1447250

RBM7
RNA-binding protein 7

4

10

High-throughput

0.704

High

1447238

IKZF3
Zinc finger protein Aiolos

4

1

High-throughput

0.698

High

1447247

HBS1L
HBS1-like protein

4

5

Small-scale

0.694

High

1049016

REL
Proto-oncogene c-Rel

3

1

High-throughput

0.675

High

1107491

BIRC2
Baculoviral IAP repeat-containing protein 2

3

2

High-throughput

0.675

High

1117926

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

3

1

High-throughput

0.675

High

1419234

TRI54
Tripartite motif-containing protein 54

3

6

High-throughput

0.675

High

838794

MTREX
Exosome RNA helicase MTR4

3

19

High-throughput

0.675

High

155697

FCHO1
F-BAR domain only protein 1

3

2

High-throughput

0.667

High

244774

ZC3H1
Zinc finger C3H1 domain-containing protein

3

6

High-throughput

0.662

High

1146178

K1H1
Keratin, type I cuticular Ha1

3

5

High-throughput

0.654

High

1447235

TFP11
Tuftelin-interacting protein 11

3

2

High-throughput

0.654

High

970124

RS16
Small ribosomal subunit protein uS9

2

2

High-throughput

0.628

High

1240266

ZCHC8
Zinc finger CCHC domain-containing protein 8

2

4

High-throughput

0.628

High

1251448

GGYF2
GRB10-interacting GYF protein 2

2

5

High-throughput

0.628

High

1309714

WDR75
WD repeat-containing protein 75

2

19

High-throughput

0.628

High

1287221

PEG10
Retrotransposon-derived protein PEG10

3

0

High-throughput

0.626

High

64557

CC88B
Coiled-coil domain-containing protein 88B

2

2

High-throughput

0.606

High

300505

KRT34
Keratin, type I cuticular Ha4

2

5

High-throughput

0.606

High

386492

SPTA1
Spectrin alpha chain, erythrocytic 1

2

1

High-throughput

0.606

High

1111288

SNW1
SNW domain-containing protein 1

2

3

High-throughput

0.606

High

1112457

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

2

2

High-throughput

0.606

High

1186363

ZN792
Zinc finger protein 792

2

1

High-throughput

0.606

High

1253089

ZN620
Zinc finger protein 620

2

1

High-throughput

0.606

High

1277641

K1C27
Keratin, type I cytoskeletal 27

2

5

High-throughput

0.606

High

1330236

ZN655
Zinc finger protein 655

2

1

High-throughput

0.606

High

1353574

ZFP90
Zinc finger protein 90 homolog

2

1

High-throughput

0.606

High

1359132

PIHD2
PIH1 domain-containing protein 2

2

1

High-throughput

0.606

High

1360895

ACO11
Acyl-coenzyme A thioesterase 11

2

1

High-throughput

0.606

High

1361871

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

2

1

High-throughput

0.606

High

1367985

KRT35
Keratin, type I cuticular Ha5

2

5

High-throughput

0.606

High

1386890

DDT4L
DNA damage-inducible transcript 4-like protein

2

1

High-throughput

0.606

High

1411324

LZTS2
Leucine zipper putative tumor suppressor 2

2

2

High-throughput

0.606

High

1447229

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

1

High-throughput

0.606

High

1447240

WDR3
WD repeat-containing protein 3

2

20

High-throughput

0.601

High

1397922

DMRTB
Doublesex- and mab-3-related transcription factor B1

2

1

High-throughput

0.584

High

464293

FUMH
Fumarate hydratase, mitochondrial

2

0

High-throughput

0.580

High

478343

HXC4
Homeobox protein Hox-C4

2

0

High-throughput

0.580

High

1061891

TLE5
TLE family member 5

2

0

High-throughput

0.580

High

1347582

ZN420
Zinc finger protein 420

2

0

High-throughput

0.580

High

1361431

MYLIP
E3 ubiquitin-protein ligase MYLIP

2

0

High-throughput

0.580

High

1402054

TRIB3
Tribbles homolog 3

2

0

High-throughput

0.580

High

1415208

TRI62
E3 ubiquitin-protein ligase TRIM62

2

0

High-throughput

0.580

High

1447231

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

1095813

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

1

High-throughput

0.573

High

397012

ESR1
Estrogen receptor

2

12

High-throughput

0.571

High

1336635

PAPD5
Terminal nucleotidyltransferase 4B

2

3

High-throughput

0.571

High

1338519

DOCK8
Dedicator of cytokinesis protein 8

1

0

High-throughput

0.549

High

252171

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

4

High-throughput

0.536

High

447481

NPM
Nucleophosmin

1

1

High-throughput

0.536

High

1035464

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

1

High-throughput

0.536

High

1085715

TBL3
Transducin beta-like protein 3

1

15

High-throughput

0.536

High

1114383

CUL3
Cullin-3

1

1

High-throughput

0.536

High

1141420

WDR43
WD repeat-containing protein 43

1

20

High-throughput

0.536

High

1144741

PWP2
Periodic tryptophan protein 2 homolog

1

18

High-throughput

0.536

High

1162121

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

1

1

High-throughput

0.536

High

1352452

UTP15
U3 small nucleolar RNA-associated protein 15 homolog

1

13

High-throughput

0.536

High

1360494

PSPC1
Paraspeckle component 1

1

5

High-throughput

0.536

High

1381596

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

11

High-throughput

0.536

High

1429080

AICDA
Single-stranded DNA cytosine deaminase

1

6

Small-scale

0.536

High

1447232

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

1

High-throughput

0.536

High

1447233

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.536

High

1447236

ZO2
Tight junction protein 2

1

1

High-throughput

0.536

High

1447241

SRPK3
SRSF protein kinase 3

1

1

High-throughput

0.536

High

1063634

GOGA2
Golgin subfamily A member 2

1

1

High-throughput

0.523

High

1100646

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.518

High

1213021

SKT
Sickle tail protein homolog

1

0

High-throughput

0.518

High

2824

A0A0C3SFZ9
FCH and mu domain containing endocytic adaptor 1

1

2

High-throughput

0.515

High

1232596

Q6FHY5
MEOX2 protein

1

2

High-throughput

0.515

High

426965

FGF1
Fibroblast growth factor 1

