Protein: CARD9
Caspase recruitment domain-containing protein 9 (hCARD9)

Gene: CARD9
Organism: Homo sapiens
Interactions: 194
UniProt ID: Q9H257

Gene Ontology (top 5):
GO:0001819 - positive regulation of cytokine production
GO:0002446 - neutrophil mediated immunity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

353901

BCL10
B-cell lymphoma/leukemia 10

6

6

Small-scale

0.945

High

1431499

CARD9
Caspase recruitment domain-containing protein 9

5

17

Small-scale

0.928

High

1416367

CAR10
Caspase recruitment domain-containing protein 10

3

9

High-throughput

0.836

High

1431505

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

2

2

Small-scale

0.754

High

1431503

UNKL
Putative E3 ubiquitin-protein ligase UNKL

2

0

High-throughput

0.742

High

1415207

TRI62
E3 ubiquitin-protein ligase TRIM62

4

8

Small-scale

0.708

High

1185324

F161A
Protein FAM161A

4

1

High-throughput

0.698

High

1239740

PPR18
Phostensin

4

7

High-throughput

0.698

High

1431516

PAK5
Serine/threonine-protein kinase PAK 5

4

20

High-throughput

0.698

High

1431532

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

3

16

Small-scale

0.680

High

1218957

TASO2
Protein TASOR 2

3

8

High-throughput

0.675

High

1330228

ZN655
Zinc finger protein 655

3

5

High-throughput

0.675

High

1431517

TFP11
Tuftelin-interacting protein 11

3

1

High-throughput

0.675

High

1431522

DS13B
Dual specificity protein phosphatase 13B

3

7

High-throughput

0.675

High

1431531

AMOL2
Angiomotin-like protein 2

3

17

High-throughput

0.675

High

1402901

CK5P2
CDK5 regulatory subunit-associated protein 2

3

19

High-throughput

0.667

High

940465

TCL1A
T-cell leukemia/lymphoma protein 1A

3

0

High-throughput

0.646

High

1277128

ZN572
Zinc finger protein 572

4

4

High-throughput

0.637

High

894156

MEOX2
Homeobox protein MOX-2

2

2

High-throughput

0.633

High

1431525

VPS28
Vacuolar protein sorting-associated protein 28 homolog

2

1

High-throughput

0.629

High

1326260

SESQ1
Sesquipedalian-1

2

13

High-throughput

0.628

High

475686

K1C19
Keratin, type I cytoskeletal 19

2

10

High-throughput

0.628

High

783412

TRI23
E3 ubiquitin-protein ligase TRIM23

2

1

High-throughput

0.628

High

1350719

CCHCR
Coiled-coil alpha-helical rod protein 1

2

19

High-throughput

0.628

High

1392127

CDA7L
Cell division cycle-associated 7-like protein

2

0

High-throughput

0.618

High

214461

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

5

Small-scale

0.618

High

585101

ZN250
Zinc finger protein 250

3

2

High-throughput

0.616

High

935627

MFAP1
Microfibrillar-associated protein 1

3

1

High-throughput

0.616

High

1180498

C19L2
CWF19-like protein 2

3

1

High-throughput

0.616

High

1331101

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

3

2

High-throughput

0.616

High

1385260

LENG1
Leukocyte receptor cluster member 1

3

1

High-throughput

0.616

High

1402947

ZN587
Zinc finger protein 587

3

6

High-throughput

0.616

High

1226265

CP135
Centrosomal protein of 135 kDa

2

17

High-throughput

0.611

High

64553

CC88B
Coiled-coil domain-containing protein 88B

2

17

High-throughput

0.606

High

288513

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

16

High-throughput

0.606

High

341856

K2C75
Keratin, type II cytoskeletal 75

2

3

High-throughput

0.606

High

353745

DRC4
Dynein regulatory complex subunit 4

2

1

High-throughput

0.606

High

463221

YES
Tyrosine-protein kinase Yes

2

13

High-throughput

0.606

High

476393

K1C16
Keratin, type I cytoskeletal 16

2

10

High-throughput

0.606

High

478726

HXB5
Homeobox protein Hox-B5

2

3

High-throughput

0.606

High

618110

K1C15
Keratin, type I cytoskeletal 15

2

8

High-throughput

0.606

High

681719

PSA4
Proteasome subunit alpha type-4

2

3

High-throughput

0.606

High

807578

IF4A3
Eukaryotic initiation factor 4A-III

2

2

High-throughput

0.606

High

933893

GEM
GTP-binding protein GEM

2

2

High-throughput

0.606

High

1051420

ZBT16
