Protein: SPTA1
Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin)

Gene: SPTA1
Organism: Homo sapiens
Interactions: 88
UniProt ID: P02549

Gene Ontology (top 5):
GO:0002260 - lymphocyte homeostasis
GO:0003786 - actin lateral binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005509 - calcium ion binding
GO:0005826 - actomyosin contractile ring

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

360607

SPTB1
Spectrin beta chain, erythrocytic

5

18

Small-scale

0.920

High

360612

ANK1
Ankyrin-1

2

20

Small-scale

0.778

High

337296

ABL1
Tyrosine-protein kinase ABL1

1

18

Small-scale

0.724

High

360638

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

17

Small-scale

0.692

High

360621

SHC1
SHC-transforming protein 1

1

14

High-throughput

0.691

High

360640

BTK
Tyrosine-protein kinase BTK

1

18

Small-scale

0.691

High

360650

ABI1
Abl interactor 1

1

13

Small-scale

0.653

High

360644

PLEC
Plectin

1

20

Small-scale

0.647

High

360601

P53
Cellular tumor antigen p53

1

7

High-throughput

0.618

High

360632

RD23B
UV excision repair protein RAD23 homolog B

1

15

Small-scale

0.618

High

360664

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

18

Small-scale

0.618

High

318767

K2C75
Keratin, type II cytoskeletal 75

2

4

High-throughput

0.606

High

360659

PKP2
Plakophilin-2

2

14

High-throughput

0.606

High

360667

EXOS5
Exosome complex component RRP46

2

1

High-throughput

0.606

High

176526

FANCA
Fanconi anemia group A protein

2

2

Small-scale

0.584

High

360600

SPTA1
Spectrin alpha chain, erythrocytic 1

1

17

Small-scale

0.575

High

360651

CC185
Coiled-coil domain-containing protein 185

2

11

High-throughput

0.553

High

360658

THIOM
Thioredoxin, mitochondrial

2

5

High-throughput

0.553

High

360668

TSH2
Teashirt homolog 2

2

4

High-throughput

0.553

High

360616

CBL
E3 ubiquitin-protein ligase CBL

1

9

High-throughput

0.536

High

360660

CP250
Centrosome-associated protein CEP250

1

20

High-throughput

0.536

High

360657

XPF
DNA repair endonuclease XPF

2

2

Small-scale

0.533

High

360605

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.515

High

152220

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

3

Small-scale

0.501

High

360618

1433T
14-3-3 protein theta

1

20

High-throughput

0.501

High

360624

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

1

Small-scale

0.501

High

360669

SL9A2
Sodium/hydrogen exchanger 2

1

1

Small-scale

0.501

High

360655

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

16

High-throughput

0.489

High

174337

FANCG
Fanconi anemia group G protein

1

1

Small-scale

0.479

High

348458

RASN
GTPase NRas

1

20

High-throughput

0.479

High

349049

RASH
GTPase HRas

1

20

High-throughput

0.479

High

349783

RASK
GTPase KRas

1

20

High-throughput

0.479

High

359549

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

10

Small-scale

0.479

High

360602

A4
Amyloid-beta precursor protein

1

4

Small-scale

0.479

High

360604

RSSA
Small ribosomal subunit protein uS2

1

1

Small-scale

0.479

High

360606

MYBB
Myb-related protein B

1

9

Small-scale

0.479

High

360608

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.479

High

360609

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.479

High

360610

EZRI
Ezrin

1

20

Small-scale

0.479

High

360613

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

1

Small-scale

0.479

High

360622

PML
Protein PML

1

14

Small-scale

0.479

High

360625

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

2

High-throughput

0.479

High

360627

EMD
Emerin

1

1

Small-scale

0.479

High

360631

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

14

Small-scale

0.479

High

360634

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

10

Small-scale

0.479

High

360636

ACTS
Actin, alpha skeletal muscle

1

20

Small-scale

0.479

High

360637

FANCC
Fanconi anemia group C protein

1

1

Small-scale

0.479

High

360641

RAD51
DNA repair protein RAD51 homolog 1

1

4

Small-scale

0.479

High

360643

CUL4A
Cullin-4A

1

10

High-throughput

0.479

High

360646

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

1

Small-scale

0.479

High

360662

FACD2
Fanconi anemia group D2 protein

1

9

Small-scale

0.479

High

360665

GAN
Gigaxonin

1

7

High-throughput

0.479

High

360666

FANCF
Fanconi anemia group F protein

1

1

Small-scale

0.479

High

360671

E41L3
Band 4.1-like protein 3

1

15

Small-scale

0.479

High

360672

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

1

Small-scale

0.479

High

360673

NCOA3
Nuclear receptor coactivator 3

1

4

Small-scale

0.479

High

360645

H31T
Histone H3.1t

1

6

High-throughput

0.470

High

360642

Q0VAL7
C21orf58 protein

1

1

High-throughput

0.470

High

360623

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.458

High

360626

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

360653

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

360628

VASP
Vasodilator-stimulated phosphoprotein

1

13

Small-scale

0.457

High

360652

ENAH
Protein enabled homolog

1

20

Small-scale

0.457

High

360670

EVL
Ena/VASP-like protein

1

15

Small-scale

0.457

High

360649

CLC4G
C-type lectin domain family 4 member G

1

11

Small-scale

0.445

High

360633

CU058
Uncharacterized protein C21orf58

1

1

High-throughput

0.439

High

207139

XRCC2
DNA repair protein XRCC2

1

4

Small-scale

0.437

High

329217

AGR2
Anterior gradient protein 2 homolog

1

7

High-throughput

0.437

High

360611

RFA2
Replication protein A 32 kDa subunit

1

13

Small-scale

0.437

High

360614

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

3

Small-scale

0.437

High

360615

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

Small-scale

0.437

High

360619

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

10

Small-scale

0.437

High

360620

ERCC5
DNA excision repair protein ERCC-5

1

1

Small-scale

0.437

High

360629

SMCA2
Probable global transcription activator SNF2L2

1

3

Small-scale

0.437

High

360630

SMCA4
Transcription activator BRG1

1

3

Small-scale

0.437

High

360635

H4
Histone H4

1

6

High-throughput

0.437

High

360639

ERCC6
DNA excision repair protein ERCC-6

1

4

Small-scale

0.437

High

360656

RAD50
DNA repair protein RAD50

1

20

Small-scale

0.437

High

360661

FANCJ
Fanconi anemia group J protein

1

1

Small-scale

0.437

High

68628

CMA1B
Ciliary microtubule associated protein 1B

2

0

High-throughput

0.316

High

157275

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

2

0

High-throughput

0.316

High

360647

ZN326
DBIRD complex subunit ZNF326

2

0

High-throughput

0.316

High

360654

G45IP
Large ribosomal subunit protein mL64

2

0

High-throughput

0.316

High

360663

DGC6L
Protein DGCR6L

2

0

High-throughput

0.316

High

360603

ERCC1
DNA excision repair protein ERCC-1

1

0

Small-scale

0.249

Low

360617

XPA
DNA repair protein complementing XP-A cells

1

0

Small-scale

0.249

Low

360648

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024