Protein: UBP54
Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54)

Gene: UBP54, USP54
Organism: Homo sapiens
Interactions: 228
UniProt ID: Q70EL1

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0006508 - proteolysis
GO:0016579 - protein deubiquitination
GO:0061578 - K63-linked deubiquitinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

288443

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

0

High-throughput

0.742

High

1258209

FBW1B
F-box/WD repeat-containing protein 11

2

1

High-throughput

0.675

High

992816

RACK1
Small ribosomal subunit protein RACK1

2

0

High-throughput

0.655

High

927373

ATX1
Ataxin-1

4

1

High-throughput

0.641

High

966516

1433G
14-3-3 protein gamma

4

9

High-throughput

0.630

High

1049469

1433F
14-3-3 protein eta

4

9

High-throughput

0.630

High

505576

ATX1L
Ataxin-1-like

3

1

High-throughput

0.611

High

729986

1433B
14-3-3 protein beta/alpha

3

9

High-throughput

0.609

High

1258125

SKAP1
Src kinase-associated phosphoprotein 1

3

1

High-throughput

0.609

High

1258211

CELA1
Chymotrypsin-like elastase family member 1

2

0

High-throughput

0.602

High

109433

G5E9A7
DM1 locus, WD repeat containing

1

2

High-throughput

0.594

High

508180

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.579

High

350714

NOE2
Noelin-2

2

1

High-throughput

0.574

High

1092988

CDC16
Cell division cycle protein 16 homolog

2

1

High-throughput

0.574

High

1258224

ASB3
Ankyrin repeat and SOCS box protein 3

2

1

High-throughput

0.574

High

990394

1433Z
14-3-3 protein zeta/delta

2

9

High-throughput

0.558

High

225619

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

1

High-throughput

0.553

High

254485

PLPL9
85/88 kDa calcium-independent phospholipase A2

2

1

High-throughput

0.553

High

274015

CREST
Calcium-responsive transactivator

2

1

High-throughput

0.553

High

1061748

TLE5
TLE family member 5

2

1

High-throughput

0.553

High

1108837

BFSP2
Phakinin

2

2

High-throughput

0.553

High

1258116

KCTD9
BTB/POZ domain-containing protein KCTD9

2

1

High-throughput

0.553

High

1258124

IGFN1
Immunoglobulin-like and fibronectin type III domain-containing protein 1

2

1

High-throughput

0.553

High

1258129

CHERP
Calcium homeostasis endoplasmic reticulum protein

2

1

High-throughput

0.553

High

1258147

LNX1
E3 ubiquitin-protein ligase LNX

2

1

High-throughput

0.553

High

1258154

SHC3
SHC-transforming protein 3

2

3

High-throughput

0.553

High

1258156

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

1

High-throughput

0.553

High

1258177

CAR10
Caspase recruitment domain-containing protein 10

2

2

High-throughput

0.553

High

1258184

RN208
RING finger protein 208

2

1

High-throughput

0.553

High

1258206

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

1

High-throughput

0.553

High

1258207

CDC23
Cell division cycle protein 23 homolog

2

1

High-throughput

0.553

High

1258214

ZN148
Zinc finger protein 148

2

1

High-throughput

0.553

High

1047920

TLE2
Transducin-like enhancer protein 2

1

3

High-throughput

0.553

High

1226930

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.553

High

1258216

FBW1A
F-box/WD repeat-containing protein 1A

1

1

High-throughput

0.553

High

1007102

TCPB
T-complex protein 1 subunit beta

2

2

High-throughput

0.549

High

1258204

TSP50
Probable threonine protease PRSS50

1

1

High-throughput

0.536

High

790063

ZEB1
Zinc finger E-box-binding homeobox 1

2

1

Small-scale

0.533

High

1258218

NINL
Ninein-like protein

2

4

High-throughput

0.533

High

1004104

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.517

High

1258135

WDTC1
WD and tetratricopeptide repeats protein 1

1

0

High-throughput

0.517

High

1258176

LST8
Target of rapamycin complex subunit LST8

1

0

High-throughput

0.517

High

606011

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.513

High

777502

K22E
Keratin, type II cytoskeletal 2 epidermal

1

3

High-throughput

0.489

High

1090742

TRAF2
TNF receptor-associated factor 2

1

3

High-throughput

0.489

High

1258137

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

1

High-throughput

0.489

High

1258159

TRI52
E3 ubiquitin-protein ligase TRIM52

1

1

High-throughput

0.489

High

1258172

BUD13
BUD13 homolog

1

1

High-throughput

0.489

High

1258138

IQUB
IQ motif and ubiquitin-like domain-containing protein

1

0

High-throughput

0.481

High

1193609

Q49AR9
ANKS1A protein

1

3

High-throughput

0.470

High

1258163

Q96EJ4
PLAC8 protein

1

1

High-throughput

0.470

High

1258227

X5D778
Ankyrin repeat domain 11 isoform A

1

2

High-throughput

0.470

High

928289

