Protein: GUAA
GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase)

Gene: GUAA, GMPS
Organism: Homo sapiens
Interactions: 111
UniProt ID: P49915

Gene Ontology (top 5):
GO:0003921 - GMP synthase activity
GO:0003922 - GMP synthase (glutamine-hydrolyzing) activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006177 - GMP biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

836660

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

10

4

Small-scale

0.756

High

226869

PRKN
E3 ubiquitin-protein ligase parkin

3

7

High-throughput

0.640

High

584905

RO52
E3 ubiquitin-protein ligase TRIM21

3

1

Small-scale

0.640

High

664052

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

244123

BRD4
Bromodomain-containing protein 4

3

4

High-throughput

0.585

High

386322

P53
Cellular tumor antigen p53

2

2

Small-scale

0.584

High

280366

GLRX3
Glutaredoxin-3

1

2

Small-scale

0.552

High

581549

VCAM1
Vascular cell adhesion protein 1

2

2

High-throughput

0.549

High

836640

CUL3
Cullin-3

1

1

High-throughput

0.536

High

836686

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

1

High-throughput

0.536

High

836687

AGO2
Protein argonaute-2

1

2

High-throughput

0.536

High

836694

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.536

High

641344

PAX6
Paired box protein Pax-6

1

0

High-throughput

0.513

High

836633

MTPN
Myotrophin

1

0

High-throughput

0.513

High

836649

KIF7
Kinesin-like protein KIF7

1

0

High-throughput

0.513

High

836684

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.493

High

176145

PPM1G
Protein phosphatase 1G

1

2

High-throughput

0.489

High

836665

RMC1
Regulator of MON1-CCZ1 complex

1

1

High-throughput

0.489

High

135403

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

3

High-throughput

0.479

High

160452

AURKA
Aurora kinase A

1

4

High-throughput

0.479

High

294539

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

298283

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

384496

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

455222

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

487237

ANDR
Androgen receptor

1

2

High-throughput

0.479

High

503692

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

684520

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.479

High

779026

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

827868

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

3

High-throughput

0.479

High

832239

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

835589

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.479

High

836631

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.479

High

836634

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

836635

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

836636

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

836638

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

836639

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

1

High-throughput

0.479

High

836641

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

3

High-throughput

0.479

High

836643

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

836645

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

836650

DCAF6
DDB1- and CUL4-associated factor 6

1

3

High-throughput

0.479

High

836657

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

836658

RIN3
Ras and Rab interactor 3

1

2

High-throughput

0.479

High

836659

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

836662

FBX32
F-box only protein 32

1

1

Small-scale

0.479

High

836663

ARMC5
Armadillo repeat-containing protein 5

1

2

High-throughput

0.479

High

836664

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.479

High

836674

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

5

High-throughput

0.479

High

836680

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

836682

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

836685

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

836690

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

1

High-throughput

0.479

High

133933

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

674302

PURA2
Adenylosuccinate synthetase isozyme 2

1

0

High-throughput

0.458

High

742134

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

836637

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

836652

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

836655

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

836672

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

836688

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

836692

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

717567

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

836651

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

836666

OTUB1
Ubiquitin thioesterase OTUB1

1

1

High-throughput

0.445

High

836676

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

6

High-throughput

0.445

High

836678

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

6

High-throughput

0.445

High

168173

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

1

High-throughput

0.439

High

165829

KDM6B
Lysine-specific demethylase 6B

1

2

Small-scale

0.437

High

346245

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

351310

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

1

High-throughput

0.437

High

354367

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.437

High

488165

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.437

High

530511

ITA4
Integrin alpha-4

1

2

High-throughput

0.437

High

552241

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

569396

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.437

High

575340

EGR1
Early growth response protein 1

1

1

High-throughput

0.437

High

650681

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

719979

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

749234

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.437

High

823702

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

836632

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.437

High

836642

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

836647

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

836653

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

836654

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.437

High

836656

MGDP1
Magnesium-dependent phosphatase 1

1

1

High-throughput

0.437

High

836661

TP4A1
Protein tyrosine phosphatase type IVA 1

1

1

High-throughput

0.437

High

836669

CIC
Protein capicua homolog

1

2

High-throughput

0.437

High

836675

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

836677

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.437

High

836679

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

836681

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

6

High-throughput

0.437

High

836683

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.437

High

836689

TRI33
E3 ubiquitin-protein ligase TRIM33

1

5

High-throughput

0.437

High

836691

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

836693

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

371378

ANGI
Angiogenin

1

0

High-throughput

0.426

High

401647

JUN
Transcription factor Jun

1

3

High-throughput

0.407

High

831105

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

64001

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

362946

FINC
Fibronectin

1

0

High-throughput

0.279

Low

836670

GPX7
Glutathione peroxidase 7

1

0

High-throughput

0.279

Low

836671

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.279

Low

836673

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

836646

TCAL1
Transcription elongation factor A protein-like 1

1

0

High-throughput

0.269

Low

836630

TXTP
Tricarboxylate transport protein, mitochondrial

1

0

High-throughput

0.249

Low

836644

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.249

Low

836648

CRY1
Cryptochrome-1

1

0

High-throughput

0.249

Low

836667

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

836668

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

0

Small-scale

0.249

Low

563288

ZNF16
Zinc finger protein 16

1

0

Small-scale

0.238

Low


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Last updated: 15 Jul 2024