Protein: KDM6B
Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B)

Gene: KDM6B
Organism: Homo sapiens
Interactions: 96
UniProt ID: O15054

Gene Ontology (top 5):
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0002437 - inflammatory response to antigenic stimulus
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006338 - chromatin remodeling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

176074

KDM7A
Lysine-specific demethylase 7A

2

3

Small-scale

0.789

High

176009

KDM6B
Lysine-specific demethylase 6B

1

13

Small-scale

0.618

High

176044

ANM2
Protein arginine N-methyltransferase 2

2

1

Small-scale

0.614

High

176082

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

13

Small-scale

0.584

High

176103

SCC4
MAU2 chromatid cohesion factor homolog

2

0

Small-scale

0.559

High

176057

SSRP1
FACT complex subunit SSRP1

1

13

High-throughput

0.536

High

176069

H2B2E
Histone H2B type 2-E

1

19

High-throughput

0.536

High

176021

H12
Histone H1.2

1

3

High-throughput

0.515

High

176052

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.508

High

176053

H31
Histone H3.1

1

14

Small-scale

0.501

High

176088

TSYL2
Testis-specific Y-encoded-like protein 2

1

1

Small-scale

0.501

High

176033

PROF2
Profilin-2

1

4

High-throughput

0.489

High

176017

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

176079

CBP
CREB-binding protein

1

15

Small-scale

0.481

High

176010

KLF4
Krueppel-like factor 4

1

13

Small-scale

0.479

High

176014

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

3

Small-scale

0.479

High

176016

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

176022

PRS6A
26S proteasome regulatory subunit 6A

1

7

Small-scale

0.479

High

176023

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

2

Small-scale

0.479

High

176024

FLNA
Filamin-A

1

4

Small-scale

0.479

High

176026

TBG1
Tubulin gamma-1 chain

1

2

Small-scale

0.479

High

176027

PSA1
Proteasome subunit alpha type-1

1

1

Small-scale

0.479

High

176031

DNJA1
DnaJ homolog subfamily A member 1

1

5

Small-scale

0.479

High

176034

RS27
Small ribosomal subunit protein eS27

1

2

Small-scale

0.479

High

176035

WASP
Actin nucleation-promoting factor WAS

1

8

Small-scale

0.479

High

176036

PRS6B
26S proteasome regulatory subunit 6B

1

2

Small-scale

0.479

High

176037

CRKL
Crk-like protein

1

9

Small-scale

0.479

High

176038

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

4

Small-scale

0.479

High

176039

SOX2
Transcription factor SOX-2

1

20

Small-scale

0.479

High

176042

STA5B
Signal transducer and activator of transcription 5B

1

1

Small-scale

0.479

High

176043

IMA5
Importin subunit alpha-5

1

2

Small-scale

0.479

High

176046

CH10
10 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

176047

DCAF7
DDB1- and CUL4-associated factor 7

1

12

Small-scale

0.479

High

176048

WDR5
WD repeat-containing protein 5

1

18

Small-scale

0.479

High

176049

PRS4
26S proteasome regulatory subunit 4

1

2

Small-scale

0.479

High

176051

PRS10
26S proteasome regulatory subunit 10B

1

2

Small-scale

0.479

High

176054

RAE1L
mRNA export factor RAE1

1

17

Small-scale

0.479

High

176055

SMAD3
Mothers against decapentaplegic homolog 3

1

6

Small-scale

0.479

High

176058

ACACA
Acetyl-CoA carboxylase 1

1

1

Small-scale

0.479

High

176059

CBX3
Chromobox protein homolog 3

1

2

Small-scale

0.479

High

176060

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

1

Small-scale

0.479

High

176061

SMAD4
Mothers against decapentaplegic homolog 4

1

7

Small-scale

0.479

High

176064

SYK
Lysine--tRNA ligase

1

3

Small-scale

0.479

High

176066

RBBP5
Retinoblastoma-binding protein 5

1

20

Small-scale

0.479

High

176067

SMAD2