ATN1
Atrophin-1

1

1

High-throughput

0.464

High

221861

CHM2A
Charged multivesicular body protein 2a

1

4

Small-scale

0.457

High

1258119

CHM1B
Charged multivesicular body protein 1b

1

7

Small-scale

0.457

High

1258160

CHM4C
Charged multivesicular body protein 4c

1

4

Small-scale

0.457

High

1258165

CHMP6
Charged multivesicular body protein 6

1

5

Small-scale

0.457

High

1258179

CHM4A
Charged multivesicular body protein 4a

1

4

Small-scale

0.457

High

1258186

CHM4B
Charged multivesicular body protein 4b

1

4

Small-scale

0.457

High

1258192

CHM1A
Charged multivesicular body protein 1a

1

7

Small-scale

0.457

High

1258201

CHMP5
Charged multivesicular body protein 5

1

7

Small-scale

0.457

High

1258213

CHM2B
Charged multivesicular body protein 2b

1

8

Small-scale

0.457

High

1258223

CHMP3
Charged multivesicular body protein 3

1

8

Small-scale

0.457

High

1247939

ANR11
Ankyrin repeat domain-containing protein 11

1

1

High-throughput

0.439

High

1258155

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

2

High-throughput

0.439

High

1258199

PLAC8
Placenta-specific gene 8 protein

1

1

High-throughput

0.439

High

174541

TRI66
Tripartite motif-containing protein 66

1

1

High-throughput

0.437

High

289590

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

2

High-throughput

0.437

High

349133

LATS1
Serine/threonine-protein kinase LATS1

1

1

High-throughput

0.437

High

691162

1433T
14-3-3 protein theta

1

9

High-throughput

0.437

High

730709

1433S
14-3-3 protein sigma

1

9

High-throughput

0.437

High

764853

CTNB1
Catenin beta-1

1

1

High-throughput

0.437

High

833300

PERI
Peripherin

1

1

High-throughput

0.437

High

942699

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.437

High

1165458

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

1

High-throughput

0.437

High

1249409

OLFM4
Olfactomedin-4

1

1

High-throughput

0.437

High

1252100

SYNE3
Nesprin-3

1

1

High-throughput

0.437

High

1256495

CE128
Centrosomal protein of 128 kDa

1

1

High-throughput

0.437

High

1258122

PATL1
Protein PAT1 homolog 1

1

1

High-throughput

0.437

High

1258133

NIN
Ninein

1

3

High-throughput

0.437

High

1258142

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

3

High-throughput

0.437

High

1258148

BICD2
Protein bicaudal D homolog 2

1

3

High-throughput

0.437

High

1258149

PARD3
Partitioning defective 3 homolog

1

1

High-throughput

0.437

High

1258166

BICD1
Protein bicaudal D homolog 1

1

3

High-throughput

0.437

High

1258173

LZTS2
Leucine zipper putative tumor suppressor 2

1

2

High-throughput

0.437

High

1258180

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

2

High-throughput

0.437

High

1258191

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

4

High-throughput

0.437

High

1258197

LATS2
Serine/threonine-protein kinase LATS2

1

1

High-throughput

0.437

High

1258203

ZO2
Tight junction protein 2

1

1

High-throughput

0.437

High

1258212

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

3

High-throughput

0.437

High

1258219

R3HD2
R3H domain-containing protein 2

1

1

High-throughput

0.437

High

881997

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.407

High

1258202

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

1

High-throughput

0.407

High

1258220

S27A5
Long-chain fatty acid transport protein 5

1

1

High-throughput

0.407

High

1258215

CLC11
C-type lectin domain family 11 member A

3

0

High-throughput

0.347

High

1258157

PIGT
GPI-anchor transamidase component PIGT

3

0

High-throughput

0.345

High

1115753

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

0

High-throughput

0.330

High

1063796

LG3BP
Galectin-3-binding protein

2

0

High-throughput

0.328

High

1251899

THSD4
Thrombospondin type-1 domain-containing protein 4

2

0

High-throughput

0.328

High

1258130

BBS7
BBSome complex member BBS7

2

0

High-throughput

0.328

High

1258141

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

0

High-throughput

0.328

High

1258169

VPS39
Vam6/Vps39-like protein

2

0

High-throughput

0.328

High

1258181

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.328

High

971689

1433E
14-3-3 protein epsilon

2

0

High-throughput

0.318

High

1258128

VRK3
Serine/threonine-protein kinase VRK3

2

0

High-throughput

0.318

High

1258136

SIR6
NAD-dependent protein deacylase sirtuin-6

2

0

High-throughput

0.318

High

1258217

CARD8
Caspase recruitment domain-containing protein 8

2

0

High-throughput

0.318

High

70303

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

154998

BHE40