Zinc finger and BTB domain-containing protein 16

2

6

High-throughput

0.606

High

1121334

TRI14
Tripartite motif-containing protein 14

2

9

High-throughput

0.606

High

1158535

CDC37
Hsp90 co-chaperone Cdc37

2

1

High-throughput

0.606

High

1193184

USH1G
pre-mRNA splicing regulator USH1G

2

8

High-throughput

0.606

High

1225070

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

10

High-throughput

0.606

High

1235814

KRA57
Keratin-associated protein 5-7

2

6

High-throughput

0.606

High

1314944

CCD13
Coiled-coil domain-containing protein 13

2

18

High-throughput

0.606

High

1317110

TENS4
Tensin-4

2

2

High-throughput

0.606

High

1327459

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

2

1

High-throughput

0.606

High

1347384

LMO3
LIM domain only protein 3

2

4

High-throughput

0.606

High

1348496

LNX1
E3 ubiquitin-protein ligase LNX

2

3

High-throughput

0.606

High

1408325

PKP2
Plakophilin-2

2

9

High-throughput

0.606

High

1431502

MT21D
Protein N-lysine methyltransferase METTL21D

2

2

High-throughput

0.606

High

1431507

CABP2
Calcium-binding protein 2

2

3

High-throughput

0.606

High

1431510

DISC1
Disrupted in schizophrenia 1 protein

2

5

High-throughput

0.606

High

1431514

STMN3
Stathmin-3

2

1

High-throughput

0.606

High

1431520

ZRAN1
Ubiquitin thioesterase ZRANB1

2

9

High-throughput

0.606

High

1431524

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

17

High-throughput

0.606

High

1431526

IKZF3
Zinc finger protein Aiolos

2

5

High-throughput

0.606

High

1431529

LZTS1
Leucine zipper putative tumor suppressor 1

2

17

High-throughput

0.606

High

1431530

ADIP
Afadin- and alpha-actinin-binding protein

2

0

High-throughput

0.606

High

506810

GSTT2
Glutathione S-transferase theta-2B

2

0

High-throughput

0.602

High

1431521

ENOPH
Enolase-phosphatase E1

2

0

High-throughput

0.602

High

505767

ZN688
Zinc finger protein 688

3

10

High-throughput

0.597

High

998015

CSK21
Casein kinase II subunit alpha

1

17

Small-scale

0.597

High

1390404

EDC3
Enhancer of mRNA-decapping protein 3

2

0

High-throughput

0.585

High

155353

CDKA1
Cyclin-dependent kinase 2-associated protein 1

2

0

High-throughput

0.580

High

269375

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

1336398

SLAI1
SLAIN motif-containing protein 1

2

0

High-throughput

0.580

High

1390160

MCRS1
Microspherule protein 1

2

0

High-throughput

0.580

High

1392902

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1431509

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

1417017

CAR11
Caspase recruitment domain-containing protein 11

1

8

High-throughput

0.575

High

1431527

ASC
Apoptosis-associated speck-like protein containing a CARD

1

1

Small-scale

0.575

High

1061871

TLE5
TLE family member 5

2

6

High-throughput

0.573

High

159263

ABLM1
Actin-binding LIM protein 1

1

6

High-throughput

0.573

High

286725

STX11
Syntaxin-11

1

5

High-throughput

0.573

High

682102

RBTN1
Rhombotin-1

1

4

High-throughput

0.573

High

991424

SUMO1
Small ubiquitin-related modifier 1

1

1

High-throughput

0.573

High

1117922

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

1

15

High-throughput

0.573

High

1146157

K1H1
Keratin, type I cuticular Ha1

1

17

High-throughput

0.573

High

1230257

K1C40
Keratin, type I cytoskeletal 40

1

17

High-throughput

0.573

High

1238119

HMBX1
Homeobox-containing protein 1

1

2

High-throughput

0.573

High

1271406

KCTD9
BTB/POZ domain-containing protein KCTD9

1

12

High-throughput

0.573

High

1411292

LZTS2
Leucine zipper putative tumor suppressor 2

1

19

High-throughput

0.573

High

1419217

TRI54
Tripartite motif-containing protein 54

1

19

High-throughput

0.573

High

1431519

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.573

High

159853

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

7

High-throughput

0.560

High

1242495

NFRKB
Nuclear factor related to kappa-B-binding protein

2

1

High-throughput

0.558

