Protein: FRMD6
FERM domain-containing protein 6 (Willin)

Gene: FRMD6
Organism: Homo sapiens
Interactions: 85
UniProt ID: Q96NE9

Gene Ontology (top 5):
GO:0003383 - apical constriction
GO:0005737 - cytoplasm
GO:0005856 - cytoskeleton
GO:0005886 - plasma membrane
GO:0008104 - intracellular protein localization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

966760

1433G
14-3-3 protein gamma

7

20

High-throughput

0.748

High

730157

1433B
14-3-3 protein beta/alpha

7

20

High-throughput

0.742

High

691343

1433T
14-3-3 protein theta

5

20

High-throughput

0.709

High

971892

1433E
14-3-3 protein epsilon

5

10

High-throughput

0.703

High

1049677

1433F
14-3-3 protein eta

4

20

High-throughput

0.699

High

827467

MLH1
DNA mismatch repair protein Mlh1

6

3

High-throughput

0.668

High

1115592

ASPP2
Apoptosis-stimulating of p53 protein 2

3

20

High-throughput

0.667

High

1340406

RASF8
Ras association domain-containing protein 8

5

3

High-throughput

0.656

High

990618

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.650

High

1328656

KCD17
BTB/POZ domain-containing protein KCTD17

3

20

High-throughput

0.650

High

422923

A4
Amyloid-beta precursor protein

2

8

High-throughput

0.628

High

1398984

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

1104647

IKZF1
DNA-binding protein Ikaros

3

2

High-throughput

0.616

High

1039114

RASF7
Ras association domain-containing protein 7

2

5

High-throughput

0.611

High

1398974

SYT17
Synaptotagmin-17

2

2

High-throughput

0.606

High

1398977

PAR6B
Partitioning defective 6 homolog beta

2

18

High-throughput

0.606

High

391413

FRIL
Ferritin light chain

2

2

High-throughput

0.601

High

1238104

HMBX1
Homeobox-containing protein 1

1

3

High-throughput

0.573

High

1239650

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

3

High-throughput

0.573

High

1389869

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

4

High-throughput

0.573

High

1398973

LZTS2
Leucine zipper putative tumor suppressor 2

1

18

High-throughput

0.573

High

1398983

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

20

High-throughput

0.573

High

730834

1433S
14-3-3 protein sigma

2

20

High-throughput

0.571

High

1288367

TLK2
Serine/threonine-protein kinase tousled-like 2

2

11

High-throughput

0.553

High

137265

EXOC5
Exocyst complex component 5

1

0

High-throughput

0.549

High

1398979

GO45
Golgin-45

1

0

High-throughput

0.549

High

1398985

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.549

High

1380824

TRI63
E3 ubiquitin-protein ligase TRIM63

1

18

High-throughput

0.541

High

1398978

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.541

High

1398987

T22D4
TSC22 domain family protein 4

1

5

High-throughput

0.541

High

1398980

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

High-throughput

0.523

High

603337

KPCA
Protein kinase C alpha type

1

11

High-throughput

0.515

High

986646

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.515

High

1139806

SETB1
Histone-lysine N-methyltransferase SETDB1

1

4

High-throughput

0.515

High

1347360

LMO3
LIM domain only protein 3

1

8

High-throughput

0.515

High

1371246

KAT5
Histone acetyltransferase KAT5

1

2

High-throughput

0.515

High

886562

CTCF
Transcriptional repressor CTCF

1

3

High-throughput

0.489

High

216519

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

High-throughput

0.486

High

1398972

HTF4
Transcription factor 12

1

1

High-throughput

0.481

High

1398988

WDR7
WD repeat-containing protein 7

1

8

High-throughput

0.481

High

414433

P53
Cellular tumor antigen p53

1

9

High-throughput

0.479

High

845761

MUC18
Cell surface glycoprotein MUC18

1

20

High-throughput

0.479

High

936414

AFAD
Afadin

1

20

High-throughput

0.479

High

975182

ARF6
ADP-ribosylation factor 6

1

8

High-throughput

0.479

High

1045659

TF65
Transcription factor p65

1

11

High-throughput

0.479

High

1398982

XPO7
Exportin-7

1

10

High-throughput

0.479

High

595850

H13
Histone H1.3

1

5

High-throughput

0.470

High

717578

PDIA3
Protein disulfide-isomerase A3

1

7

High-throughput

0.470

High

60204

A2RRE0
WDR7 protein

1

1

High-throughput

0.470

High

1200440

Q53SE7
Germ cell-less homolog 1

1

1

High-throughput

0.470

High

167638

GIPC1
PDZ domain-containing protein GIPC1

1

0

High-throughput

0.458

High

1398986

AP3M1
AP-3 complex subunit mu-1

1

7

High-throughput

0.457

High

75779

B3KXM2
Serine/threonine-protein phosphatase

1

12

High-throughput

0.445

High

239175

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.445

High

259056

DNJA2
DnaJ homolog subfamily A member 2

1

6

High-throughput

0.445

High

531128

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

5

High-throughput

0.445

High

760842

GLYC
Serine hydroxymethyltransferase, cytosolic

1

1

High-throughput

0.445

High

890676

RGS3
Regulator of G-protein signaling 3

1

8

High-throughput

0.445

High

931068

HSP72
Heat shock-related 70 kDa protein 2

1

9

High-throughput

0.445

High

967923

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

13

High-throughput

0.445

High

1233167

ABLM2
Actin-binding LIM protein 2

1

11

High-throughput

0.445

High

1251991

LDH6A
L-lactate dehydrogenase A-like 6A

1

1

High-throughput

0.445

High

1325306

PALS1
Protein PALS1

1

20

High-throughput

0.445

High

1341087

INADL
InaD-like protein

1

18

High-throughput

0.445

High

1366660

SORL
Sortilin-related receptor

1

1

High-throughput

0.445

High

1369616

APBB2
Amyloid beta precursor protein binding family B member 2

1

1

High-throughput

0.445

High

1398975

LRRC1
Leucine-rich repeat-containing protein 1

1

5

High-throughput

0.445

High

1394251

GMCL1
Germ cell-less protein-like 1

1

1

High-throughput

0.439

High

1187538

AR13B
ADP-ribosylation factor-like protein 13B

1

16

High-throughput

0.437

High

1391376

MRAP2
Melanocortin-2 receptor accessory protein 2

1

0

High-throughput

0.426

High

1398981

ADPRS
ADP-ribosylhydrolase ARH3

1

0

High-throughput

0.426

High

126168

AP3B1
AP-3 complex subunit beta-1

1

6

High-throughput

0.407

High

158872

AP3D1
AP-3 complex subunit delta-1

1

9

High-throughput

0.407

High

372878

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.407

High

772336

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

8

High-throughput

0.407

High

928650

PMS1
PMS1 protein homolog 1

1

3

High-throughput

0.407

High

928703

PMS2
Mismatch repair endonuclease PMS2

1

3

High-throughput

0.407

High

1144130

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.407

High

1258546

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

6

High-throughput

0.407

High

1398976

MAK16
Protein MAK16 homolog

4

0

High-throughput

0.364

High

1139026

SNX17
Sorting nexin-17

2

0

High-throughput

0.318

High

1256719

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.316

High

1251490

CX6B2
Cytochrome c oxidase subunit 6B2

1

0

High-throughput

0.299

High

1066107

ZN543
Zinc finger protein 543

1

0

High-throughput

0.279

Low

1010698

DCD
Dermcidin

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025