Protein: PPR18
Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18)

Gene: PPR18, PPP1R18
Organism: Homo sapiens
Interactions: 142
UniProt ID: Q6NYC8

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005737 - cytoplasm
GO:0005856 - cytoskeleton
GO:0019902 - phosphatase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

967805

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

8

13

Small-scale

0.753

High

786672

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

9

13

Small-scale

0.752

High

572030

TRI27
Zinc finger protein RFP

4

5

High-throughput

0.703

High

1239740

CARD9
Caspase recruitment domain-containing protein 9

4

7

High-throughput

0.698

High

618049

K1C15
Keratin, type I cytoskeletal 15

3

8

High-throughput

0.675

High

1145990

K1H1
Keratin, type I cuticular Ha1

3

11

High-throughput

0.675

High

1205827

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

15

High-throughput

0.675

High

1228664

C102B
Coiled-coil domain-containing protein 102B

3

6

High-throughput

0.675

High

1239736

TRI54
Tripartite motif-containing protein 54

3

16

High-throughput

0.675

High

1239747

HOME3
Homer protein homolog 3

3

4

High-throughput

0.675

High

1239755

TRIM1
Probable E3 ubiquitin-protein ligase MID2

3

20

High-throughput

0.675

High

442366

GELS
Gelsolin

3

1

High-throughput

0.667

High

968346

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

3

13

High-throughput

0.667

High

396331

ESR1
Estrogen receptor

3

20

High-throughput

0.650

High

606126

DESM
Desmin

4

17

High-throughput

0.637

High

1095673

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

2

12

Small-scale

0.631

High

51434

FSD2
Fibronectin type III and SPRY domain-containing protein 2

3

17

High-throughput

0.616

High

286671

STX11
Syntaxin-11

3

1

High-throughput

0.616

High

1063347

GOGA2
Golgin subfamily A member 2

3

14

High-throughput

0.616

High

1239712

VPS52
Vacuolar protein sorting-associated protein 52 homolog

3

1

High-throughput

0.616

High

1239714

KASH5
Protein KASH5

3

8

High-throughput

0.616

High

944819

PCBP3
Poly(rC)-binding protein 3

2

5

High-throughput

0.611

High

1217077

RAIN
Ras-interacting protein 1

3

8

High-throughput

0.609

High

64540

CC88B
Coiled-coil domain-containing protein 88B

2

10

High-throughput

0.606

High

250272

VINEX
Vinexin

2

20

High-throughput

0.606

High

300388

KRT34
Keratin, type I cuticular Ha4

2

11

High-throughput

0.606

High

474753

VIME
Vimentin

2

17

High-throughput

0.606

High

476340

K1C16
Keratin, type I cytoskeletal 16

2

10

High-throughput

0.606

High

570461

GFAP
Glial fibrillary acidic protein

2

17

High-throughput

0.606

High

703623

MK01
Mitogen-activated protein kinase 1

2

2

High-throughput

0.606

High

833294

PERI
Peripherin

2

17

High-throughput

0.606

High

928193

HAP1
Huntingtin-associated protein 1

2

6

High-throughput

0.606

High

1127652

KT33B
Keratin, type I cuticular Ha3-II

2

11

High-throughput

0.606

High

1239704

K1C27
Keratin, type I cytoskeletal 27

2

8

High-throughput

0.606

High

1239708

DZIP1
Cilium assembly protein DZIP1

2

9

High-throughput

0.606

High

1239717

BICD2
Protein bicaudal D homolog 2

2

15

High-throughput

0.606

High

1239722

GTPB3
5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial

2

2

High-throughput

0.606

High

1239726

HOOK2
Protein Hook homolog 2

2

8

High-throughput

0.606

High

1239730

ASPP1
Apoptosis-stimulating of p53 protein 1

2

10

High-throughput

0.606

High

1239734

TRI62
E3 ubiquitin-protein ligase TRIM62

2

4

High-throughput

0.606

High

1239745

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

2

7

High-throughput

0.606

High

1239751

ZRAN1
Ubiquitin thioesterase ZRANB1

2

8

High-throughput

0.606

High

1239758

LZTS1
Leucine zipper putative tumor suppressor 1

