Protein: RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 3)

Gene: RUSD3, RPUSD3
Organism: Homo sapiens
Interactions: 205
UniProt ID: Q6P087

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006397 - mRNA processing
GO:0009982 - pseudouridine synthase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1240332

RM04
Large ribosomal subunit protein uL4m

4

2

High-throughput

0.694

High

532678

CH60
60 kDa heat shock protein, mitochondrial

4

2

High-throughput

0.691

High

1240313

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.656

High

1009226

PRR3
Proline-rich protein 3

3

1

High-throughput

0.643

High

1240366

SYYM
Tyrosine--tRNA ligase, mitochondrial

2

1

High-throughput

0.628

High

278678

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

2

1

High-throughput

0.611

High

1215587

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

2

1

High-throughput

0.611

High

1240315

RT24
Small ribosomal subunit protein uS3m

2

1

High-throughput

0.611

High

239098

ZNRD2
Protein ZNRD2

3

1

High-throughput

0.604

High

1060881

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

0

High-throughput

0.602

High

1240296

NDUF7
Protein arginine methyltransferase NDUFAF7, mitochondrial

2

0

High-throughput

0.602

High

1240298

NIT1
Deaminated glutathione amidase

2

0

High-throughput

0.602

High

1016478

SRSF3
Serine/arginine-rich splicing factor 3

2

2

High-throughput

0.601

High

1196112

RM51
Large ribosomal subunit protein mL51

2

1

High-throughput

0.601

High

1240330

RM13
Large ribosomal subunit protein uL13m

2

2

High-throughput

0.601

High

1240350

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

2

1

High-throughput

0.601

High

1240364

YBOX2
Y-box-binding protein 2

2

5

High-throughput

0.601

High

1240346

NGRN
Neugrin

2

1

Small-scale

0.584

High

485213

ROA1
Heterogeneous nuclear ribonucleoprotein A1

2

2

High-throughput

0.571

High

1059671

KRA11
Keratin-associated protein 1-1

2

2

High-throughput

0.553

High

391294

FRIL
Ferritin light chain

2

1

High-throughput

0.549

High

192597

NUP42
Nucleoporin NUP42

1

1

High-throughput

0.536

High

214305

MSI1H
RNA-binding protein Musashi homolog 1

1

2

High-throughput

0.536

High

725617

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

1

High-throughput

0.536

High

1123318

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.536

High

1148702

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

1

High-throughput

0.536

High

1159971

SRSF7
Serine/arginine-rich splicing factor 7

1

3

High-throughput

0.536

High

1168825

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

2

High-throughput

0.536

High

1213266

RM02
Large ribosomal subunit protein uL2m

1

3

High-throughput

0.536

High

1240300

FABD
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

1

1

High-throughput

0.536

High

1240306

RM50
Large ribosomal subunit protein mL50

1

1

High-throughput

0.536

High

1240314

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

1

High-throughput

0.536

High

1240320

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

1

High-throughput

0.536

High

1240327

RBM42
RNA-binding protein 42

1

2

High-throughput

0.536

High

1240357

SARDH
Sarcosine dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

950297

KR107
Keratin-associated protein 10-7

1

2

High-throughput

0.523

High

48006

RBM47
RNA-binding protein 47

1

0

High-throughput

0.513

High

690511

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.513

High

786137

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.513

High

869180

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

946498

YBEY
Endoribonuclease YbeY

1

0

High-throughput

0.513

High

1030658

ANK2
Ankyrin-2

1

0

High-throughput

0.513

High

1240305

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.513

High

1240309

RM30
Large ribosomal subunit protein uL30m

1

0

High-throughput

0.513

High

1240322

MIPEP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.513

High

1240348

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.513

High

1240358

ZN346
Zinc finger protein 346

1

0

High-throughput

0.513

High

1240319

PASK
PAS domain-containing serine/threonine-protein kinase

1

3

High-throughput

0.489

High

61529

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

75977

B4DEF8
Large ribosomal subunit protein mL45

1

1

High-throughput

0.479

High

127505

NDUS8
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

1

1

High-throughput

0.479

High

143858

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

1

High-throughput

0.479

High

221600

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

1

High-throughput

0.479

High

223836

NDUA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

2

High-throughput

0.479

High

256313

RT14
Small ribosomal subunit protein uS14m

1

2

High-throughput

0.479

High

275313

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

1

High-throughput

0.479

High

275678

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

1

High-throughput

0.479

High

283888

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

2

High-throughput

0.479

High

288963

ERAL1
GTPase Era, mitochondrial

1

2

High-throughput

0.479

High

322255

GLSK
Glutaminase kidney isoform, mitochondrial

1

2

High-throughput

0.479

High

328542

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

1

High-throughput

0.479

High

329290

LETM1
Mitochondrial proton/calcium exchanger protein

1

1

High-throughput

0.479

High

350900

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

443839

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

1

High-throughput

0.479

High

471087

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.479

High

522446

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

6

High-throughput

0.479

High

539195

