Protein: GPI8
GPI-anchor transamidase (EC 2.6.1.-) (GPI-anchor transamidase component PIGK, catalytic subunit) (GPI8 homolog) (hGPI8) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K)

Gene: GPI8, PIGK
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q92643

Gene Ontology (top 5):
GO:0003923 - GPI-anchor transamidase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0006506 - GPI anchor biosynthetic process
GO:0006508 - proteolysis
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1366353

PIGT
GPI-anchor transamidase component PIGT

7

2

Small-scale

0.964

High

212592

GPAA1
GPI-anchor transamidase component GPAA1

8

1

Small-scale

0.962

High

1366360

PIGS
GPI-anchor transamidase component PIGS

4

2

Small-scale

0.881

High

1366364

PIGU
GPI-anchor transamidase component PIGU

4

1

Small-scale

0.691

High

333124

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

1

High-throughput

0.628

High

1366365

CST9L
Cystatin-9-like

1

3

High-throughput

0.618

High

698965

CALX
Calnexin

2

2

Small-scale

0.611

High

242466

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

396632

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

1366363

KLK15
Kallikrein-15

1

2

High-throughput

0.536

High

1366371

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

1366375

FBX2
F-box only protein 2

1

3

High-throughput

0.536

High

1313776

S15A3
Solute carrier family 15 member 3

2

1

High-throughput

0.521

High

130192

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.513

High

158276

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

316543

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.513

High

535365

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.513

High

888947

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.513

High

1083519

BST2
Bone marrow stromal antigen 2

1

0

High-throughput

0.513

High

1273260

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.513

High

1366355

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1366362

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

1366367

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

647388

IDS
Iduronate 2-sulfatase

1

1

High-throughput

0.489

High

1366354

T106A
Transmembrane protein 106A

1

1

High-throughput

0.489

High

404285

GCR
Glucocorticoid receptor

1

2

High-throughput

0.479

High

1308177

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

1366357

PLD4
5'-3' exonuclease PLD4

1

1

High-throughput

0.479

High

1366359

CALR3
Calreticulin-3

1

2

High-throughput

0.479

High

1366369

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

1366374

TSP50
Probable threonine protease PRSS50

1

2

High-throughput

0.479

High

417644

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

962338

RHOA
Transforming protein RhoA

1

0

High-throughput

0.458

High

998622

H31
Histone H3.1

1

0

High-throughput

0.458

High

1252163

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

1330335

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

1366356

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

104195

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.445

High

351239

MOT3
Monocarboxylate transporter 3

1

2

High-throughput

0.445

High

869636

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

1

High-throughput

0.445

High

870395

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

1

High-throughput

0.445

High

1335655

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.445

High

218568

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

1254883

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1366352

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

1366366

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1366368

RHOF
Rho-related GTP-binding protein RhoF

1

1

High-throughput

0.437

High

1366370

T106B
Transmembrane protein 106B

1

1

High-throughput

0.437

High

256102

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

1236253

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

1242186

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.426

High

1336024

CTL5
Choline transporter-like protein 5

1

0

High-throughput

0.426

High

1246096

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

2

High-throughput

0.407

High

1363778

YLAT2
Y+L amino acid transporter 2

1

1

High-throughput

0.407

High

332686

LYPD3
Ly6/PLAUR domain-containing protein 3

2

0

High-throughput

0.318

High

426121

PPB1
Alkaline phosphatase, placental type

2

0

Small-scale

0.310

High

191457

SIA8E
Alpha-2,8-sialyltransferase 8E

1

0

High-throughput

0.279

Low

349515

TSN15
Tetraspanin-15

1

0

High-throughput

0.279

Low

406978

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.279

Low

567935

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.279

Low

575686

GPIX
Platelet glycoprotein IX

1

0

High-throughput

0.279

Low

603322

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.279

Low

648212

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.279

Low

1363116

CLC2B
C-type lectin domain family 2 member B

1

0

High-throughput

0.279

Low

1366153

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.279

Low

1366358

CPNE2
Copine-2

1

0

High-throughput

0.279

Low

1366372

P2RX2
P2X purinoceptor 2

1

0

High-throughput

0.279

Low

294110

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

331200

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.249

Low

401233

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

551182

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.249

Low

566780

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.249

Low

589304

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

696095

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768791

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

901448

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.249

Low

1004912

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1100183

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

1126145

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1178285

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1238761

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

1312566

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

1324155

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

1366361

ULBP2
UL16-binding protein 2

1

0

Small-scale

0.249

Low

1366373

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1366376

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

0

High-throughput

0.249

Low

222311

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.232

Low

1202108

HS904
Putative heat shock protein HSP 90-alpha A4

1

0

High-throughput

0.232

Low

1242886

S39A4
Zinc transporter ZIP4

1

0

High-throughput

0.232

Low

1337891

ZNT7
Zinc transporter 7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025