Protein: SPCS2
Signal peptidase complex subunit 2 (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit)

Gene: SPCS2
Organism: Homo sapiens
Interactions: 152
UniProt ID: Q15005

Gene Ontology (top 5):
GO:0005787 - signal peptidase complex
GO:0005789 - endoplasmic reticulum membrane
GO:0006465 - signal peptide processing
GO:0045047 - protein targeting to ER

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1136160

SC11C
Signal peptidase complex catalytic subunit SEC11C

4

3

High-throughput

0.892

High

994914

SC11A
Signal peptidase complex catalytic subunit SEC11A

2

3

High-throughput

0.776

High

1136198

SPCS1
Signal peptidase complex subunit 1

2

0

High-throughput

0.748

High

1136152

TECT2
Tectonic-2

3

1

High-throughput

0.609

High

956054

SPCS3
Signal peptidase complex subunit 3

2

1

High-throughput

0.601

High

698667

CALX
Calnexin

2

0

High-throughput

0.585

High

1136118

TGO1
Transport and Golgi organization protein 1 homolog

2

0

High-throughput

0.585

High

283685

GPC4
Glypican-4

2

2

High-throughput

0.574

High

762325

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

2

2

High-throughput

0.574

High

1136189

TSP50
Probable threonine protease PRSS50

2

3

High-throughput

0.558

High

363304

EGFR
Epidermal growth factor receptor

2

0

Small-scale

0.551

High

220499

RNF13
E3 ubiquitin-protein ligase RNF13

1

3

High-throughput

0.536

High

1136191

AMFR
E3 ubiquitin-protein ligase AMFR

1

1

High-throughput

0.536

High

535072

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.513

High

595050

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

0

High-throughput

0.513

High

1136148

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.513

High

1136150

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1136168

LMA1L
Protein ERGIC-53-like

1

0

High-throughput

0.513

High

1136182

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.513

High

664045

PRTN3
Myeloblastin

1

2

High-throughput

0.489

High

729057

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

1

High-throughput

0.489

High

1005526

GPC5
Glypican-5 [Cleaved into: Secreted glypican-5]