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

1

High-throughput

0.479

High

539346

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

6

High-throughput

0.479

High

568437

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

617534

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

1

High-throughput

0.479

High

622188

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

1

High-throughput

0.479

High

665616

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

1

High-throughput

0.479

High

666313

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

1

High-throughput

0.479

High

702604

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

1

High-throughput

0.479

High

716570

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

1

High-throughput

0.479

High

716691

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

1

1

High-throughput

0.479

High

717100

ECHM
Enoyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

719445

PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

1

1

High-throughput

0.479

High

733948

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

3

High-throughput

0.479

High

760939

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.479

High

766635

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

788068

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

6

High-throughput

0.479

High

1194823

PPCEL
Prolyl endopeptidase-like

1

1

High-throughput

0.479

High

793718

ETFB
Electron transfer flavoprotein subunit beta

1

1

High-throughput

0.479

High

828813

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

841789

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

856289

IF2M
Translation initiation factor IF-2, mitochondrial

1

4

High-throughput

0.479

High

888714

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

3

High-throughput

0.479

High

890970

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

1

High-throughput

0.479

High

902503

RT29
Small ribosomal subunit protein mS29

1

1

High-throughput

0.479

High

914636

RM12
Large ribosomal subunit protein bL12m

1

2

High-throughput

0.479

High

940013

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

1

High-throughput

0.479

High

941672

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

1

High-throughput

0.479

High

1011106

RT22
Small ribosomal subunit protein mS22

1

1

High-throughput

0.479

High

1011291

RT25
Small ribosomal subunit protein mS25

1

1

High-throughput

0.479

High

1011469

RT10
Small ribosomal subunit protein uS10m

1

2

High-throughput

0.479

High

1011636

RT35
Small ribosomal subunit protein mS35

1

1

High-throughput

0.479

High

1011817

RT05
Small ribosomal subunit protein uS5m

1

2

High-throughput

0.479

High

1012063

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

1

High-throughput

0.479

High

1012528

RT34
Small ribosomal subunit protein mS34

1

1

High-throughput

0.479

High

1012710

RT06
Small ribosomal subunit protein bS6m

1

1

High-throughput

0.479

High

1012867

RT09
Small ribosomal subunit protein uS9m

1

1

High-throughput

0.479

High

1035403

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

3

High-throughput

0.479

High

1087423

GRSF1
G-rich sequence factor 1

1

3

High-throughput

0.479

High

1103993

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.479

High

1138846

SYLM
Leucine--tRNA ligase, mitochondrial

1

5

High-throughput

0.479

High

1162176

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

1

High-throughput

0.479

High

1163464

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

1

High-throughput

0.479

High

1210584

SYVM
Valine--tRNA ligase, mitochondrial

1

5

High-throughput

0.479

High

1240292

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

1

1

High-throughput

0.479

High

1240294

TM10C
tRNA methyltransferase 10 homolog C

1

1

High-throughput

0.479

High

1240295

DHX30
ATP-dependent RNA helicase DHX30

1

1

High-throughput

0.479

High

1240297

ACOT1
Acyl-coenzyme A thioesterase 1

1

3

High-throughput

0.479

High

1240301

RM41
Large ribosomal subunit protein mL41

1

1

High-throughput

0.479

High

1240302

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

1

1

High-throughput

0.479

High

1240304

GUF1
Translation factor GUF1, mitochondrial

1

2

High-throughput

0.479

High

1240308

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

1

1

High-throughput

0.479

High

1240310

RT27
Small ribosomal subunit protein mS27

1

1

High-throughput

0.479

High

1240311

RT31
Small ribosomal subunit protein mS31

1

1

High-throughput

0.479

High

1240312

P5CR2
Pyrroline-5-carboxylate reductase 2

1

3

High-throughput

0.479

High

1240316

PTCD3
Small ribosomal subunit protein mS39

1

1

High-throughput

0.479

High

1240317

MMAB
Corrinoid adenosyltransferase MMAB

1

1

High-throughput

0.479

High

1240318

RCC1L
RCC1-like G exchanging factor-like protein

1

1

Small-scale

0.479

High

1240321

PHB2
Prohibitin-2

1

2

High-throughput

0.479

High

1240323

RNZ2
Zinc phosphodiesterase ELAC protein 2

1

1

High-throughput

0.479

High

1240325

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

1240326

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.479

High

1240329

RM20
Large ribosomal subunit protein bL20m

1

2

High-throughput

0.479

High

1240331

RM09
Large ribosomal subunit protein bL9m

1

1

High-throughput

0.479

High

1240333

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

1240334

DDX24
ATP-dependent RNA helicase DDX24

1

2

High-throughput

0.479

High

1240335

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

3

High-throughput

0.479

High

1240339

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

1240341

RM44
Large ribosomal subunit protein mL44

1

1

High-throughput

0.479

High

1240342

SYCM
Probable cysteine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1240344

