Protein: HYPM
Huntingtin-interacting protein M (Histone H2A.P) (Huntingtin yeast partner M)

Gene: HYPM, H2AP
Organism: Homo sapiens
Interactions: 90
UniProt ID: O75409

Gene Ontology (top 5):
GO:0000786 - nucleosome
GO:0005634 - nucleus
GO:0030527 - structural constituent of chromatin
GO:0031507 - heterochromatin formation
GO:0046982 - protein heterodimerization activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

280898

MYOG
Myogenin

3

0

High-throughput

0.646

High

280902

HD
Huntingtin

3

0

Small-scale

0.639

High

280919

SIX1
Homeobox protein SIX1

3

0

High-throughput

0.636

High

280955

CENPH
Centromere protein H

3

0

High-throughput

0.636

High

280974

NEMO
NF-kappa-B essential modulator

2

0

High-throughput

0.585

High

191893

MAGB4
Melanoma-associated antigen B4

2

0

High-throughput

0.580

High

280947

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

280901

MTOR
Serine/threonine-protein kinase mTOR

1

1

High-throughput

0.536

High

280914

ATM
Serine-protein kinase ATM

1

1

High-throughput

0.536

High

280910

ATX1
Ataxin-1

1

0

High-throughput

0.518

High

280891

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.513

High

280896

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

High-throughput

0.513

High

280907

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.513

High

280913

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

280915

TARB1
tRNA

1

0

High-throughput

0.513

High

280917

CND1
Condensin complex subunit 1

1

0

High-throughput

0.513

High

280920

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

280922

TKFC
Triokinase/FMN cyclase

1

0

High-throughput

0.513

High

280931

UB2Q1
Ubiquitin-conjugating enzyme E2 Q1

1

0

High-throughput

0.513

High

280932

MET16
RNA N(6)-adenosine-methyltransferase METTL16

1

0

High-throughput

0.513

High

280935

DLP1
All trans-polyprenyl-diphosphate synthase PDSS2

1

0

High-throughput

0.513

High

280941

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

High-throughput

0.513

High

280942

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

0

High-throughput

0.513

High

280949

XPO6
Exportin-6

1

0

High-throughput

0.513

High

280950

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

0

High-throughput

0.513

High

280951

CSN8
COP9 signalosome complex subunit 8

1

0

High-throughput

0.513

High

280952

CND3
Condensin complex subunit 3

1

0

High-throughput

0.513

High

280956

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.513

High

280958

RDH14
Retinol dehydrogenase 14

1

0

High-throughput

0.513

High

280962

LANC2
LanC-like protein 2

1

0

High-throughput

0.513

High

280967

FEM1B
Protein fem-1 homolog B

1

0

High-throughput

0.513

High

280969

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

0

High-throughput

0.513

High

280970

PLAP
Phospholipase A-2-activating protein

1

0

High-throughput

0.513

High

280972

MTCH2
Mitochondrial carrier homolog 2

1

0

High-throughput

0.513

High

280894

APOE
Apolipoprotein E

1

0

High-throughput

0.493

High

280909

ATX3
Ataxin-3

1

0

High-throughput

0.493

High

270865

CLAP2
CLIP-associating protein 2

1

1

High-throughput

0.489

High

280930

CLAP1
CLIP-associating protein 1

1

2

High-throughput

0.489

High

280954

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

1

High-throughput

0.489

High

280965

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

1

High-throughput

0.489

High

280953

CEP44
Centrosomal protein of 44 kDa

3

0

High-throughput

0.352

High

280964

SEP10
Septin-10

2

0

High-throughput

0.320

High

280936

ZDH17
Palmitoyltransferase ZDHHC17

1

0

High-throughput

0.282

High

183113

GNPAT
Dihydroxyacetone phosphate acyltransferase

1

0

High-throughput

0.279

Low

269819

IGSF3
Immunoglobulin superfamily member 3

1

0

High-throughput

0.279

Low

280889

AP1G2
AP-1 complex subunit gamma-like 2

1

0

High-throughput

0.279

Low

280892

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.279

Low

280893

MPZL1
Myelin protein zero-like protein 1

1

0

High-throughput

0.279

Low

280899

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.279

Low

280903

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

280904

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

1

0

High-throughput

0.279

Low

280906

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.279

Low

280908

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

0

High-throughput

0.279

Low

280911

RAP1A
Ras-related protein Rap-1A

1

0

High-throughput

0.279

Low

280912

CANB1
Calcineurin subunit B type 1

1

0

High-throughput

0.279

Low

280916

CND2
Condensin complex subunit 2

1

0

High-throughput

0.279

Low

280918

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

0

High-throughput

0.279

Low

280921

PGPS1
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

280924

MARC1
Mitochondrial amidoxime-reducing component 1

1

0

High-throughput

0.279

Low

280925

STEA3
Metalloreductase STEAP3

1

0

High-throughput

0.279

Low

280926

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

0

High-throughput

0.279

Low

280927

ZFY26
Zinc finger FYVE domain-containing protein 26

1

0

High-throughput

0.279

Low

280928

NCEH1
Neutral cholesterol ester hydrolase 1

1

0

High-throughput

0.279

Low

280929

MAVS
Mitochondrial antiviral-signaling protein

1

0

High-throughput

0.279

Low

280933

DGKH
Diacylglycerol kinase eta

1

0

High-throughput

0.279

Low

280934

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.279

Low

280937

GHDC
GH3 domain-containing protein

1

0

High-throughput

0.279

Low

280938

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.279

Low

280939

PAR16
Protein mono-ADP-ribosyltransferase PARP16

1

0

High-throughput

0.279

Low

280940

GDPD1
Lysophospholipase D GDPD1

1

0

High-throughput

0.279

Low

280943

SYMPK
Symplekin

1

0

High-throughput

0.279

Low

280944

OTUL
Ubiquitin thioesterase otulin

1

0

High-throughput

0.279

Low

280945

LRC45
Leucine-rich repeat-containing protein 45

1

0

High-throughput

0.279

Low

280946

MITOK
Mitochondrial potassium channel

1

0

High-throughput

0.279

Low

280948

SPTCS
Spatacsin

1

0

High-throughput

0.279

Low

280957

AGRL3
Adhesion G protein-coupled receptor L3

1

0

High-throughput

0.279

Low

280959

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

1

0

High-throughput

0.279

Low

280960

PLPL8
Calcium-independent phospholipase A2-gamma

1

0

High-throughput

0.279

Low

280961

F1142
Protein FAM114A2

1

0

High-throughput

0.279

Low

280963

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

0

High-throughput

0.279

Low

280966

CS025
UPF0449 protein C19orf25

1

0

High-throughput

0.279

Low

280968

PSME2
Proteasome activator complex subunit 2

1

0

High-throughput

0.279

Low

280973

5MP1
eIF5-mimic protein 1

1

0

High-throughput

0.279

Low

280890

WFS1
Wolframin

1

0

High-throughput

0.268

Low

280895

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

280897

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.268

Low

280900

GRN
Progranulin

1

0

High-throughput

0.268

Low

280905

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.268

Low

280923

GLE1
mRNA export factor GLE1

1

0

High-throughput

0.268

Low

280971

SHLB1
Endophilin-B1

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025