High

822861

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.554

High

600072

ZNF19
Zinc finger protein 19

2

4

High-throughput

0.553

High

600123

ZNF20
Zinc finger protein 20

2

9

High-throughput

0.553

High

946061

ZN121
Zinc finger protein 121

2

7

High-throughput

0.553

High

1185836

ZN829
Zinc finger protein 829

2

7

High-throughput

0.553

High

1206428

EFHC2
EF-hand domain-containing family member C2

2

1

High-throughput

0.553

High

1239206

ZN774
Zinc finger protein 774

2

6

High-throughput

0.553

High

1253085

ZN620
Zinc finger protein 620

2

5

High-throughput

0.553

High

1398643

F161B
Protein FAM161B

2

1

High-throughput

0.553

High

1406153

PRP18
Pre-mRNA-splicing factor 18

2

1

High-throughput

0.553

High

1414760

ZN426
Zinc finger protein 426

2

7

High-throughput

0.553

High

1415227

KIFC3
Kinesin-like protein KIFC3

2

2

High-throughput

0.553

High

1416175

SCNM1
Sodium channel modifier 1

2

1

High-throughput

0.553

High

1431506

CBX8
Chromobox protein homolog 8

2

1

High-throughput

0.553

High

1431511

FX4L1
Forkhead box protein D4-like 1

2

4

High-throughput

0.553

High

1431513

RBAK
RB-associated KRAB zinc finger protein

2

2

High-throughput

0.553

High

252163

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.549

High

1279977

NECA2
N-terminal EF-hand calcium-binding protein 2

1

0

High-throughput

0.549

High

1315784

CE57L
Centrosomal protein CEP57L1

1

0

High-throughput

0.549

High

1325598

ZCHC7
Zinc finger CCHC domain-containing protein 7

1

0

High-throughput

0.549

High

1340348

CEP70
Centrosomal protein of 70 kDa

1

0

High-throughput

0.549

High

1405613

TSNAX
Translin-associated protein X

1

0

High-throughput

0.549

High

1431500

GO45
Golgin-45

1

0

High-throughput

0.549

High

181172

AXIN1
Axin-1

1

6

High-throughput

0.541

High

50140

BICL2
BICD family-like cargo adapter 2

1

20

High-throughput

0.536

High

472403

FGF4
Fibroblast growth factor 4

1

2

High-throughput

0.536

High

725548

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

5

High-throughput

0.536

High

969436

RS8
Small ribosomal subunit protein eS8

1

1

High-throughput

0.536

High

1071188

ARL16
ADP-ribosylation factor-like protein 16

1

4

High-throughput

0.536

High

1181543

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

2

High-throughput

0.536

High

1278804

HDGR2
Hepatoma-derived growth factor-related protein 2

1

1

High-throughput

0.536

High

1357697

SNX33
Sorting nexin-33

1

2

High-throughput

0.536

High

1408533

AKAP9
A-kinase anchor protein 9

1

17

High-throughput

0.536

High

823913

PBX2
Pre-B-cell leukemia transcription factor 2

1

2

High-throughput

0.523

High

1120965

TRI29
Tripartite motif-containing protein 29

1

12

High-throughput

0.523

High

1311472

TRI42
Tripartite motif-containing protein 42

1

20

High-throughput

0.523

High

1312499

PHC2
Polyhomeotic-like protein 2

1

1

High-throughput

0.523

High

1347729

ZN417
Zinc finger protein 417

1

7

High-throughput

0.523

High

1400222

PNMA5
Paraneoplastic antigen-like protein 5

1

6

High-throughput

0.523

High

1431501

F124B
Protein FAM124B

1

1

High-throughput

0.523

High

1154589

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.518

High

1369770

RAD50
DNA repair protein RAD50

1

20

Small-scale

0.515

High

69862

A8K932
Kinesin-like protein

1

9

High-throughput

0.515

High

950128

KR105
Keratin-associated protein 10-5

1

6

High-throughput

0.515

High

1200651

Q548N1
Vacuolar protein sorting-associated protein 28 homolog

1

1

High-throughput

0.515

High

1369699

KLK6
Kallikrein-6

1

1

High-throughput

0.515

High

1395460

MY15B
Unconventional myosin-XVB

1

16

High-throughput

0.515

High

1051858

EF1A2
Elongation factor 1-alpha 2

1

0

High-throughput

0.513

High

1211851

THEM4
Acyl-coenzyme A thioesterase THEM4

1

0

High-throughput

0.513

High

1218355

OTUD1
OTU domain-containing protein 1

1

2

Small-scale

0.512

High

1234675

IQCE
