Protein: CD4
T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)

Gene: CD4
Organism: Homo sapiens
Interactions: 98
UniProt ID: P01730

Gene Ontology (top 5):
GO:0001618 - virus receptor activity
GO:0001934 - positive regulation of protein phosphorylation
GO:0002250 - adaptive immune response
GO:0004888 - transmembrane signaling receptor activity
GO:0005201 - extracellular matrix structural constituent

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

378796

CD4
T-cell surface glycoprotein CD4

2

0

Small-scale

0.749

High

378805

LCK
Tyrosine-protein kinase Lck

8

1

Small-scale

0.744

High

378854

CXCR4
C-X-C chemokine receptor type 4

3

3

Small-scale

0.656

High

378872

VPP1
V-type proton ATPase 116 kDa subunit a 1

2

1

High-throughput

0.628

High

378886

VPP2
V-type proton ATPase 116 kDa subunit a 2

2

1

High-throughput

0.628

High

378816

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

0

Small-scale

0.614

High

378867

VAMP3
Vesicle-associated membrane protein 3

2

0

High-throughput

0.602

High

378869

POGZ
Pogo transposable element with ZNF domain

2

0

High-throughput

0.602

High

378870

K319L
Dyslexia-associated protein KIAA0319-like protein

2

0

High-throughput

0.602

High

378877

ARV1
Protein ARV1

2

0

High-throughput

0.602

High

378878

CD320
CD320 antigen

2

0

High-throughput

0.602

High

378849

CCR5
C-C chemokine receptor type 5

2

3

Small-scale

0.588

High

378862

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

1

Small-scale

0.561

High

378861

U119A
Protein unc-119 homolog A

1

0

Small-scale

0.537

High

378810

ADRB2
Beta-2 adrenergic receptor

1

0

Small-scale

0.529

High

187241

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.518

High

378813

MDR1
ATP-dependent translocase ABCB1

1

0

High-throughput

0.518

High

378825

TMM11
Transmembrane protein 11, mitochondrial

1

0

High-throughput

0.513

High

378837

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.513

High

186235

SIVA
Apoptosis regulatory protein Siva

1

0

Small-scale

0.504

High

378836

AA2AR
Adenosine receptor A2a

1

1

Small-scale

0.501

High

378798

GCR
Glucocorticoid receptor

1

0

Small-scale

0.493

High

378819

LEG1
Galectin-1

1

0

Small-scale

0.493

High

378855

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.493

High

378857

PCDH1
Protocadherin-1

1

0

High-throughput

0.493

High

378824

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

378885

SHLB1
Endophilin-B1

1

0

High-throughput

0.493

High

378868

MK14
Mitogen-activated protein kinase 14

1

0

Small-scale

0.480

High

141259

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

Small-scale

0.479

High

378797

ANXA1
Annexin A1

1

2

Small-scale

0.479

High

378808

ANXA2
Annexin A2

1

2

Small-scale

0.479

High

378811

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.479

High

378812

ANXA6
Annexin A6

1

2

Small-scale

0.479

High

378814

HS90B
Heat shock protein HSP 90-beta

1

1

Small-scale

0.479

High

378817

VIME
Vimentin

1

1

Small-scale

0.479

High

378826

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

Small-scale

0.479

High

378830

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

2

Small-scale

0.479

High

378835

CD82
CD82 antigen

1

1

Small-scale

0.479

High

378844

ZAP70
Tyrosine-protein kinase ZAP-70

1

3

Small-scale

0.479

High

378845

KSYK
Tyrosine-protein kinase SYK

1

3

Small-scale

0.479

High

378846

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

2

Small-scale

0.479

High

378853

CD81
CD81 antigen

1

1

Small-scale

0.479

High

378863

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

2

Small-scale

0.479

High

378865

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

378866

IMB1
Importin subunit beta-1

1

1

Small-scale

0.479

High

169380

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

Small-scale

0.458

High

378799

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

Small-scale

0.458

High

378800

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

0

Small-scale

0.458

High

378806

ENOA
Alpha-enolase

1

0

Small-scale

0.458

High

378807

NPM
Nucleophosmin

1

0

Small-scale

0.458

High

378809

TBB5
Tubulin beta chain

1

0

Small-scale

0.458

High

378815

NEP
Neprilysin

1

0

Small-scale

0.458

High

378818

RSSA
Small ribosomal subunit protein uS2

1

0

Small-scale

0.458

High

378821

CH60
60 kDa heat shock protein, mitochondrial

1

0

Small-scale

0.458

High

378822

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

378829

NUCL
Nucleolin

1

0

Small-scale

0.458

High

378832

EF1B
Elongation factor 1-beta

1

0

Small-scale

0.458

High

378834

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

0

Small-scale

0.458

High

378839

PHB1
Prohibitin 1

1

0

Small-scale

0.458

High

378841

RS19
Small ribosomal subunit protein eS19

1

0

Small-scale

0.458

High

378842

EPS15
Epidermal growth factor receptor substrate 15

1

0

Small-scale

0.458

High

378851

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

378874

RANB9
Ran-binding protein 9

1

0

Small-scale

0.458

High

378883

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

Small-scale

0.458

High

378820

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

2

Small-scale

0.437

High

378831

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

Small-scale

0.437

High

378838

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

Small-scale

0.437

High

378864

IF4A2
Eukaryotic initiation factor 4A-II

1

2

Small-scale

0.437

High

378871

TNPO1
Transportin-1

1

1

Small-scale

0.437

High

378884

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

2

Small-scale

0.437

High

66572

CC85C
Coiled-coil domain-containing protein 85C

2

0

High-throughput

0.328

High

378873

SAAL1
Protein SAAL1

2

0

High-throughput

0.328

High

378882

EI2BD
Translation initiation factor eIF2B subunit delta

2

0

High-throughput

0.328

High

378881

SPG21
Maspardin

1

0

Small-scale

0.288

High

378875

UBL7
Ubiquitin-like protein 7

1

0

High-throughput

0.282

High

378879

EI2BG
Translation initiation factor eIF2B subunit gamma

1

0

High-throughput

0.279

Low

378803

K1C18
Keratin, type I cytoskeletal 18

1

0

High-throughput

0.269

Low

378804

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.269

Low

378823

PIP
Prolactin-inducible protein

1

0

Small-scale

0.261

Low

187620

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

Small-scale

0.249

Low

378801

RLA1
Large ribosomal subunit protein P1

1

0

Small-scale

0.249

Low

378802

RLA0
Large ribosomal subunit protein uL10

1

0

Small-scale

0.249

Low

378827

RL7
Large ribosomal subunit protein uL30

1

0

Small-scale

0.249

Low

378828

ML12A
Myosin regulatory light chain 12A

1

0

Small-scale

0.249

Low

378833

RS12
Small ribosomal subunit protein eS12

1

0

Small-scale

0.249

Low

378840

RL22
Large ribosomal subunit protein eL22

1

0

Small-scale

0.249

Low

378843

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

Small-scale

0.249

Low

378847

RS9
Small ribosomal subunit protein uS4

1

0

Small-scale

0.249

Low

378848

RS10
Small ribosomal subunit protein eS10

1

0

Small-scale

0.249

Low

378850

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.249

Low

378852

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

Small-scale

0.249

Low

378856

RL18
Large ribosomal subunit protein eL18

1

0

Small-scale

0.249

Low

378858

SSRP1
FACT complex subunit SSRP1

1

0

Small-scale

0.249

Low

378859

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

Small-scale

0.249

Low

378860

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

0

Small-scale

0.249

Low

378876

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

Small-scale

0.249

Low

378880

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025