Protein: SOST
Sclerostin

Gene: SOST
Organism: Homo sapiens
Interactions: 40
UniProt ID: Q9BQB4

Gene Ontology (top 5):
GO:0001503 - ossification
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005794 - Golgi apparatus
GO:0008201 - heparin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

287602

LRP6
Low-density lipoprotein receptor-related protein 6

6

6

Small-scale

0.945

High

274911

LRP5
Low-density lipoprotein receptor-related protein 5

4

6

Small-scale

0.896

High

270584

LRP4
Low-density lipoprotein receptor-related protein 4

3

6

Small-scale

0.886

High

1022643

LRP2
Low-density lipoprotein receptor-related protein 2

2

6

High-throughput

0.811

High

1366664

SORL
Sortilin-related receptor

1

5

High-throughput

0.691

High

227652

SPOP
Speckle-type POZ protein

2

0

High-throughput

0.602

High

516049

CSH2
Chorionic somatomammotropin hormone 2

2

0

High-throughput

0.602

High

635372

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

2

0

High-throughput

0.602

High

1388708

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

0

High-throughput

0.602

High

1410446

PSMG3
Proteasome assembly chaperone 3

2

0

High-throughput

0.602

High

1410447

SRRT
Serrate RNA effector molecule homolog

2

0

High-throughput

0.602

High

282058

MPPB
Mitochondrial-processing peptidase subunit beta

2

1

High-throughput

0.574

High

1393310

SAHH3
Adenosylhomocysteinase 3

2

1

High-throughput

0.574

High

1395139

DCAF5
DDB1- and CUL4-associated factor 5

2

1

High-throughput

0.574

High

332437

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

1

High-throughput

0.536

High

337492

PSMG1
Proteasome assembly chaperone 1

1

0

High-throughput

0.513

High

1410452

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

0

High-throughput

0.513

High

1410453

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

0

High-throughput

0.513

High

171313

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

3

High-throughput

0.489

High

230100

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

1

High-throughput

0.489

High

1410448

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

1

High-throughput

0.489

High

1083721

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.445

High

1410451

TMM98
Transmembrane protein 98

1

0

High-throughput

0.426

High

295533

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

3

High-throughput

0.407

High

142612

IMA3
Importin subunit alpha-3

2

0

High-throughput

0.328

High

343032

HERC2
E3 ubiquitin-protein ligase HERC2

2

0

High-throughput

0.328

High

344776

AP2A1
AP-2 complex subunit alpha-1

2

0

High-throughput

0.328

High

657668

GCSP
Glycine dehydrogenase

2

0

High-throughput

0.328

High

1005949

GTF2I
General transcription factor II-I

2

0

High-throughput

0.328

High

1381307

PSMG2
Proteasome assembly chaperone 2

2

0

High-throughput

0.328

High

1396918

ANM6
Protein arginine N-methyltransferase 6

2

0

High-throughput

0.328

High

1410449

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

2

0

High-throughput

0.328

High

1410450

PKHF2
Pleckstrin homology domain-containing family F member 2

2

0

High-throughput

0.316

High

409605

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

0

High-throughput

0.279

Low

1339556

NEUA
N-acylneuraminate cytidylyltransferase

1

0

High-throughput

0.279

Low

1357819

NUDT8
Mitochondrial coenzyme A diphosphatase NUDT8

1

0

High-throughput

0.279

Low

1395390

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.279

Low

289369

CTAG2
Cancer/testis antigen 2

1

0

High-throughput

0.232

Low

1337519

DDHD1
Phospholipase DDHD1

1

0

High-throughput

0.232

Low

1339810

TRI58
E3 ubiquitin-protein ligase TRIM58

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025