1

2

High-throughput

0.489

High

373934

RASN
GTPase NRas

1

1

High-throughput

0.479

High

375529

RASK
GTPase KRas

1

1

High-throughput

0.479

High

466257

RHOC
Rho-related GTP-binding protein RhoC

1

3

High-throughput

0.479

High

581056

RAC2
Ras-related C3 botulinum toxin substrate 2

1

3

High-throughput

0.479

High

962060

RHOA
Transforming protein RhoA

1

3

High-throughput

0.479

High

1015445

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.479

High

1136131

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

3

High-throughput

0.479

High

1136187

CLN8
Protein CLN8

1

0

Small-scale

0.460

High

173920

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

241711

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

417443

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

418136

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

847536

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

903913

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

951155

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

1042621

UPAR
Urokinase plasminogen activator surface receptor

1

0

High-throughput

0.458

High

1058420

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

1136113

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

1136114

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.458

High

1136117

MKS3
Meckelin

1

0

High-throughput

0.458

High

1136126

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1136139

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

1136149

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.458

High

1136151

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1136156

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1136158

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1136162

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1136164

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

1136179

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1136185

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

540460

LAMP1
Lysosome-associated membrane glycoprotein 1

1

1

High-throughput

0.437

High

634450

LMNB1
Lamin-B1

1

1

High-throughput

0.437

High

1136123

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1136127

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1136130

TM11B
Transmembrane protease serine 11B

1

1

High-throughput

0.437

High

1136135

GOLI
E3 ubiquitin-protein ligase RNF130

1

4

High-throughput

0.437

High

1136141

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.437

High

1136175

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.437

High

1136181

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.437

High

1136193

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.437

High

1136119

S35D3
Solute carrier family 35 member D3

1

0

High-throughput

0.426

High

1136120

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1136124

S27A4
Long-chain fatty acid transport protein 4

1

0

High-throughput

0.426

High

1136144

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

0

High-throughput

0.426

High

1136153

BT2A3
Putative butyrophilin subfamily 2 member A3

1

1

High-throughput

0.407

High

880009

DNSL1
Deoxyribonuclease-1-like 1

4

0

High-throughput

0.360

High

1136121

PVRIG
Transmembrane protein PVRIG

3

0

High-throughput

0.347

High

1136157

TM2D3
TM2 domain-containing protein 3

3

0

High-throughput

0.347

High

1136138

FXL14
F-box/LRR-repeat protein 14

3

0

High-throughput

0.345

High

1136190

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

3

0

High-throughput

0.345

High

338689

VNN2
Pantetheine hydrolase VNN2

2

0

High-throughput

0.328

High

426024

PPBT
Alkaline phosphatase, tissue-nonspecific isozyme

2

0

High-throughput

0.328

High

1136186

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

2

0

High-throughput

0.328

High

967306

TSN5
Tetraspanin-5

2

0

High-throughput

0.318

High

1005539

GBRE
Gamma-aminobutyric acid receptor subunit epsilon

2

0

High-throughput

0.318

High

1136172

AT132
Polyamine-transporting ATPase 13A2

1

0

Small-scale

0.282

High

130103

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.279

Low

608270

EGLN
Endoglin

1

0

High-throughput

0.279

Low

914260

EFNA4
Ephrin-A4

1

0

High-throughput

0.279

Low

1093108

STK4
Serine/threonine-protein kinase 4

1

0

High-throughput

0.279

Low

1136115

AMHR2
Anti-Muellerian hormone type-2 receptor

1

0

High-throughput

0.279

Low

1136125

ARSK
Arylsulfatase K

1

0

High-throughput

0.279

Low

1136136

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1136143

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

High-throughput

0.279

Low

1136161

RTN4R
Reticulon-4 receptor

1

0

High-throughput

0.279

Low

1136165

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

1136170

TREM1
Triggering receptor expressed on myeloid cells 1

1

0

High-throughput

0.279

Low

1136171

NRN1
Neuritin

1

0

High-throughput

0.279

Low

1136174

FBX6
F-box only protein 6

1

0

High-throughput

0.279

Low

1136176

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.279

Low

1136195

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.279

Low

1136199

WNT6
Protein Wnt-6

1

0

High-throughput

0.279

Low

125462

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

170143

AURKA
Aurora kinase A

1

0

High-throughput

0.249

Low

178269

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.249

Low

218194

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

293702

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

370197

CYTN
Cystatin-SN

1

0

Small-scale

0.249

Low

413851

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

429910

JUN
Transcription factor Jun

1

0

High-throughput

0.249

Low

588723

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

695486

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768221

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

820643

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.249

Low

830755

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

832365

OPRD
Delta-type opioid receptor

1

0

Small-scale

0.249

Low

854854

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.249

Low

888075

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

900821

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.249

Low

979678

H4
Histone H4

1

0

High-throughput

0.249

Low

1004579

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1135678

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1136116

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

1136128

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1136129

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.249

Low

1136132

LBN
Limbin

1

0

High-throughput

0.249

Low

1136134

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

1136137

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

1136140

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.249

Low

1136142

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

1136146

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

0

High-throughput

0.249

Low

1136147

TNR14
Tumor necrosis factor receptor superfamily member 14

1

0

High-throughput

0.249

Low

1136154

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1136163

TOLIP
Toll-interacting protein

1

0

High-throughput

0.249

Low

1136167

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.249

Low

1136173

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1136177

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1136178

DDX56
Probable ATP-dependent RNA helicase DDX56

1

0

High-throughput

0.249

Low

1136183

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

1136184

SIRPG
Signal-regulatory protein gamma

1

0

High-throughput

0.249

Low

1136188

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1136192

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.249

Low

1136196

TLN1
Talin-1

1

0

High-throughput

0.249

Low

1136197

TRI17
E3 ubiquitin-protein ligase TRIM17

1

0

Small-scale

0.249

Low

444981

S10A9
Protein S100-A9

1

0

Small-scale

0.238

Low

1136155

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.238

Low

1136180

STMN3
Stathmin-3

1

0

High-throughput

0.238

Low

339043

GTR10
Solute carrier family 2, facilitated glucose transporter member 10

1

0

High-throughput

0.232

Low

529814

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.232

Low

841176

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.232

Low

870443

SC6A9
Sodium- and chloride-dependent glycine transporter 1

1

0

High-throughput

0.232

Low

1098704

NDK3
Nucleoside diphosphate kinase 3

1

0

High-throughput

0.232

Low

1131532

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.232

Low

1136122

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

1136133

UN93A
Protein unc-93 homolog A

1

0

High-throughput

0.232

Low

1136145

SSMM1
Serine-rich single-pass membrane protein 1

1

0

High-throughput

0.232

Low

1136159

S12A9
Solute carrier family 12 member 9

1

0

High-throughput

0.232

Low

1136166

PACC1
Proton-activated chloride channel

1

0

High-throughput

0.232

Low

1136169

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.232

Low

1136194

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025