2

14

High-throughput

0.606

High

1239762

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

2

13

High-throughput

0.606

High

1239749

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.606

High

1239743

ECT2
Protein ECT2

2

9

High-throughput

0.584

High

1239746

ANLN
Anillin

2

4

High-throughput

0.584

High

1239707

CDR2L
Cerebellar degeneration-related protein 2-like

2

0

High-throughput

0.580

High

1239711

ABRA
Actin-binding Rho-activating protein

2

0

High-throughput

0.580

High

1239756

IKZF3
Zinc finger protein Aiolos

2

0

High-throughput

0.580

High

1239729

CC136
Coiled-coil domain-containing protein 136

2

10

High-throughput

0.578

High

451182

NFL
Neurofilament light polypeptide

1

18

High-throughput

0.573

High

475604

K1C19
Keratin, type I cytoskeletal 19

1

10

High-throughput

0.573

High

783301

TRI23
E3 ubiquitin-protein ligase TRIM23

1

1

High-throughput

0.573

High

1090721

TRAF2
TNF receptor-associated factor 2

1

2

High-throughput

0.573

High

1179962

CCD57
Coiled-coil domain-containing protein 57

1

12

High-throughput

0.573

High

1217955

MYOME
Myomegalin

1

7

High-throughput

0.573

High

1230091

K1C40
Keratin, type I cytoskeletal 40

1

11

High-throughput

0.573

High

1239705

TRI69
E3 ubiquitin-protein ligase TRIM69

1

5

High-throughput

0.573

High

1239737

TSG10
Testis-specific gene 10 protein

1

17

High-throughput

0.573

High

1196266

GRAP1
GRIP1-associated protein 1

2

6

High-throughput

0.561

High

1117100

NACA
Nascent polypeptide-associated complex subunit alpha

1

2

Small-scale

0.561

High

65072

GG6L9
Golgin subfamily A member 6-like protein 9

2

19

High-throughput

0.553

High

300582

KRT36
Keratin, type I cuticular Ha6

2

11

High-throughput

0.553

High

1061522

ACTN3
Alpha-actinin-3

2

5

High-throughput

0.553

High

1216118

FHL5
Four and a half LIM domains protein 5

2

12

High-throughput

0.553

High

1239723

GCC1
GRIP and coiled-coil domain-containing protein 1

2

14

High-throughput

0.553

High

1239728

GMCL1
Germ cell-less protein-like 1

2

2

High-throughput

0.553

High

1239744

PKHF2
Pleckstrin homology domain-containing family F member 2

2

3

High-throughput

0.553

High

1239710

FAM9B
Protein FAM9B

1

0

High-throughput

0.549

High

637573

FLNA
Filamin-A

1

10

High-throughput

0.536

High

862875

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

4

High-throughput

0.536

High

934747

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.536

High

1160661

DREB
Drebrin

1

7

High-throughput

0.536

High

1239713

SYNPO
Synaptopodin

1

9

High-throughput

0.536

High

1239721

MY18A
Unconventional myosin-XVIIIa

1

5

High-throughput

0.536

High

1239727

MYO19
Unconventional myosin-XIX

1

6

High-throughput

0.536

High

1239761

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.536

High

587111

ITF2
Transcription factor 4

1

1

High-throughput

0.523

High

1239703

KCTD9
BTB/POZ domain-containing protein KCTD9

1

7

High-throughput

0.523

High

1239725

SPDLY
Protein Spindly

1

6

High-throughput

0.523

High

1239733

LZTS2
Leucine zipper putative tumor suppressor 2

1

19

High-throughput

0.523

High

116863

I6L9F6
NEFL protein

1

17

High-throughput

0.515

High

808093

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.513

High

1239757

PHF24
PHD finger protein 24

1

0

High-throughput

0.493

High

866727

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.489

High

1120204

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

8

High-throughput

0.489

High

1239741

CPVL
Probable serine carboxypeptidase CPVL

1

2

High-throughput

0.489

High

1239753

LIMA1
LIM domain and actin-binding protein 1

1

6

High-throughput

0.489

High

566277

K1C13
Keratin, type I cytoskeletal 13

1

9

High-throughput

0.481

High

893946

