Protein: ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial (HESB-like domain-containing protein 2) (Iron-sulfur assembly protein IscA) (hIscA)

Gene: ISCA1
Organism: Homo sapiens
Interactions: 89
UniProt ID: Q9BUE6

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0016226 - iron-sulfur cluster assembly
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1287728

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

3

7

Small-scale

0.847

High

501781

RB40L
Ras-related protein Rab-40A-like

3

3

High-throughput

0.667

High

920675

NUDT6
Nucleoside diphosphate-linked moiety X motif 6

3

1

High-throughput

0.667

High

1398696

AP4AT
AP-4 complex accessory subunit Tepsin

3

1

Small-scale

0.662

High

1410928

HSPB9
Heat shock protein beta-9

3

0

High-throughput

0.638

High

1090888

TRAF2
TNF receptor-associated factor 2

2

1

High-throughput

0.628

High

1363537

TRIB2
Tribbles homolog 2

2

2

High-throughput

0.628

High

1402072

TRIB1
Tribbles homolog 1

2

3

High-throughput

0.628

High

1370897

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

2

1

High-throughput

0.611

High

377242

SOM2
Growth hormone variant

3

2

High-throughput

0.609

High

1086746

RB40B
Ras-related protein Rab-40B

3

3

High-throughput

0.609

High

1360870

RB40A
Ras-related protein Rab-40A

3

3

High-throughput

0.609

High

1411266

LZTS2
Leucine zipper putative tumor suppressor 2

3

1

High-throughput

0.609

High

1116694

RIN1
Ras and Rab interactor 1

2

0

High-throughput

0.602

High

516050

CSH2
Chorionic somatomammotropin hormone 2

2

2

High-throughput

0.584

High

890677

RGS3
Regulator of G-protein signaling 3

2

1

High-throughput

0.574

High

516031

CSH1
Chorionic somatomammotropin hormone 1

2

2

High-throughput

0.552

High

1200397

BOLA3
BolA-like protein 3

1

1

High-throughput

0.536

High

1212531

CAF17
Iron-sulfur cluster assembly factor IBA57, mitochondrial

1

5

High-throughput

0.536

High

1248439

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

1

High-throughput

0.536

High

1315349

THNS1
Threonine synthase-like 1

1

1

High-throughput

0.536

High

1414159

TBD2A
TBC1 domain family member 2A

1

1

High-throughput

0.536

High

1414165

KIF15
Kinesin-like protein KIF15

1

1

High-throughput

0.536

High

166559

BACH1
Transcription regulator protein BACH1

1

0

High-throughput

0.513

High

177593

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.513

High

339182

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

0

High-throughput

0.513

High

560907

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

0

High-throughput

0.513

High

573228

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.513

High

575196

IDE
Insulin-degrading enzyme

1

0

High-throughput

0.513

High

709158

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.513

High

1036384

BDH
D-beta-hydroxybutyrate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1123405

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

1245056

TRI65
E3 ubiquitin-protein ligase TRIM65

1

0

High-throughput

0.513

High

1289014

NLRX1
NLR family member X1

1

0

High-throughput

0.513

High

1292077

SPA24
Spermatogenesis-associated protein 24

1

0

High-throughput

0.513

High

1294771

PTH
Peptidyl-tRNA hydrolase

1

0

High-throughput

0.513

High

1295157

DLP1
All trans-polyprenyl-diphosphate synthase PDSS2

1

0

High-throughput

0.513

High

1310368

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1337117

CHDH
Choline dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1338803

FAD1
FAD synthase

1

0

High-throughput

0.513

High

1360019

IL1FA
Interleukin-1 family member 10

1

0

High-throughput

0.513

High

1372225

TATD2
3'-5' RNA nuclease TATDN2

1

0

High-throughput

0.513

High

1400436

TPPC9
Trafficking protein particle complex subunit 9

1

0

High-throughput

0.513

High

1410805

NUD12
NAD-capped RNA hydrolase NUDT12

1

0

High-throughput

0.513

High

1410868

MGME1
Mitochondrial genome maintenance exonuclease 1

1

0

High-throughput

0.513

High

1414157

SELO
Protein adenylyltransferase SelO, mitochondrial

1

0

High-throughput

0.513

High

1414158

TGT
Queuine tRNA-ribosyltransferase catalytic subunit 1

1

0

High-throughput

0.513

High

1414160

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

0

High-throughput

0.513

High

1414166

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.513

High

1414169

NLK
Serine/threonine-protein kinase NLK

1

0

High-throughput

0.513

High

1414170

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.513

High

1414171

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

0

High-throughput

0.513

High

1414172

TPPC4
Trafficking protein particle complex subunit 4

1

0

High-throughput

0.513

High

1414173

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

317763

KBTBB
Kelch repeat and BTB domain-containing protein 11

1

1

High-throughput

0.489

High

913573

KIF11
Kinesin-like protein KIF11

1

1

High-throughput

0.489

High

1402154

RB40C
Ras-related protein Rab-40C

1

3

High-throughput

0.489

High

1414167

KLH42
Kelch-like protein 42

1

1

High-throughput

0.489

High

515730

TPC2B
Trafficking protein particle complex subunit 2B

1

0

High-throughput

0.458

High

691382

1433T
14-3-3 protein theta

1

0

High-throughput

0.458

High

1114169

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1142649

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1234509

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1381695

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

1392003

PLPR2
Phospholipid phosphatase-related protein type 2

3

0

High-throughput

0.347

High

1414156

WDR18
WD repeat-containing protein 18

3

0

High-throughput

0.347

High

351723

SG1D1
Secretoglobin family 1D member 1

2

0

High-throughput

0.328

High

1169512

LRC36
Leucine-rich repeat-containing protein 36

2

0

High-throughput

0.328

High

1414161

GORS2
Golgi reassembly-stacking protein 2

2

0

High-throughput

0.328

High

1142381

PDIA6
Protein disulfide-isomerase A6

2

0

High-throughput

0.318

High

1414162

ZMAT3
Zinc finger matrin-type protein 3

2

0

High-throughput

0.318

High

338536

SC24B
Protein transport protein Sec24B

1

0

High-throughput

0.279

Low

976922

ERR3
Estrogen-related receptor gamma

1

0

High-throughput

0.279

Low

1098117

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.279

Low

1196310

GRAP1
GRIP1-associated protein 1

1

0

High-throughput

0.279

Low

1199945

P5CR3
Pyrroline-5-carboxylate reductase 3

1

0

High-throughput

0.279

Low

1245011

SPSB3
SPRY domain-containing SOCS box protein 3

1

0

High-throughput

0.279

Low

1279024

TAFA3
Chemokine-like protein TAFA-3

1

0

High-throughput

0.279

Low

1312687

BAP18
BPTF-associated chromatin complex component 1

1

0

High-throughput

0.279

Low

1358498

TPC14
Trafficking protein particle complex subunit 14

1

0

High-throughput

0.279

Low

1391410

DUS3L
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like

1

0

High-throughput

0.279

Low

1400246

LENG8
Leukocyte receptor cluster member 8

1

0

High-throughput

0.279

Low

1402149

MTL26
Methyltransferase-like 26

1

0

High-throughput

0.279

Low

1414163

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.279

Low

1414164

ANLN
Anillin

1

0

High-throughput

0.279

Low

1414168

ORC3
Origin recognition complex subunit 3

1

0

High-throughput

0.279

Low

1208886

H2B2F
Histone H2B type 2-F

1

0

High-throughput

0.269

Low

941537

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.249

Low

1293130

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025