Protein: PLS1
Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (Mg(2+)-dependent nuclease) (EC 3.1.-.-) (MmTRA1b)

Gene: PLS1, PLSCR1
Organism: Homo sapiens
Interactions: 174
UniProt ID: O15162

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001618 - virus receptor activity
GO:0003677 - DNA binding
GO:0004518 - nuclease activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

170115

ESR2
Estrogen receptor beta

3

3

High-throughput

0.690

High

170011

GLRX3
Glutaredoxin-3

2

1

High-throughput

0.646

High

170074

DAZP2
DAZ-associated protein 2

2

1

High-throughput

0.646

High

170146

REEP1
Receptor expression-enhancing protein 1

2

2

High-throughput

0.628

High

170063

EWS
RNA-binding protein EWS

2

0

High-throughput

0.618

High

170022

HRG
Histidine-rich glycoprotein

2

2

High-throughput

0.614

High

170024

A4
Amyloid-beta precursor protein

2

2

High-throughput

0.611

High

170085

TM128
Transmembrane protein 128

2

1

High-throughput

0.611

High

170158

GDE1
Glycerophosphodiester phosphodiesterase 1

2

1

High-throughput

0.611

High

170051

ANX11
Annexin A11

2

2

High-throughput

0.608

High

170152

PLS4
Phospholipid scramblase 4

2

4

High-throughput

0.608

High

170127

CLCC1
Chloride channel CLIC-like protein 1

2

0

High-throughput

0.602

High

170048

RGS3
Regulator of G-protein signaling 3

2

0

High-throughput

0.601

High

170133

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.601

High

170040

SHC1
SHC-transforming protein 1

2

0

Small-scale

0.598

High

170078

CRY1
Cryptochrome-1

2

0

High-throughput

0.587

High

170071

MVP
Major vault protein

2

1

High-throughput

0.584

High

170060

S35A2
UDP-galactose translocator

2

0

High-throughput

0.582

High

170062

REEP5
Receptor expression-enhancing protein 5

2

2

High-throughput

0.574

High

60534

VP37C
Vacuolar protein sorting-associated protein 37C

1

2

High-throughput

0.573

High

170009

STK16
Serine/threonine-protein kinase 16

1

1

High-throughput

0.573

High

170056

KR109
Keratin-associated protein 10-9

1

11

High-throughput

0.573

High

170075

P2RY6
P2Y purinoceptor 6

1

3

High-throughput

0.573

High

170092

LEG9C
Galectin-9C

1

7

High-throughput

0.573

High

170100

TRI42
Tripartite motif-containing protein 42

1

8

High-throughput

0.573

High

170107

CTSR1
Cation channel sperm-associated protein 1

1

1

High-throughput

0.573

High

170108

ZN417
Zinc finger protein 417

1

1

High-throughput

0.573

High

170118

SMRC1
SWI/SNF complex subunit SMARCC1

1

4

High-throughput

0.573

High

170128

ZN587
Zinc finger protein 587

1

1

High-throughput

0.573

High

170134

KRA92
Keratin-associated protein 9-2

1

10

High-throughput

0.573

High

170135

KR411
Keratin-associated protein 4-11

1

11

High-throughput

0.573

High

170136

KRA42
Keratin-associated protein 4-2

1

11

High-throughput

0.573

High

170143

DEFI6
Differentially expressed in FDCP 6 homolog

1

1

High-throughput

0.573

High

170150

DMRT3
Doublesex- and mab-3-related transcription factor 3

1

2

High-throughput

0.573

High

170157

PRR13
Proline-rich protein 13

1

2

High-throughput

0.573

High

170068

ILF3
Interleukin enhancer-binding factor 3

2

0

High-throughput

0.559

High

170080

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.558

High

170097

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.558

High

170112

NEUR4
Sialidase-4

1

0

High-throughput

0.558

High

170116

TFG
Protein TFG

1

0

High-throughput

0.558

High

170006

FRS3
Fibroblast growth factor receptor substrate 3

1

0

High-throughput

0.549

High

170070

PKD2
Polycystin-2

1

0

High-throughput

0.549

High

170093

KRA56
Keratin-associated protein 5-6

1

0

High-throughput

0.549

High

170114

DOCK2
Dedicator of cytokinesis protein 2

1

0

High-throughput

0.549

High

170162

CATZ
Cathepsin Z

1

0

High-throughput

0.549

High

170014

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

5

High-throughput

0.541

High

170032

HXB6
Homeobox protein Hox-B6

1

1

High-throughput

0.541

High

170037

CNTFR
Ciliary neurotrophic factor receptor subunit alpha

1

3

High-throughput

0.541

High

170042

HXA9
Homeobox protein Hox-A9

1

5

High-throughput

0.541

High

170044

CRK
Adapter molecule crk

1

1

High-throughput

0.541

High

170047

HXA1
Homeobox protein Hox-A1

1

5

High-throughput

0.541

High

170049

MCSP
Sperm mitochondrial-associated cysteine-rich protein

1

1

High-throughput

0.541

High

170053

ATN1
Atrophin-1

1

2

High-throughput

0.541

High

170059

PITX1
Pituitary homeobox 1

1

3

High-throughput

0.541

High

170065

ZBT16
Zinc finger and BTB domain-containing protein 16

1

1

High-throughput

0.541

High

170067

KIF1A
