Protein: PIGS
GPI-anchor transamidase component PIGS (Phosphatidylinositol-glycan biosynthesis class S protein)

Gene: PIGS
Organism: Homo sapiens
Interactions: 153
UniProt ID: Q96S52

Gene Ontology (top 5):
GO:0005789 - endoplasmic reticulum membrane
GO:0006506 - GPI anchor biosynthetic process
GO:0016020 - membrane
GO:0016255 - attachment of GPI anchor to protein
GO:0042765 - GPI-anchor transamidase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1380522

PIGT
GPI-anchor transamidase component PIGT

6

2

Small-scale

0.945

High

1366360

GPI8
GPI-anchor transamidase

4

2

Small-scale

0.881

High

1402193

PIGU
GPI-anchor transamidase component PIGU

2

1

Small-scale

0.776

High

212598

GPAA1
GPI-anchor transamidase component GPAA1

5

1

Small-scale

0.700

High

1402204

VAPA
Vesicle-associated membrane protein-associated protein A

2

2

High-throughput

0.611

High

1402206

TSP50
Probable threonine protease PRSS50

3

1

High-throughput

0.609

High

333150

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

2

High-throughput

0.601

High

1277363

NT2NA
Notch homolog 2 N-terminal-like protein A

2

1

High-throughput

0.578

High

1086087

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.576

High

1273274

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

2

0

High-throughput

0.576

High

1329300

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

2

0

High-throughput

0.576

High

1350044

SPP2B
Signal peptide peptidase-like 2B

2

0

High-throughput

0.576

High

950870

KR109
Keratin-associated protein 10-9

2

4

High-throughput

0.553

High

1307438

KRA13
Keratin-associated protein 1-3

2

6

High-throughput

0.553

High

1402188

KRA92
Keratin-associated protein 9-2

2

6

High-throughput

0.553

High

1402207

FBX2
F-box only protein 2

2

1

High-throughput

0.549

High

699032

CALX
Calnexin

1

1

High-throughput

0.536

High

1402197

ENTP7
Ectonucleoside triphosphate diphosphohydrolase 7

1

1

High-throughput

0.536

High

1402209

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

1

High-throughput

0.536

High

1402198

FBX6
F-box only protein 6

2

1

High-throughput

0.533

High

950634

KR108
Keratin-associated protein 10-8

1

6

High-throughput

0.523

High

178978

SCAM2
Secretory carrier-associated membrane protein 2

1

0

High-throughput

0.513

High

259061

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.513

High

295762

AP1G2
AP-1 complex subunit gamma-like 2

1

0

High-throughput

0.513

High

344488

STR3N
STARD3 N-terminal-like protein

1

0

High-throughput

0.513

High

470331

NEP
Neprilysin

1

0

High-throughput

0.513

High

483844

CD7
T-cell antigen CD7

1

0

High-throughput

0.513

High

483954

HMOX1
Heme oxygenase 1

1

0

High-throughput

0.513

High

560060

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.513

High

777001

PPM1A
Protein phosphatase 1A

1

0

High-throughput

0.513

High

888967

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.513

High

1358704

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

1

0

High-throughput

0.513

High

1364138

TM131
Transmembrane protein 131

1

0

High-throughput

0.513

High

1380473

YIPF5
Protein YIPF5

1

0

High-throughput

0.513

High

1382162

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1402190

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

1402192

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

1402195

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

349541

TSN15
Tetraspanin-15

1

2

High-throughput

0.489

High

618414

TSN8
Tetraspanin-8

1

2

High-throughput

0.489

High

967345

TSN5
Tetraspanin-5

1

2

High-throughput

0.489

High

1066005

VAC14
Protein VAC14 homolog

1

1

High-throughput

0.489

High

1242905

S39A4
Zinc transporter ZIP4

1

1

High-throughput

0.489

High

1322777

CNTRB
Centrobin

1

1

High-throughput

0.489

High

1402199

GP173
Probable G-protein coupled receptor 173

1

1

High-throughput

0.489

High

1402203

GPC5B
G-protein coupled receptor family C group 5 member B

1

1

High-throughput

0.489

High

581244

RAC2
Ras-related C3 botulinum toxin substrate 2

1

2

High-throughput

0.479

High

869655

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

2

Small-scale

0.479

High

955502

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.479

High

962406

RHOA
Transforming protein RhoA

1

3

High-throughput

0.479

High

1252188

SYNE3
Nesprin-3

1

1

High-throughput

0.479

High

1294238

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.479

High

1334518

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

1351952

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.479

High

1396531

CALR3
Calreticulin-3

1

1

High-throughput

0.479

High

517086

NT2NC
Notch homolog 2 N-terminal-like protein C

1

1

High-throughput

0.470

High

1402189

KRA24
Keratin-associated protein 2-4

1

6

High-throughput

0.470

High

48751

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.458

High

242664

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

773961

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.458

High

951368

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

1140289

ACAP2
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

1

0

High-throughput

0.458

High

1163404

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

1248529

KIRR2
Kin of IRRE-like protein 2

1

0

High-throughput

0.458

High

1249137

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1383022

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1385228

PLD4
5'-3' exonuclease PLD4

1

0

High-throughput

0.458

High

1402186

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

104212

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.445

High

870402

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

2

High-throughput

0.445

High

1139542

S39AE
Metal cation symporter ZIP14

1

1

High-throughput

0.445

High

1402191

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

2

High-throughput

0.445

High

505372

KRA23
Keratin-associated protein 2-3

1

