Protein: SMYD1
Histone-lysine N-methyltransferase SMYD1 (EC 2.1.1.354) (SET and MYND domain-containing protein 1)

Gene: SMYD1
Organism: Homo sapiens
Interactions: 55
UniProt ID: Q8NB12

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0007507 - heart development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1245004

SPSB3
SPRY domain-containing SOCS box protein 3

2

2

High-throughput

0.811

High

1311750

HOMEZ
Homeobox and leucine zipper protein Homez

4

1

High-throughput

0.700

High

1332942

SMYD3
Histone-lysine N-methyltransferase SMYD3

1

1

High-throughput

0.691

High

155006

BHE40
Class E basic helix-loop-helix protein 40

5

0

High-throughput

0.691

High

720125

PURA2
Adenylosuccinate synthetase isozyme 2

4

0

High-throughput

0.679

High

67561

MYH7B
Myosin-7B

3

2

High-throughput

0.675

High

1332925

ZBT44
Zinc finger and BTB domain-containing protein 44

3

5

High-throughput

0.664

High

1239454

H3C
Histone H3.3C

1

7

High-throughput

0.656

High

1332932

MEP50
Methylosome protein WDR77

1

1

High-throughput

0.656

High

451220

NFL
Neurofilament light polypeptide

2

1

High-throughput

0.606

High

1332933

HDHD3
Haloacid dehalogenase-like hydrolase domain-containing protein 3

2

2

High-throughput

0.606

High

1332936

BACH2
Transcription regulator protein BACH2

2

2

High-throughput

0.606

High

1332941

ZBTB3
Zinc finger and BTB domain-containing protein 3

2

3

High-throughput

0.606

High

1332944

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

2

1

High-throughput

0.606

High

1332950

SNX11
Sorting nexin-11

2

1

High-throughput

0.606

High

1007958

PO6F2
POU domain, class 6, transcription factor 2

2

0

High-throughput

0.580

High

1044679

ARI5A
AT-rich interactive domain-containing protein 5A

2

0

High-throughput

0.580

High

1191538

TBRG1
Transforming growth factor beta regulator 1

2

0

High-throughput

0.580

High

1235268

CMI2A
Ciliary microtubule inner protein 2A

2

0

High-throughput

0.580

High

1289420

FA83A
Protein FAM83A

2

0

High-throughput

0.580

High

1332927

KI16B
Kinesin-like protein KIF16B

2

0

High-throughput

0.580

High

1332929

MDFI
MyoD family inhibitor

2

0

High-throughput

0.580

High

1332930

SPAG8
Sperm-associated antigen 8

2

0

High-throughput

0.580

High

1332935

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.580

High

1332945

HM20A
High mobility group protein 20A

2

0

High-throughput

0.580

High

1332948

F86C1
Putative protein FAM86C1P

2

0

High-throughput

0.580

High

1332931

RBM4B
RNA-binding protein 4B

1

0

High-throughput

0.549

High

564066

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

996774

TBA1B
Tubulin alpha-1B chain

1

2

High-throughput

0.536

High

1332937

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

2

High-throughput

0.536

High

1232470

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

1287237

Q86TH3
Dishevelled, dsh homolog 1

1

1

High-throughput

0.515

High

1013159

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.513

High

1097430

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.513

High

1312840

OCAT1
POU domain class 2-associating factor 2

1

0

High-throughput

0.486

High

1332928

LENG8
Leukocyte receptor cluster member 8

1

0

High-throughput

0.486

High

894029

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

1244705

TTC33
Tetratricopeptide repeat protein 33

1

2

High-throughput

0.464

High

551160

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

159375

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

1

High-throughput

0.439

High

1211866

CHCH9
Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial

1

0

High-throughput

0.426

High

1332934

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

3

0

High-throughput

0.345

High

1332943

F204A
Protein FAM204A

3

0

High-throughput

0.345

High

1081669

SCRN3
Secernin-3

2

0

High-throughput

0.328

High

1258140

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

1332926

KRT35
Keratin, type I cuticular Ha5

2

0

High-throughput

0.316

High

1332939

RSH6A
Radial spoke head protein 6 homolog A

2

0

High-throughput

0.316

High

1332940

CFA68
Cilia- and flagella-associated protein 68

2

0

High-throughput

0.316

High

1332947

DISC1
Disrupted in schizophrenia 1 protein

2

0

High-throughput

0.316

High

412968

CPNS1
Calpain small subunit 1

1

0

High-throughput

0.279

Low

1332938

CF263
Cilia- and flagella-associated protein 263

1

0

High-throughput

0.265

Low

1332946

CK016
Uncharacterized protein C11orf16

1

0

High-throughput

0.265

Low

1332949

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

1

0

High-throughput

0.265

Low

1316024

PRR22
Proline-rich protein 22

1

0

High-throughput

0.251

Low

1328364

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025