Kinesin-like protein KIF1A

1

1

High-throughput

0.541

High

170088

INT11
Integrator complex subunit 11

1

1

High-throughput

0.541

High

170095

DLK2
Protein delta homolog 2

1

2

High-throughput

0.541

High

170096

ATL4
ADAMTS-like protein 4

1

3

High-throughput

0.541

High

170122

ZN764
Zinc finger protein 764

1

1

High-throughput

0.541

High

170126

MED15
Mediator of RNA polymerase II transcription subunit 15

1

2

High-throughput

0.541

High

170130

KR412
Keratin-associated protein 4-12

1

12

High-throughput

0.541

High

170131

RAMAC
RNA guanine-N7 methyltransferase activating subunit

1

1

High-throughput

0.541

High

170147

NET4
Netrin-4

1

3

High-throughput

0.541

High

170149

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

1

2

High-throughput

0.541

High

170153

PLS3
Phospholipid scramblase 3

1

4

High-throughput

0.541

High

170159

ZN581
Zinc finger protein 581

1

1

High-throughput

0.541

High

170160

RERE
Arginine-glutamic acid dipeptide repeats protein

1

2

High-throughput

0.541

High

170166

RASD1
Dexamethasone-induced Ras-related protein 1

1

1

High-throughput

0.541

High

156748

FFAR1
Free fatty acid receptor 1

1

5

High-throughput

0.536

High

157790

T4S5
Transmembrane 4 L6 family member 5

1

1

High-throughput

0.536

High

170026

CD63
CD63 antigen

1

3

High-throughput

0.536

High

170028

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

1

High-throughput

0.536

High

170036

NK1R
Substance-P receptor

1

1

High-throughput

0.536

High

170043

CNR2
Cannabinoid receptor 2

1

3

Small-scale

0.536

High

170069

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

3

High-throughput

0.536

High

170123

REEP6
Receptor expression-enhancing protein 6

1

2

High-throughput

0.536

High

170020

SLPI
Antileukoproteinase

1

0

Small-scale

0.529

High

170089

LCE4A
Late cornified envelope protein 4A

1

1

High-throughput

0.523

High

170090

LCE2D
Late cornified envelope protein 2D

1

2

High-throughput

0.523

High

170141

CHRD
Chordin

1

7

High-throughput

0.523

High

170007

SPY2
Protein sprouty homolog 2

1

0

High-throughput

0.518

High

170008

GRIN2
G protein-regulated inducer of neurite outgrowth 2

1

0

High-throughput

0.518

High

170012

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.518

High

170023

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

0

High-throughput

0.518

High

170029

ADT3
ADP/ATP translocase 3

1

0

High-throughput

0.518

High

170050

VASP
Vasodilator-stimulated phosphoprotein

1

0

High-throughput

0.518

High

170061

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.518

High

170064

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

0

High-throughput

0.518

High

170072

LASP1
LIM and SH3 domain protein 1

1

0

High-throughput

0.518

High

170073

ZN638
Zinc finger protein 638

1

0

High-throughput

0.518

High

170077

SF01
Splicing factor 1

1

0

High-throughput

0.518

High

170098

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.518

High

170111

PHLA1
Pleckstrin homology-like domain family A member 1

1

0

High-throughput

0.518

High

170132

NOC4L
Nucleolar complex protein 4 homolog

1

0

High-throughput

0.518

High

170137

YIPF3
Protein YIPF3

1

0

High-throughput

0.518

High

170138

IQCN
IQ domain-containing protein N

1

0

High-throughput

0.518

High

170145

VISTA
V-type immunoglobulin domain-containing suppressor of T-cell activation

1

0

High-throughput

0.518

High

170151

NPDC1
Neural proliferation differentiation and control protein 1

1

0

High-throughput

0.518

High

170154

DEPP1
Protein DEPP1

1

0

High-throughput

0.518

High

170155

NECP2
Adaptin ear-binding coat-associated protein 2

1

0

High-throughput

0.518

High

170161

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

0

High-throughput

0.518

High

170164

IP6K2
Inositol hexakisphosphate kinase 2

1

0

High-throughput

0.518

High

170165

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

0

High-throughput

0.518

High

66755

A8KA13
B-cell CLL/lymphoma 6, member B

1

2

High-throughput

0.515

High

170057

KR10B
Keratin-associated protein 10-11

1

11

High-throughput

0.515

High

170004

COPT2
Protein SLC31A2

1

0

High-throughput

0.513

High

170010

PRAF3
PRA1 family protein 3

1

0

High-throughput

0.513

High

170046

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

High-throughput

0.513

High

170054

IOD3
Thyroxine 5-deiodinase

1

0

High-throughput

0.513

High

170091

STUM
Protein stum homolog

1

0

High-throughput

0.513

High

170121

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.513

High

170129

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

High-throughput