1

0

High-throughput

0.513

High

542665

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

967572

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.513

High

1016247

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

1312774

RM41
Large ribosomal subunit protein mL41

1

0

High-throughput

0.513

High

1393922

SCLY
Selenocysteine lyase

1

0

High-throughput

0.513

High

1436262

NOL11
Nucleolar protein 11

1

0

High-throughput

0.513

High

1447246

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.513

High

655346

SFPQ
Splicing factor, proline- and glutamine-rich

1

5

High-throughput

0.508

High

1398993

ZN558
Zinc finger protein 558

1

1

High-throughput

0.508

High

1447249

LSM5
U6 snRNA-associated Sm-like protein LSm5

1

7

High-throughput

0.508

High

951864

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

High-throughput

0.501

High

573258

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.486

High

1403203

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

1

0

High-throughput

0.486

High

1447242

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.486

High

566312

K1C13
Keratin, type I cytoskeletal 13

1

6

High-throughput

0.481

High

894190

MEOX2
Homeobox protein MOX-2

1

2

High-throughput

0.481

High

974285

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

9

High-throughput

0.481

High

1116597

FHL3
Four and a half LIM domains protein 3

1

1

High-throughput

0.481

High

1204697

ZMAT1
Zinc finger matrin-type protein 1

1

1

High-throughput

0.481

High

1329121

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

2

High-throughput

0.481

High

1447230

SHLB2
Endophilin-B2

1

1

High-throughput

0.481

High

1447244

SHLB1
Endophilin-B1

1

2

High-throughput

0.481

High

129460

MEN1
Menin

1

4

High-throughput

0.479

High

173414

XPO1
Exportin-1

1

3

High-throughput

0.479

High

272480

OBSL1
Obscurin-like protein 1

1

3

High-throughput

0.479

High

316047

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

320074

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

346375

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

9

High-throughput

0.479

High

473112

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

9

High-throughput

0.479

High

589780

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

769263

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

872777

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

897986

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.479

High

914968

THOP1
Thimet oligopeptidase

1

4

High-throughput

0.479

High

971137

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

1089026

TP53B
TP53-binding protein 1

1

2

High-throughput

0.479

High

1255679

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1275697

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

Small-scale

0.479

High

1280526

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

High-throughput

0.479

High

1290750

ZCH18
Zinc finger CCCH domain-containing protein 18

1

5

High-throughput

0.479

High

1292414

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

1

Small-scale

0.479

High

1352771

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

1367361

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

1368637

KAT6A
Histone acetyltransferase KAT6A

1

5

High-throughput

0.479

High

1393725

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

1447234

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

5

High-throughput

0.479

High

1447237

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1447239

FZR1
Fizzy-related protein homolog

1

11

High-throughput

0.479

High

717

A0A087WWI0
Leucine-rich melanocyte differentiation-associated protein

1

6

High-throughput

0.470

High

49909

A1A4E9
Keratin 13

1

6

High-throughput

0.470

High

983713

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.460

High

1101243

NMI
N-myc-interactor

1

0

High-throughput

0.460

High

1198535

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.460

High

1280751

YTHD3
YTH domain-containing family protein 3

1

0

High-throughput

0.460

High

766881

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

1135820

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1271874

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1369397

DDX17
Probable ATP-dependent RNA helicase DDX17

1

0

Small-scale

0.458

High

1292878

STING
Stimulator of interferon genes protein

1

2

Small-scale

0.445

High

1286985

DAAM2
Disheveled-associated activator of morphogenesis 2

1

1

High-throughput

0.439

High

1431923

LRMDA
Leucine-rich melanocyte differentiation-associated protein

1

5

High-throughput

0.439

High

109161

G4U4J3
Terminal nucleotidyltransferase 4B

1

3

High-throughput

0.407

High

116291

H3BNT4
M-phase phosphoprotein 6

1

8

High-throughput

0.407

High

337238

LCA5L
Lebercilin-like protein

2

0

High-throughput

0.316

High

1206437

EFHC2
EF-hand domain-containing family member C2

2

0

High-throughput

0.316

High

1250323

ATL4
ADAMTS-like protein 4

2

0

High-throughput

0.316

High

1254165

SHSA6
Protein shisa-6

2

0

High-throughput

0.316

High

1256741

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.316

High

1392350

BORC6
BLOC-1-related complex subunit 6

2

0

High-throughput

0.316

High

1447248

TCAF1
TRPM8 channel-associated factor 1

2

0

High-throughput

0.313

High

270588

LRP4
Low-density lipoprotein receptor-related protein 4

1

0

High-throughput

0.279

Low

1352945

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.265

Low

1447251

LIPG
Endothelial lipase

1

0

High-throughput

0.265

Low

1314996

TEX11
Testis-expressed protein 11

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025