Protein: PIGU
GPI-anchor transamidase component PIGU (Cell division cycle protein 91-like 1) (Protein CDC91-like 1) (GPI transamidase component PIG-U) (Phosphatidylinositol glycan anchor biosynthesis class U protein)

Gene: PIGU
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q9H490

Gene Ontology (top 5):
GO:0003923 - GPI-anchor transamidase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006506 - GPI anchor biosynthetic process
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1380533

PIGT
GPI-anchor transamidase component PIGT

3

0

High-throughput

0.811

High

1402193

PIGS
GPI-anchor transamidase component PIGS

2

1

Small-scale

0.776

High

1366364

GPI8
GPI-anchor transamidase

4

1

Small-scale

0.691

High

332706

LYPD3
Ly6/PLAUR domain-containing protein 3

3

0

High-throughput

0.638

High

1399296

NECT4
Nectin-4

3

0

High-throughput

0.638

High

1350069

SPP2B
Signal peptide peptidase-like 2B

2

3

High-throughput

0.628

High

1433185

CLC5A
C-type lectin domain family 5 member A

2

2

High-throughput

0.611

High

338710

VNN2
Pantetheine hydrolase VNN2

2

0

High-throughput

0.602

High

1366232

LPAR1
Lysophosphatidic acid receptor 1

2

0

High-throughput

0.585

High

1239048

NIPA3
Magnesium transporter NIPA3

2

0

High-throughput

0.576

High

212606

GPAA1
GPI-anchor transamidase component GPAA1

1

1

High-throughput

0.575

High

417754

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

0

High-throughput

0.559

High

936122

PAR2
Proteinase-activated receptor 2

1

4

High-throughput

0.541

High

141868

ACKR2
Atypical chemokine receptor 2

1

2

High-throughput

0.536

High

166044

FFAR1
Free fatty acid receptor 1

1

5

High-throughput

0.536

High

349568

TSN15
Tetraspanin-15

1

1

High-throughput

0.536

High

669210

EDNRA
Endothelin-1 receptor

1

1

High-throughput

0.536

High

688683

NKG2C
NKG2-C type II integral membrane protein

1

2

High-throughput

0.536

High

733074

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

1

High-throughput

0.536

High

833870

P2RY2
P2Y purinoceptor 2

1

4

High-throughput

0.536

High

868019

GLR
Glucagon receptor

1

1

High-throughput

0.536

High

1101661

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

4

High-throughput

0.536

High

1291894

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

4

High-throughput

0.536

High

1390941

TSN17
Tetraspanin-17

1

1

High-throughput

0.536

High

1433182

GPR35
G-protein coupled receptor 35

1

3

High-throughput

0.536

High

1433189

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.536

High

226366

SNG1
Synaptogyrin-1

1

0

High-throughput

0.513

High

260958

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.513

High

295767

AP1G2
AP-1 complex subunit gamma-like 2

1

0

High-throughput

0.513

High

333200

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

0

High-throughput

0.513

High

336577

PIGN
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.513

High

406984

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.513

High

488081

IFI6
Interferon alpha-inducible protein 6

1

0

High-throughput

0.513

High

690382

STOM
Stomatin

1

0

High-throughput

0.513

High

771817

SCN4A
Sodium channel protein type 4 subunit alpha

1

0

High-throughput

0.513

High

937598

CAD13
Cadherin-13

1

0

High-throughput

0.513

High

1086103

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.513

High

1160931

PRSS8
Prostasin

1

0

High-throughput

0.513

High

1208739

RTP2
Receptor-transporting protein 2

1

0

High-throughput

0.513

High

1372161

NAR4
Ecto-ADP-ribosyltransferase 4

1

0

High-throughput

0.513

High

1382193

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1388189

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.513

High

1393080

CREL1
Protein disulfide isomerase CRELD1

1

0

High-throughput

0.513

High

1428154

YIPF3
Protein YIPF3

1

0

High-throughput

0.513

High

1429178

ACH10
Neuronal acetylcholine receptor subunit alpha-10

1

0

High-throughput

0.513

High

1429280

S22A4
Solute carrier family 22 member 4

1

0

High-throughput

0.513

High

1431937

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

0

High-throughput

0.513

High

1433183

GP173
Probable G-protein coupled receptor 173

1

0

High-throughput

0.513

High

1433193

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.513

High

374193

RASN
GTPase NRas

1

1

High-throughput

0.479

High

375949

RASK
GTPase KRas

1

1

High-throughput

0.479

High

404416

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

466458

RHOC
Rho-related GTP-binding protein RhoC

1

3

High-throughput

0.479

High

581286

RAC2
Ras-related C3 botulinum toxin substrate 2

1

3

High-throughput

0.479

High

720698

AGTR1
Type-1 angiotensin II receptor

1

2

High-throughput

0.479

High

951424

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

962476

RHOA
Transforming protein RhoA

1

3

High-throughput

0.479

High

1015782

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.479

High

1381517

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.479

High

1431245

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.479

High

1433190

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

1

High-throughput

0.479

High

48790

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.458

High

218770

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

418435

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

639349

SCF
Kit ligand

1

0

High-throughput

0.458

High

658535

GLRA2
Glycine receptor subunit alpha-2

1

0

High-throughput

0.458

High

714425

PML
Protein PML

1

0

High-throughput

0.458

High

820747

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.458

High

847689

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

895055

EMD
Emerin

1

0

High-throughput

0.458

High

901569

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

904120

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

1036250

NRG1
Pro-neuregulin-1, membrane-bound isoform

1

0

High-throughput

0.458

High

1125660

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1163419

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

1273281

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.458

High

1322986

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.458

High

1404207

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1408569

G3ST1
Galactosylceramide sulfotransferase

1

0

High-throughput

0.458

High

1431744

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

1433180

FNDC4
Fibronectin type III domain-containing protein 4

1

0

High-throughput

0.458

High

1433181

RN121
E3 ubiquitin ligase RNF121

1

0

Small-scale

0.458

High

1433191

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

0

High-throughput

0.458

High

1433192

DJC16
DnaJ homolog subfamily C member 16

1

0

High-throughput

0.458

High

886134

CXCR3
C-X-C chemokine receptor type 3

1

3

High-throughput

0.445

High

1238817

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1367264

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

1392464

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1433187

TSP50
Probable threonine protease PRSS50

1

1

High-throughput

0.437

High

256151

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

564364

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

1236316

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

1313837

S15A3
Solute carrier family 15 member 3

1

4

High-throughput

0.407

High

1329441

KASH5
Protein KASH5

2

0

High-throughput

0.316

High

1091906

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.279

Low

1433188

FBX2
F-box only protein 2

1

0

High-throughput

0.279

Low

1008881

RED1
Double-stranded RNA-specific editase 1

1

0

High-throughput

0.249

Low

1162549

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

1255524

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1293149

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1293666

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

1333997

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.249

Low

1394653

TXD15
Thioredoxin domain-containing protein 15

1

0

High-throughput

0.249

Low

1433184

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1433186

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025