6

High-throughput

0.439

High

949970

KR103
Keratin-associated protein 10-3

1

6

High-throughput

0.439

High

126756

RHOD
Rho-related GTP-binding protein RhoD

1

4

High-throughput

0.437

High

589470

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

1096793

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.437

High

1238788

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1313806

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1392435

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1402196

RHOF
Rho-related GTP-binding protein RhoF

1

4

High-throughput

0.437

High

256115

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

380577

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

0

High-throughput

0.426

High

564253

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

1236283

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

1242204

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.426

High

1335683

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.426

High

1336028

CTL5
Choline transporter-like protein 5

1

0

High-throughput

0.426

High

1357825

S35F5
Solute carrier family 35 member F5

1

0

High-throughput

0.426

High

1389663

MFSD3
Major facilitator superfamily domain-containing protein 3

1

0

High-throughput

0.426

High

1402202

SCN3B
Sodium channel regulatory subunit beta-3

1

0

High-throughput

0.426

High

303274

S22A5
Organic cation/carnitine transporter 2

1

1

High-throughput

0.407

High

886122

CXCR3
C-X-C chemokine receptor type 3

1

1

High-throughput

0.407

High

907106

CCR9
C-C chemokine receptor type 9

1

1

High-throughput

0.407

High

1308946

S22A9
Organic anion transporter 7

1

1

High-throughput

0.407

High

1383442

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

1

High-throughput

0.407

High

338706

VNN2
Pantetheine hydrolase VNN2

2

0

High-throughput

0.328

High

332697

LYPD3
Ly6/PLAUR domain-containing protein 3

2

0

High-throughput

0.318

High

1151628

TRIP6
Thyroid receptor-interacting protein 6

2

0

High-throughput

0.316

High

1186532

KR192
Keratin-associated protein 19-2

2

0

High-throughput

0.316

High

835364

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

0

High-throughput

0.313

High

1185894

TMM95
Sperm-egg fusion protein TMEM95

2

0

High-throughput

0.313

High

1366191

LPAR1
Lysophosphatidic acid receptor 1

2

0

High-throughput

0.313

High

1230217

K1C40
Keratin, type I cytoskeletal 40

1

0

High-throughput

0.299

High

219352

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.279

Low

261255

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.279

Low

286040

SF3B1
Splicing factor 3B subunit 1

1

0

High-throughput

0.279

Low

298437

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.279

Low

406981

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.279

Low

506896

CFC1
Cryptic protein

1

0

High-throughput

0.279

Low

563029

MYH6
Myosin-6

1

0

High-throughput

0.279

Low

575695

GPIX
Platelet glycoprotein IX

1

0

High-throughput

0.279

Low

724703

MK04
Mitogen-activated protein kinase 4

1

0

High-throughput

0.279

Low

1085953

HYAL1
Hyaluronidase-1

1

0

High-throughput

0.279

Low

1148641

SF3A2
Splicing factor 3A subunit 2

1

0

High-throughput

0.279

Low

1181229

CO032
Uncharacterized protein C15orf32

1

0

High-throughput

0.279

Low

1310332

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1313740

MILK2
MICAL-like protein 2

1

0

High-throughput

0.279

Low

1372159

NAR4
Ecto-ADP-ribosyltransferase 4

1

0

High-throughput

0.279

Low

1394471

ATPMK
ATP synthase F(0) complex subunit k, mitochondrial

1

0

High-throughput

0.279

Low

1402187

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.279

Low

1402208

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

0

High-throughput

0.279

Low

1186795

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low

604

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.251

Low

1279405

CPEB2
Cytoplasmic polyadenylation element-binding protein 2

1

0

Small-scale

0.251

Low

218657

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

506646

GPHRB
Golgi pH regulator B

1

0

High-throughput

0.249

Low

566808

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.249

Low

680737

CATS
Cathepsin S

1

0

High-throughput

0.249

Low

696278

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

702665

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

High-throughput

0.249

Low

768954

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

901509

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.249

Low

1005001

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1126156

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1162506

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

1163503

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.249

Low

1229637

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1248831

ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6

1

0

High-throughput

0.249

Low

1255166

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1312582

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

1367079

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

1402194

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1402200

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

1402201

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1402205

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

222318

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.232

Low

704062

5HT1E
5-hydroxytryptamine receptor 1E

1

0

High-throughput

0.232

Low

1246105

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

0

High-throughput

0.232

Low

1337920

ZNT7
Zinc transporter 7

1

0

High-throughput

0.232

Low

1355919

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

0

High-throughput

0.232

Low

1389564

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low

1401536

S26A8
Testis anion transporter 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025