Protein: PPM1D
Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1)

Gene: PPM1D
Organism: Homo sapiens
Interactions: 61
UniProt ID: O15297

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0004674 - protein serine/threonine kinase activity
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

186181

CHK2
Serine/threonine-protein kinase Chk2

2

10

Small-scale

0.825

High

163014

CHK1
Serine/threonine-protein kinase Chk1

1

5

Small-scale

0.724

High

186183

P53
Cellular tumor antigen p53

4

1

Small-scale

0.683

High

186188

H2AX
Histone H2AX

3

4

Small-scale

0.683

High

186211

MK11
Mitogen-activated protein kinase 11

1

13

Small-scale

0.647

High

186194

IMA1
Importin subunit alpha-1

2

2

High-throughput

0.628

High

186218

CDC5L
Cell division cycle 5-like protein

2

5

Small-scale

0.628

High

186208

IMB1
Importin subunit beta-1

2

0

High-throughput

0.602

High

186176

KDM1A
Lysine-specific histone demethylase 1A

1

1

Small-scale

0.578

High

186204

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

3

High-throughput

0.575

High

186199

H31
Histone H3.1

1

3

Small-scale

0.561

High

186200

H33
Histone H3.3

1

3

Small-scale

0.561

High

138594

IMA4
Importin subunit alpha-4

1

2

High-throughput

0.536

High

186173

ACTN4
Alpha-actinin-4

1

1

High-throughput

0.536

High

186177

IMA7
Importin subunit alpha-7

1

2

High-throughput

0.536

High

186182

TBB4A
Tubulin beta-4A chain

1

2

High-throughput

0.536

High

186189

1433B
14-3-3 protein beta/alpha

1

3

High-throughput

0.536

High

186190

PRS7
26S proteasome regulatory subunit 7

1

1

High-throughput

0.536

High

186192

NU153
Nuclear pore complex protein Nup153

1

5

High-throughput

0.536

High

186197

PRS8
26S proteasome regulatory subunit 8

1

1

High-throughput

0.536

High

186205

TBB2A
Tubulin beta-2A chain

1

2

High-throughput

0.536

High

186207

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

High-throughput

0.536

High

186219

PARK7
Parkinson disease protein 7

1

1

High-throughput

0.536

High

186222

TBB6
Tubulin beta-6 chain

1

2

High-throughput

0.536

High

186201

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.530

High

186206

RUNX2
Runt-related transcription factor 2

1

0

Small-scale

0.530

High

186186

ARY2
Arylamine N-acetyltransferase 2

1

0

High-throughput

0.518

High

186215

CASZ1
Zinc finger protein castor homolog 1

1

0

High-throughput

0.518

High

186223

BEX2
Protein BEX2

1

0

High-throughput

0.518

High

186225

NSD3
Histone-lysine N-methyltransferase NSD3

1

0

High-throughput

0.518

High

186229

ERRFI
ERBB receptor feedback inhibitor 1

1

0

High-throughput

0.518

High

186175

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

0

High-throughput

0.513

High

186184

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.513

High

186193

RBP2
E3 SUMO-protein ligase RanBP2

1

0

High-throughput

0.513

High

186195

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

High-throughput

0.513

High

186198

TPM4
Tropomyosin alpha-4 chain

1

0

High-throughput

0.513

High

186202

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.513

High

186203

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

186209

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

High-throughput

0.513

High

186210

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

186212

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

186220

TBA1C
Tubulin alpha-1C chain

1

0

High-throughput

0.513

High

186187

BRAF
Serine/threonine-protein kinase B-raf

1

2

High-throughput

0.506

High

186185

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

186224

RHBT2
Rho-related BTB domain-containing protein 2

1

2

High-throughput

0.494

High

186227

MRC2
C-type mannose receptor 2

1

1

High-throughput

0.494

High

186191

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

Small-scale

0.480

High

186196

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

1

Small-scale

0.479

High

128627

MEN1
Menin

1

0

High-throughput

0.458

High

186174

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

186217

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

Small-scale

0.458

High

186213

P5CR3
Pyrroline-5-carboxylate reductase 3

1

0

High-throughput

0.426

High

186178

GLCE
D-glucuronyl C5-epimerase

1

0

High-throughput

0.282

High

186179

LYPD3
Ly6/PLAUR domain-containing protein 3

1

0

High-throughput

0.282

High

186180

DIRA3
GTP-binding protein Di-Ras3

1

0

High-throughput

0.282

High

186214

ITIH5
Inter-alpha-trypsin inhibitor heavy chain H5

1

0

High-throughput

0.282

High

186216

ESIP1
Epithelial-stromal interaction protein 1

1

0

High-throughput

0.282

High

186228

DKK3
Dickkopf-related protein 3

1

0

High-throughput

0.282

High

186230

OSGI1
Oxidative stress-induced growth inhibitor 1

1

0

High-throughput

0.282

High

186221

NTPCR
Cancer-related nucleoside-triphosphatase

1

0

High-throughput

0.279

Low

186226

TMOD3
Tropomodulin-3

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025