Protein: TSP50
Probable threonine protease PRSS50 (EC 3.4.25.-) (Cancer/testis antigen 20) (Serine protease 50) (Testis-specific protease-like protein 50)

Gene: TSP50, PRSS50
Organism: Homo sapiens
Interactions: 44
UniProt ID: Q9UI38

Gene Ontology (top 5):
GO:0004252 - serine-type endopeptidase activity
GO:0004298 - threonine-type endopeptidase activity
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

95768

PRS46
Putative serine protease 46

3

16

High-throughput

0.847

High

535653

BIP
Endoplasmic reticulum chaperone BiP

3

11

High-throughput

0.667

High

1207021

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

3

1

High-throughput

0.667

High

1433425

TBB1
Tubulin beta-1 chain

3

20

High-throughput

0.667

High

1459969

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

3

12

High-throughput

0.667

High

1421072

ZY11B
Protein zyg-11 homolog B

3

0

High-throughput

0.638

High

212613

GPAA1
GPI-anchor transamidase component GPAA1

2

2

High-throughput

0.611

High

1433300

TOR3A
Torsin-3A

2

13

High-throughput

0.611

High

1402206

PIGS
GPI-anchor transamidase component PIGS

3

1

High-throughput

0.609

High

1451240

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

3

7

High-throughput

0.609

High

75622

B3KUP4
Probable threonine protease PRSS50

1

15

High-throughput

0.575

High

1091061

FOXF1
Forkhead box protein F1

2

2

High-throughput

0.558

High

1136189

SPCS2
Signal peptidase complex subunit 2

2

3

High-throughput

0.558

High

1380557

PIGT
GPI-anchor transamidase component PIGT

2

1

High-throughput

0.558

High

690135

AVR2A
Activin receptor type-2A

1

4

Small-scale

0.552

High

374994

RASH
GTPase HRas

1

10

High-throughput

0.541

High

376919

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

5

High-throughput

0.541

High

1154471

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.541

High

457760

TBB5
Tubulin beta chain

1

20

High-throughput

0.536

High

755518

ERD22
ER lumen protein-retaining receptor 2

1

1

High-throughput

0.536

High

997178

TBA4A
Tubulin alpha-4A chain

1

16

High-throughput

0.536

High

1098499

DNJC3
DnaJ homolog subfamily C member 3

1

13

High-throughput

0.536

High

1108745

TBB3
Tubulin beta-3 chain

1

20

High-throughput

0.536

High

1235426

ACD10
Acyl-CoA dehydrogenase family member 10

1

6

High-throughput

0.536

High

1258204

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

1

High-throughput

0.536

High

1259557

TBA1A
Tubulin alpha-1A chain

1

18

High-throughput

0.536

High

1389928

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

5

High-throughput

0.536

High

1410630

TBA1C
Tubulin alpha-1C chain

1

19

High-throughput

0.536

High

1437482

RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

1

3

High-throughput

0.536

High

1132461

CASP8
Caspase-8

1

0

High-throughput

0.518

High

1407493

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.518

High

1367528

ESR2
Estrogen receptor beta

1

5

High-throughput

0.494

High

1065826

SLFN5
Schlafen family member 5

1

3

High-throughput

0.489

High

1200291

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

5

High-throughput

0.489

High

1205749

SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

1

2

High-throughput

0.489

High

1233672

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

10

High-throughput

0.489

High

1278480

PLGT3
Protein O-glucosyltransferase 3

1

6

High-throughput

0.489

High

1349173

S2540
Mitochondrial glutathione transporter SLC25A40

1

17

High-throughput

0.489

High

1398926

SFXN2
Sideroflexin-2

1

7

High-throughput

0.489

High

1460227

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

High-throughput

0.489

High

1366374

GPI8
GPI-anchor transamidase

1

2

High-throughput

0.479

High

1433187

PIGU
GPI-anchor transamidase component PIGU

1

1

High-throughput

0.437

High

1450718

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

3

High-throughput

0.437

High

653650

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025