Class E basic helix-loop-helix protein 40

2

0

High-throughput

0.316

High

169609

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

0

High-throughput

0.316

High

180322

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

0

High-throughput

0.316

High

210306

PHF1
PHD finger protein 1

2

0

High-throughput

0.316

High

217127

MS18B
Protein Mis18-beta

2

0

High-throughput

0.316

High

288306

GCM2
Chorion-specific transcription factor GCMb

2

0

High-throughput

0.316

High

291823

STK16
Serine/threonine-protein kinase 16

2

0

High-throughput

0.316

High

297004

CCNK
Cyclin-K

2

0

High-throughput

0.316

High

322737

RHBT3
Rho-related BTB domain-containing protein 3

2

0

High-throughput

0.316

High

330213

VENTX
Homeobox protein VENTX

2

0

High-throughput

0.316

High

338344

SC24A
Protein transport protein Sec24A

2

0

High-throughput

0.316

High

351446

TBX6
T-box transcription factor TBX6

2

0

High-throughput

0.316

High

506743

PRR35
Proline-rich protein 35

2

0

High-throughput

0.316

High

574337

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

0

High-throughput

0.316

High

725077

HXC8
Homeobox protein Hox-C8

2

0

High-throughput

0.316

High

733176

OTX1
Homeobox protein OTX1

2

0

High-throughput

0.316

High

750434

CSTF2
Cleavage stimulation factor subunit 2

2

0

High-throughput

0.316

High

775872

HNF1B
Hepatocyte nuclear factor 1-beta

2

0

High-throughput

0.316

High

783716

ZNF76
Zinc finger protein 76

2

0

High-throughput

0.316

High

912936

HNRPF
Heterogeneous nuclear ribonucleoprotein F

2

0

High-throughput

0.316

High

1091222

FOXI1
Forkhead box protein I1

2

0

High-throughput

0.316

High

1150115

TCEA2
Transcription elongation factor A protein 2

2

0

High-throughput

0.316

High

1169070

INSC
Protein inscuteable homolog

2

0

High-throughput

0.316

High

1180149

QRIC1
Transcriptional regulator QRICH1

2

0

High-throughput

0.316

High

1193111

PKHN1
Pleckstrin homology domain-containing family N member 1

2

0

High-throughput

0.316

High

1198243

FND3B
Fibronectin type III domain-containing protein 3B

2

0

High-throughput

0.316

High

1224834

TENS2
Tensin-2

2

0

High-throughput

0.316

High

1231752

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

2

0

High-throughput

0.316

High

1245788

DOK6
Docking protein 6

2

0

High-throughput

0.316

High

1253957

RBPS2
RNA-binding protein with multiple splicing 2

2

0

High-throughput

0.316

High

1258115

MED25
Mediator of RNA polymerase II transcription subunit 25

2

0

High-throughput

0.316

High

1258118

EPMIP
EPM2A-interacting protein 1

2

0

High-throughput

0.316

High

1258121

AP2D
Transcription factor AP-2-delta

2

0

High-throughput

0.316

High

1258123

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.316

High

1258131

CCD13
Coiled-coil domain-containing protein 13

2

0

High-throughput

0.316

High

1258132

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.316

High

1258134

CCD24
Coiled-coil domain-containing protein 24

2

0

High-throughput

0.316

High

1258140

SMYD1
Histone-lysine N-methyltransferase SMYD1

2

0

High-throughput

0.316

High

1258146

LMO3
LIM domain only protein 3

2

0

High-throughput

0.316

High

1258152

SEN15
tRNA-splicing endonuclease subunit Sen15

2

0

High-throughput

0.316

High

1258153

ZCH14
Zinc finger CCHC domain-containing protein 14

2

0

High-throughput

0.316

High

1258158

TET5B
Terminal nucleotidyltransferase 5B

2

0

High-throughput

0.316

High

1258162

FBX17
F-box only protein 17

2

0

High-throughput

0.316

High

1258167

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

0

High-throughput

0.316

High

1258170

TEKT5
Tektin-5

2

0

High-throughput

0.316

High

1258171

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

0

High-throughput

0.316

High

1258174

NUD22
Uridine diphosphate glucose pyrophosphatase NUDT22

2

0

High-throughput

0.316

High

1258175

RAMAC
RNA guanine-N7 methyltransferase activating subunit

2

0

High-throughput

0.316

High

1258182

TOLIP
Toll-interacting protein

2

0

High-throughput

0.316

High

1258183

SHRPN
Sharpin

2

0

High-throughput

0.316

High

1258188

F124B
Protein FAM124B

2

0

High-throughput

0.316

High

1258189

ARMC7
Armadillo repeat-containing protein 7

2

0

High-throughput

0.316

High

1258194

DMRT3
Doublesex- and mab-3-related transcription factor 3

2

0

High-throughput

0.316

High

1258195

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

0

High-throughput

0.316

High

1258225

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

2

0

High-throughput

0.316

High

1258210

PNMA2
Paraneoplastic antigen Ma2

2

