Protein: SIVA
Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP)

Gene: SIVA, SIVA1
Organism: Homo sapiens
Interactions: 49
UniProt ID: O15304

Gene Ontology (top 5):
GO:0001618 - virus receptor activity
GO:0005164 - tumor necrosis factor receptor binding
GO:0005175 - CD27 receptor binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

186240

PCNA
Proliferating cell nuclear antigen

3

1

Small-scale

0.665

High

186255

B2CL1
Bcl-2-like protein 1

2

2

Small-scale

0.646

High

186251

XIAP
E3 ubiquitin-protein ligase XIAP

3

0

Small-scale

0.640

High

186243

CD27
CD27 antigen

2

0

Small-scale

0.613

High

186241

STMN1
Stathmin

2

0

Small-scale

0.605

High

186245

AQP1
Aquaporin-1

2

0

High-throughput

0.580

High

186254

CREB5
Cyclic AMP-responsive element-binding protein 5

2

0

High-throughput

0.580

High

186263

P20D2
Xaa-Arg dipeptidase

2

0

High-throughput

0.580

High

186275

ZN446
Zinc finger protein 446

2

0

High-throughput

0.580

High

186271

LPAR2
Lysophosphatidic acid receptor 2

1

1

Small-scale

0.561

High

186236

P53
Cellular tumor antigen p53

2

0

Small-scale

0.559

High

186252

MDM2
E3 ubiquitin-protein ligase Mdm2

2

0

Small-scale

0.559

High

186247

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

Small-scale

0.554

High

186244

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

1

Small-scale

0.552

High

186232

MEFV
Pyrin

1

0

Small-scale

0.549

High

186273

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

Small-scale

0.537

High

186258

PCBP1
Poly(rC)-binding protein 1

1

0

Small-scale

0.529

High

186268

FOXP3
Forkhead box protein P3

1

0

Small-scale

0.529

High

186272

PXMP2
Peroxisomal membrane protein 2

1

0

Small-scale

0.529

High

186239

BCL2
Apoptosis regulator Bcl-2

1

2

Small-scale

0.527

High

2858

A0A0C4DG38
Inhibitor of growth family member 3

1

1

High-throughput

0.515

High

186235

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.504

High

186248

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

High-throughput

0.501

High

186266

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

1

High-throughput

0.501

High

186233

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

Small-scale

0.493

High

186276

ING3
Inhibitor of growth protein 3

1

1

High-throughput

0.481

High

186237

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

186250

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

0

Small-scale

0.480

High

186261

RHOU
Rho-related GTP-binding protein RhoU

1

0

High-throughput

0.480

High

186234

S1PR4
Sphingosine 1-phosphate receptor 4

1

1

Small-scale

0.479

High

186253

BEX3
Protein BEX3

1

0

High-throughput

0.460

High

186269

TXNIP
Thioredoxin-interacting protein

1

0

Small-scale

0.460

High

186256

TRAF2
TNF receptor-associated factor 2

1

0

Small-scale

0.458

High

186257

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

0

Small-scale

0.458

High

186270

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

186274

FAIM1
Fas apoptotic inhibitory molecule 1

1

0

Small-scale

0.458

High

186277

UXT
Protein UXT

1

0

Small-scale

0.458

High

186278

TNR18
Tumor necrosis factor receptor superfamily member 18

1

1

Small-scale

0.437

High

186249

HXA1
Homeobox protein Hox-A1

2

0

High-throughput

0.316

High

186259

CB068
UPF0561 protein C2orf68

2

0

High-throughput

0.316

High

186260

KR261
Keratin-associated protein 26-1

2

0

High-throughput

0.316

High

186262

AP2D
Transcription factor AP-2-delta

2

0

High-throughput

0.316

High

186264

CTSR1
Cation channel sperm-associated protein 1

2

0

High-throughput

0.316

High

186265

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.316

High

186246

ABL2
Tyrosine-protein kinase ABL2

1

0

Small-scale

0.292

High

186267

SSBP3
Single-stranded DNA-binding protein 3

1

0

Small-scale

0.292

High

185052

TELT
Telethonin

1

0

Small-scale

0.275

Low

186242

TA2R
Thromboxane A2 receptor

1

0

Small-scale

0.249

Low

186238

MYZAP
Myocardial zonula adherens protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025