Mothers against decapentaplegic homolog 2

1

6

Small-scale

0.479

High

176068

SMAD1
Mothers against decapentaplegic homolog 1

1

6

Small-scale

0.479

High

176073

NIPBL
Nipped-B-like protein

1

19

Small-scale

0.479

High

176075

RS27L
Ribosomal protein eS27-like

1

2

Small-scale

0.479

High

176076

SLN11
Schlafen family member 11

1

2

Small-scale

0.479

High

176078

GEMI5
Gem-associated protein 5

1

5

Small-scale

0.479

High

176080

TNPO1
Transportin-1

1

3

Small-scale

0.479

High

176081

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

13

Small-scale

0.479

High

176083

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

4

Small-scale

0.479

High

176084

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

14

Small-scale

0.479

High

176085

MEP50
Methylosome protein WDR77

1

20

Small-scale

0.479

High

176089

XPO5
Exportin-5

1

3

Small-scale

0.479

High

176091

TSAP1
tRNA selenocysteine 1-associated protein 1

1

4

Small-scale

0.479

High

176093

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

9

Small-scale

0.479

High

176094

DDX20
Probable ATP-dependent RNA helicase DDX20

1

8

Small-scale

0.479

High

176095

XPO7
Exportin-7

1

3

High-throughput

0.479

High

176099

UBQL1
Ubiquilin-1

1

2

Small-scale

0.479

High

176100

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

13

Small-scale

0.479

High

176101

NUDC
Nuclear migration protein nudC

1

1

Small-scale

0.479

High

176011

AKAP8
A-kinase anchor protein 8

1

0

Small-scale

0.458

High

176019

GSTP1
Glutathione S-transferase P

1

0

Small-scale

0.458

High

176025

PUR2
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

1

0

Small-scale

0.458

High

176029

EF1D
Elongation factor 1-delta

1

0

Small-scale

0.458

High

176045

GEMI4
Gem-associated protein 4

1

0

Small-scale

0.458

High

176050

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

Small-scale

0.458

High

176062

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.458

High

176071

PCID2
PCI domain-containing protein 2

1

0

Small-scale

0.458

High

176086

MCMBP
Mini-chromosome maintenance complex-binding protein

1

0

Small-scale

0.458

High

176098

DNPEP
Aspartyl aminopeptidase

1

0

Small-scale

0.458

High

176013

DNJA2
DnaJ homolog subfamily A member 2

1

5

Small-scale

0.437

High

176018

TPM3
Tropomyosin alpha-3 chain

1

3

Small-scale

0.437

High

176020

VAV
Proto-oncogene vav

1

8

Small-scale

0.437

High

176030

COR1A
Coronin-1A

1

18

Small-scale

0.437

High

176032

KINH
Kinesin-1 heavy chain

1

3

Small-scale

0.437

High

176041

GUAA
GMP synthase [glutamine-hydrolyzing]

1

1

Small-scale

0.437

High

176056

K1C17
Keratin, type I cytoskeletal 17

1

3

Small-scale

0.437

High

176065

PDIA6
Protein disulfide-isomerase A6

1

1

Small-scale

0.437

High

176070

P5CR3
Pyrroline-5-carboxylate reductase 3

1

2

Small-scale

0.437

High

176072

SLN13
Schlafen family member 13

1

2

Small-scale

0.437

High

176090

WDR6
tRNA

1

20

Small-scale

0.437

High

176092

ANFY1
Rabankyrin-5

1

7

Small-scale

0.437

High

176097

PNMA2
Paraneoplastic antigen Ma2

1

1

Small-scale

0.437

High

176012

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

0

Small-scale

0.249

Low

176015

TIPRL
TIP41-like protein

1

0

Small-scale

0.249

Low

176028

SYVC
Valine--tRNA ligase

1

0

Small-scale

0.249

Low

176040

RPIA
Ribose-5-phosphate isomerase

1

0

Small-scale

0.249

Low

176063

GANAB
Neutral alpha-glucosidase AB

1

0

Small-scale

0.249

Low

176077

FAD1
FAD synthase

1

0

Small-scale

0.249

Low

176087

THIC
Acetyl-CoA acetyltransferase, cytosolic

1

0

Small-scale

0.249

Low

176096

NAGK
N-acetyl-D-glucosamine kinase

1

0

Small-scale

0.249

Low

176102

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025