0.513

High

170045

CRKL
Crk-like protein

1

1

High-throughput

0.508

High

170081

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.508

High

170031

SRC
Proto-oncogene tyrosine-protein kinase Src

1

1

Small-scale

0.501

High

134318

MFNG
Beta-1,3-N-acetylglucosaminyltransferase manic fringe

1

1

High-throughput

0.489

High

170025

TSP1
Thrombospondin-1

1

5

Small-scale

0.481

High

170027

ZN688
Zinc finger protein 688

1

3

High-throughput

0.481

High

170035

FBLN1
Fibulin-1

1

4

High-throughput

0.481

High

170038

RXRB
Retinoic acid receptor RXR-beta

1

4

High-throughput

0.481

High

170041

PML
Protein PML

1

4

High-throughput

0.481

High

170052

ADCY7
Adenylate cyclase type 7

1

4

High-throughput

0.481

High

170055

KR103
Keratin-associated protein 10-3

1

11

High-throughput

0.481

High

170066

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.481

High

170076

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

1

High-throughput

0.481

High

170083

LONF1
LON peptidase N-terminal domain and RING finger protein 1

1

5

High-throughput

0.481

High

170102

BCL6B
B-cell CLL/lymphoma 6 member B protein

1

2

High-throughput

0.481

High

170110

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

1

High-throughput

0.481

High

126978

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

1

High-throughput

0.479

High

170005

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

170016

EGFR
Epidermal growth factor receptor

1

1

Small-scale

0.479

High

170017

RASN
GTPase NRas

1

8

High-throughput

0.479

High

170018

RASH
GTPase HRas

1

8

High-throughput

0.479

High

170019

RASK
GTPase KRas

1

7

High-throughput

0.479

High

170021

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

170030

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

170058

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

170013

6PGL
6-phosphogluconolactonase

1

0

High-throughput

0.460

High

170015

F107A
Actin-associated protein FAM107A

1

0

Small-scale

0.460

High

170039

RBL1
Retinoblastoma-like protein 1

1

0

High-throughput

0.460

High

170084

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.460

High

170101

DDIAS
DNA damage-induced apoptosis suppressor protein

1

0

Small-scale

0.460

High

170117

FRAT1
Proto-oncogene FRAT1

1

0

High-throughput

0.460

High

170125

FXL18
F-box/LRR-repeat protein 18

1

0

High-throughput

0.460

High

170033

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

170079

OCLN
Occludin

1

0

Small-scale

0.458

High

170104

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

0

Small-scale

0.458

High

170168

X5D7R7
Major vault protein isoform G

1

1

High-throughput

0.457

High

170169

X5DP31
Aryl-hydrocarbon receptor nuclear translocator 2 isoform E

1

3

High-throughput

0.457

High

81593

B7Z3K1
cDNA FLJ51973

1

1

High-throughput

0.445

High

3380

A0A0S2Z5X4
Zinc finger protein 688 isoform 4

1

3

High-throughput

0.417

High

170099

RETR3
Reticulophagy regulator 3

3

0

High-throughput

0.347

High

170082

RTN1
Reticulon-1

2

0

High-throughput

0.328

High

170144

SPRNG
SREBP regulating gene protein

2

0

High-throughput

0.328

High

170163

FA8A1
Protein FAM8A1

2

0

High-throughput

0.328

High

170167

BOLA1
BolA-like protein 1

2

0

High-throughput

0.328

High

170109

CCER1
Coiled-coil domain-containing glutamate-rich protein 1

2

0

High-throughput

0.317

High

170156

Q9NXX0
ILF3 protein

2

0

High-throughput

0.311

High

170094

SPAT8
Spermatogenesis-associated protein 8

1

0

High-throughput

0.299

High

170034

MK
Midkine

1

0

Small-scale

0.292

High

170086

LCE3C
Late cornified envelope protein 3C

1

0

High-throughput

0.292

High

170087

CJ062
Uncharacterized protein C10orf62

1

0

High-throughput

0.282

High

170103

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.282

High

170106

MUT7
Exonuclease mut-7 homolog

1

0

High-throughput

0.282

High

170124

DHRS1
Dehydrogenase/reductase SDR family member 1

1

0

High-throughput

0.282

High

170139

ENKD1
Enkurin domain-containing protein 1

1

0

High-throughput

0.282

High

170140

PED1A
PC-esterase domain-containing protein 1A

1

0

High-throughput

0.282

High

170105

KTAP2
Keratinocyte-associated protein 2

1

0

High-throughput

0.279

Low

170113

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low

170148

Q9HBR3
GDPD5 protein

1

0

High-throughput

0.268

Low

170142

PPDPF
Pancreatic progenitor cell differentiation and proliferation factor

1

0

Small-scale

0.251

Low

170119

Q96CW7
C4orf42 protein

1

0

High-throughput

0.238

Low

170120

Q96D16
FBXL18 protein

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024