MEOX2
Homeobox protein MOX-2

1

2

High-throughput

0.481

High

1239719

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.481

High

1239720

TSC1
Hamartin

1

20

High-throughput

0.481

High

247963

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

331056

KI20A
Kinesin-like protein KIF20A

1

10

High-throughput

0.479

High

535188

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.479

High

556157

CADH1
Cadherin-1

1

5

High-throughput

0.479

High

563920

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.479

High

582842

EZRI
Ezrin

1

4

High-throughput

0.479

High

799216

BRCA1
Breast cancer type 1 susceptibility protein

1

8

High-throughput

0.479

High

952898

ACTB
Actin, cytoplasmic 1

1

6

High-throughput

0.479

High

1115733

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.479

High

1140428

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.479

High

1239702

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.479

High

1239718

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

1239742

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

1239750

HDAC6
Protein deacetylase HDAC6

1

7

High-throughput

0.479

High

49897

A1A4E9
Keratin 13

1

9

High-throughput

0.470

High

1194552

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

1232411

Q6FHY5
MEOX2 protein

1

2

High-throughput

0.470

High

1239706

Q86WV8
TSC complex subunit 1

1

1

High-throughput

0.470

High

1100836

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.458

High

1239748

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.458

High

1239754

SEPT9
Septin-9

1

0

Small-scale

0.458

High

1048886

REL
Proto-oncogene c-Rel

1

5

High-throughput

0.457

High

942686

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

16

High-throughput

0.445

High

1239701

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

1

Small-scale

0.445

High

157507

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.437

High

372312

MYC
Myc proto-oncogene protein

1

11

High-throughput

0.437

High

892685

DNLI4
DNA ligase 4

1

1

High-throughput

0.437

High

976343

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.437

High

1137774

TNIP1
TNFAIP3-interacting protein 1

1

18

High-throughput

0.437

High

1163650

PPR3A
Protein phosphatase 1 regulatory subunit 3A

1

1

High-throughput

0.437

High

1226878

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.437

High

1239752

TES
Testin

1

9

High-throughput

0.437

High

47267

A0A6Q8KRG2
Golgin subfamily A member 2

1

10

High-throughput

0.417

High

1239735

KIFC3
Kinesin-like protein KIFC3

1

1

High-throughput

0.417

High

765627

BMI1
Polycomb complex protein BMI-1

1

7

High-throughput

0.407

High

1103234

CTBP1
C-terminal-binding protein 1

1

5

High-throughput

0.407

High

1239732

ZBT18
Zinc finger and BTB domain-containing protein 18

1

1

High-throughput

0.407

High

1239738

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

1239709

TEX11
Testis-expressed protein 11

3

0

High-throughput

0.352

High

249984

OGA
Protein O-GlcNAcase

3

0

High-throughput

0.347

High

1239716

CEP70
Centrosomal protein of 70 kDa

3

0

High-throughput

0.339

High

269244

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.316

High

343768

LDOC1
Protein LDOC1

2

0

High-throughput

0.316

High

1239724

RM38
Large ribosomal subunit protein mL38

2

0

High-throughput

0.316

High

1239739

ZMY12
Zinc finger MYND domain-containing protein 12

2

0

High-throughput

0.316

High

1239759

EIF3L
Eukaryotic translation initiation factor 3 subunit L

2

0

High-throughput

0.316

High

1239760

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.316

High

1239715

CBY2
Protein chibby homolog 2

1

0

High-throughput

0.299

High

1239731

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025