IQ domain-containing protein E

1

18

High-throughput

0.494

High

1386876

DDT4L
DNA damage-inducible transcript 4-like protein

1

0

High-throughput

0.493

High

949778

KR101
Keratin-associated protein 10-1

1

6

High-throughput

0.481

High

949997

KR103
Keratin-associated protein 10-3

1

6

High-throughput

0.481

High

993741

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.481

High

1361155

PIBF1
Progesterone-induced-blocking factor 1

1

3

High-throughput

0.481

High

1431504

KIF9
Kinesin-like protein KIF9

1

9

High-throughput

0.481

High

138313

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

4

High-throughput

0.479

High

730230

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.479

High

70474

CRTP1
Cysteine-rich tail protein 1

1

1

High-throughput

0.470

High

1194584

Q4G0R1
PIBF1 protein

1

3

High-throughput

0.470

High

1232570

Q6FHY5
MEOX2 protein

1

2

High-throughput

0.470

High

1270726

Q7KZS0
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.470

High

1289891

Q86V38
Atrophin 1

1

1

High-throughput

0.470

High

1431515

ZN224
Zinc finger protein 224

1

2

High-throughput

0.470

High

562814

CY24A
Cytochrome b-245 light chain

1

0

Small-scale

0.458

High

912640

GDIR2
Rho GDP-dissociation inhibitor 2

1

0

Small-scale

0.458

High

1365939

RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

1

0

Small-scale

0.458

High

3360

A0A0S2Z4M1
Axin-1

1

6

High-throughput

0.457

High

595106

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

5

High-throughput

0.445

High

1132434

CASP8
Caspase-8

1

2

Small-scale

0.445

High

1228520

TENS3
Tensin-3

1

5

High-throughput

0.445

High

1431518

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

9

Small-scale

0.445

High

1395345

CC136
Coiled-coil domain-containing protein 136

1

15

High-throughput

0.439

High

627164

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.426

High

1216399

FAXC
Failed axon connections homolog

1

0

High-throughput

0.426

High

3566

A0A0S2Z5X4
Zinc finger protein 688 isoform 4

1

6

High-throughput

0.417

High

1314607

IHO1
Interactor of HORMAD1 protein 1

3

0

High-throughput

0.352

High

1256466

K0408
Uncharacterized protein KIAA0408

2

0

High-throughput

0.317

High

211211

CMIP4
Ciliary microtubule inner protein 4

2

0

High-throughput

0.316

High

1187684

T10IP
Testis-specific protein 10-interacting protein

2

0

High-throughput

0.316

High

1198851

ZC21C
Zinc finger C2HC domain-containing protein 1C

2

0

High-throughput

0.316

High

1254162

SHSA6
Protein shisa-6

2

0

High-throughput

0.316

High

1287058

K1328
Protein hinderin

2

0

High-throughput

0.316

High

1295107

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1315051

ZZZ3
ZZ-type zinc finger-containing protein 3

2

0

High-throughput

0.316

High

1315744

SAXO1
Stabilizer of axonemal microtubules 1

2

0

High-throughput

0.316

High

1380964

LMBL2
Lethal(3)malignant brain tumor-like protein 2

2

0

High-throughput

0.316

High

1420607

IN80B
INO80 complex subunit B

2

0

High-throughput

0.316

High

1431523

ZMYM5
Zinc finger MYM-type protein 5

2

0

High-throughput

0.316

High

1135993

RTP5
Receptor-transporting protein 5

1

0

High-throughput

0.299

High

1200591

CTSRT
Cation channel sperm-associated targeting subunit tau

1

0

High-throughput

0.299

High

1241240

CA094
Uncharacterized protein C1orf94

1

0

High-throughput

0.299

High

1431528

FA50B
Protein FAM50B

1

0

High-throughput

0.299

High

1126364

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.279

Low

1431508

NOP10
H/ACA ribonucleoprotein complex subunit 3

1

0

High-throughput

0.279

Low

1392989

CC120
Coiled-coil domain-containing protein 120

1

0

High-throughput

0.268

Low

1431512

SPAT6
Spermatogenesis-associated protein 6

1

0

High-throughput

0.268

Low

1351341

BPIB1
BPI fold-containing family B member 1

1

0

High-throughput

0.232

Low

1358572

POF1B
Protein POF1B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025