RM47
Large ribosomal subunit protein uL29m

1

1

High-throughput

0.479

High

1240345

RT30
Large ribosomal subunit protein mL65

1

1

High-throughput

0.479

High

1240347

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

3

High-throughput

0.479

High

1240349

RM39
Large ribosomal subunit protein mL39

1

1

High-throughput

0.479

High

1240351

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

1

High-throughput

0.479

High

1240354

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

1

High-throughput

0.479

High

1240355

STML2
Stomatin-like protein 2, mitochondrial

1

1

High-throughput

0.479

High

1240359

BCS1
Mitochondrial chaperone BCS1

1

1

High-throughput

0.479

High

1240360

RT33
Small ribosomal subunit protein mS33

1

1

High-throughput

0.479

High

1240361

RT28
Small ribosomal subunit protein bS1m

1

1

High-throughput

0.479

High

1240362

RT17
Small ribosomal subunit protein uS17m

1

1

High-throughput

0.479

High

1240363

RT07
Small ribosomal subunit protein uS7m

1

2

High-throughput

0.479

High

1240367

RT02
Small ribosomal subunit protein uS2m

1

2

High-throughput

0.479

High

1240368

RT16
Small ribosomal subunit protein bS16m

1

2

High-throughput

0.479

High

1240369

RT23
Small ribosomal subunit protein mS23

1

1

High-throughput

0.479

High

1240370

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.479

High

1240371

RT18B
Small ribosomal subunit protein mS40

1

1

High-throughput

0.479

High

1240372

NFS1
Cysteine desulfurase

1

1

High-throughput

0.479

High

360434

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.458

High

401000

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

472823

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

962966

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

1038640

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

0

High-throughput

0.458

High

1090437

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

1240289

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

0

High-throughput

0.458

High

1240291

OLFM4
Olfactomedin-4

1

0

High-throughput

0.458

High

135247

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

2

High-throughput

0.445

High

430040

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

1234416

MRM1
rRNA methyltransferase 1, mitochondrial

1

2

High-throughput

0.445

High

1240293

LN28B
Protein lin-28 homolog B

1

5

High-throughput

0.445

High

949904

KR103
Keratin-associated protein 10-3

1

2

High-throughput

0.439

High

372316

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.437

High

406286

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.437

High

581119

RAC2
Ras-related C3 botulinum toxin substrate 2

1

1

High-throughput

0.437

High

606856

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.437

High

955301

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.437

High

978090

RHOB
Rho-related GTP-binding protein RhoB

1

2

High-throughput

0.437

High

1240290

POTEE
POTE ankyrin domain family member E

1

1

High-throughput

0.437

High

1240303

FBXW8
F-box/WD repeat-containing protein 8

1

2

High-throughput

0.437

High

1240337

RHOJ
Rho-related GTP-binding protein RhoJ

1

3

High-throughput

0.437

High

1240343

RHOF
Rho-related GTP-binding protein RhoF

1

3

High-throughput

0.437

High

1240353

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

653386

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1240307

PCD20
Protocadherin-20

1

0

High-throughput

0.426

High

1042633

UPAR
Urokinase plasminogen activator surface receptor

3

0

High-throughput

0.347

High

1240340

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

3

0

High-throughput

0.347

High

402949

ANXA1
Annexin A1

2

0

High-throughput

0.328

High

70287

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1145991

K1H1
Keratin, type I cuticular Ha1

1

0

High-throughput

0.299

High

396334

ESR1
Estrogen receptor

2

0

High-throughput

0.298

High

703948

DUS1
Dual specificity protein phosphatase 1

2

0

High-throughput

0.298

High

260768

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.279

Low

366420

FA12
Coagulation factor XII

1

0

High-throughput

0.279

Low

945252

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.279

Low

1240336

CAD23
Cadherin-23

1

0

High-throughput

0.279

Low

1240373

EMIL1
EMILIN-1

1

0

High-throughput

0.279

Low

889439

CLK1
Dual specificity protein kinase CLK1

1

0

High-throughput

0.261

Low

1240352

TFP11
Tuftelin-interacting protein 11

1

0

High-throughput

0.251

Low

315691

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

755491

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.249

Low

1137776

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.249

Low

1197624

MIDN
Midnolin

1

0

High-throughput

0.249

Low

1240299

NUDC3
NudC domain-containing protein 3

1

0

High-throughput

0.249

Low

1240324

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.249

Low

1240328

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.249

Low

1240338

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1240356

FBW1B
F-box/WD repeat-containing protein 11

1

0

High-throughput

0.249

Low

1240365

SGT1
Protein SGT1 homolog

1

0

High-throughput

0.249

Low

844805

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.232

Low

1054607

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025