0

High-throughput

0.313

High

1226145

CP135
Centrosomal protein of 135 kDa

2

0

High-throughput

0.305

High

252095

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.299

High

1258193

NXT2
NTF2-related export protein 2

1

0

High-throughput

0.299

High

191352

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.279

Low

706183

S10A2
Protein S100-A2

1

0

High-throughput

0.279

Low

997816

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.279

Low

1093257

FLII
Protein flightless-1 homolog

1

0

High-throughput

0.279

Low

1178843

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1207405

HABP4
Intracellular hyaluronan-binding protein 4

1

0

High-throughput

0.279

Low

1258139

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.279

Low

1258143

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.279

Low

1258144

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.279

Low

1258145

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.279

Low

1258161

RMXL1
RNA binding motif protein, X-linked-like-1

1

0

High-throughput

0.279

Low

1258164

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1258185

PDCL3
Phosducin-like protein 3

1

0

High-throughput

0.279

Low

1258190

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.279

Low

1258196

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.279

Low

1258221

CRYL1
Lambda-crystallin homolog

1

0

High-throughput

0.279

Low

1258222

CDIN1
CDAN1-interacting nuclease 1

1

0

High-throughput

0.279

Low

1258226

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.279

Low

385886

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.268

Low

1258120

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.268

Low

1258126

Q86WV8
TSC complex subunit 1

1

0

High-throughput

0.268

Low

1213418

AT7L2
Ataxin-7-like protein 2

1

0

High-throughput

0.251

Low

136105

PLK4
Serine/threonine-protein kinase PLK4

1

0

High-throughput

0.249

Low

176502

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.249

Low

179617

MUSK
Muscle, skeletal receptor tyrosine-protein kinase

1

0

High-throughput

0.249

Low

299256

FLOT1
Flotillin-1

1

0

High-throughput

0.249

Low

331076

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.249

Low

401033

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

440129

LCK
Tyrosine-protein kinase Lck

1

0

High-throughput

0.249

Low

475610

K1C19
Keratin, type I cytoskeletal 19

1

0

High-throughput

0.249

Low

520155

ANDR
Androgen receptor

1

0

High-throughput

0.249

Low

688268

TTP
mRNA decay activator protein ZFP36

1

0

High-throughput

0.249

Low

697930

CALR
Calreticulin

1

0

High-throughput

0.249

Low

710324

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.249

Low

875698

PRC2A
Protein PRRC2A

1

0

High-throughput

0.249

Low

936367

AFAD
Afadin

1

0

High-throughput

0.249

Low

984173

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.249

Low

1034488

TAGL
Transgelin

1

0

Small-scale

0.249

Low

1045432

TF65
Transcription factor p65

1

0

High-throughput

0.249

Low

1107853

SQSTM
Sequestosome-1

1

0

High-throughput

0.249

Low

1149314

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.249

Low

1159713

OCLN
Occludin

1

0

High-throughput

0.249

Low

1178217

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1215676

RC3H1
Roquin-1

1

0

High-throughput

0.249

Low

1226453

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1228975

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.249

Low

1252313

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.249

Low

1254094

ZBT49
Zinc finger and BTB domain-containing protein 49

1

0

High-throughput

0.249

Low

1258117

DET1
DET1 homolog

1

0

High-throughput

0.249

Low

1258127

CCNJL
Cyclin-J-like protein

1

0

High-throughput

0.249

Low

1258150

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

1258151

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.249

Low

1258168

FUBP3
Far upstream element-binding protein 3

1

0

High-throughput

0.249

Low

1258178

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low

1258187

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1258198

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.249

Low

1258200

SPN90
NCK-interacting protein with SH3 domain

1

0

High-throughput

0.249

Low

1258205

HOOK1
Protein Hook homolog 1

1

0

High-throughput

0.249

Low

1258208

ANC2
Anaphase-promoting complex subunit 2

1

0

High-throughput

0.249

Low

1063057

S20A2
Sodium-dependent phosphate transporter 2

1

0

High-throughput

0.232

Low

1258114

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025