Protein: PLPL8
Calcium-independent phospholipase A2-gamma (EC 3.1.1.-) (EC 3.1.1.5) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (PNPLA-gamma) (Patatin-like phospholipase domain-containing protein 8) (iPLA2-2)

Gene: PLPL8, PNPLA8
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q9NP80

Gene Ontology (top 5):
GO:0001516 - prostaglandin biosynthetic process
GO:0004622 - phosphatidylcholine lysophospholipase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005777 - peroxisome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

279928

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

136140

PLK4
Serine/threonine-protein kinase PLK4

1

0

High-throughput

0.513

High

250846

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

856936

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.513

High

1389510

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

0

High-throughput

0.513

High

876187

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.493

High

282096

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

828973

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

856393

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

953120

ACTB
Actin, cytoplasmic 1

1

3

High-throughput

0.479

High

993340

ACTG
Actin, cytoplasmic 2

1

3

High-throughput

0.479

High

993445

ACTH
Actin, gamma-enteric smooth muscle

1

3

Small-scale

0.479

High

996545

ACTS
Actin, alpha skeletal muscle

1

3

High-throughput

0.479

High

1083765

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

122559

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

0

High-throughput

0.458

High

157882

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

351006

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

400024

CATA
Catalase

1

0

High-throughput

0.458

High

471263

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

519237

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

530407

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.458

High

786272

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.458

High

852042

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

882906

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

904136

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

907848

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.458

High

971120

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1015816

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.458

High

1048711

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1090554

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

1149635

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

1162570

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

1207151

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1367348

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1381735

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

1401630

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.458

High

1412596

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

1414094

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

1416553

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1418894

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1428810

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.458

High

1430478

RAB1B
Ras-related protein Rab-1B

1

0

High-throughput

0.458

High

1431970

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1435794

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1436096

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1446007

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

1446008

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1446009

NAT8B
N-acetyltransferase 8B

1

0

High-throughput

0.458

High

1446010

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.458

High

1255650

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1236332

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

1337966

ZNT7
Zinc transporter 7

1

0

High-throughput

0.426

High

274386

SIN3B
Paired amphipathic helix protein Sin3b

1

0

High-throughput

0.279

Low

280960

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.279

Low

682622

S100P
Protein S100-P

1

0

High-throughput

0.279

Low

1120351

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

High-throughput

0.279

Low

1368629

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.279

Low

106686

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

223348

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.249

Low

840800

RS27
Small ribosomal subunit protein eS27

1

0

High-throughput

0.249

Low

1107238

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

1292412

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.249

Low

58942

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025