Protein: LYPD1
Ly6/PLAUR domain-containing protein 1 (Putative HeLa tumor suppressor) (PHTS)

Gene: LYPD1
Organism: Homo sapiens
Interactions: 131
UniProt ID: Q8N2G4

Gene Ontology (top 5):
GO:0001662 - behavioral fear response
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0007271 - synaptic transmission, cholinergic
GO:0030550 - acetylcholine receptor inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

551805

CO6A1

3

1

High-throughput

0.662

High

551878

CO6A2

3

1

High-throughput

0.662

High

833472

WNT5A
Protein Wnt-5a

3

1

High-throughput

0.662

High

997027

TBA4A
Tubulin alpha-4A chain

2

2

High-throughput

0.628

High

1259342

TBA1A
Tubulin alpha-1A chain

2

2

High-throughput

0.628

High

1324210

VWDE
von Willebrand factor D and EGF domain-containing protein

2

3

High-throughput

0.628

High

1324263

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

3

High-throughput

0.628

High

535290

BIP
Endoplasmic reticulum chaperone BiP

2

0

High-throughput

0.602

High

1144634

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

2

0

High-throughput

0.602

High

1291954

LRP11
Low-density lipoprotein receptor-related protein 11

2

0

High-throughput

0.602

High

296366

ATRN
Attractin

2

5

High-throughput

0.601

High

1272703

MAEA
E3 ubiquitin-protein transferase MAEA

2

1

High-throughput

0.601

High

1324292

AGRG1
Adhesion G-protein coupled receptor G1

2

2

High-throughput

0.601

High

1324277

PLS2
Phospholipid scramblase 2

2

0

High-throughput

0.580

High

844214

ECE1
Endothelin-converting enzyme 1

2

0

High-throughput

0.576

High

934242

BI1
Bax inhibitor 1

2

0

High-throughput

0.576

High

1191880

TBB8
Tubulin beta-8 chain

2

1

High-throughput

0.574

High

1324271

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

2

1

High-throughput

0.574

High

1281692

MEGF8
Multiple epidermal growth factor-like domains protein 8

2

9

High-throughput

0.549

High

274897

LRP5
Low-density lipoprotein receptor-related protein 5

1

1

High-throughput

0.536

High

287586

LRP6
Low-density lipoprotein receptor-related protein 6

1

1

High-throughput

0.536

High

462900

LAMB1
Laminin subunit beta-1

1

6

High-throughput

0.536

High

612096

ITB5
Integrin beta-5

1

1

High-throughput

0.536

High

720422

ACHA5
Neuronal acetylcholine receptor subunit alpha-5

1

2

High-throughput

0.536

High

931964

EPHB4
Ephrin type-B receptor 4

1

1

High-throughput

0.536

High

1047629

NOTC2
Neurogenic locus notch homolog protein 2

1

2

High-throughput

0.536

High

1105752

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

4

High-throughput

0.536

High

1213209

AGRF1
Adhesion G-protein coupled receptor F1

1

2

High-throughput

0.536

High

1294360

FRAS1
Extracellular matrix organizing protein FRAS1

1

4

High-throughput

0.536

High

1324274

ANTR1
Anthrax toxin receptor 1

1

2

High-throughput

0.536

High

1324279

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

1

1

High-throughput

0.536

High

1324285

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

1

4

High-throughput

0.536

High

1324286

ATS7
A disintegrin and metalloproteinase with thrombospondin motifs 7

1

3

High-throughput

0.536

High

1324289

JAG2
Protein jagged-2

1

2

High-throughput

0.536

High

354135

CLPT1
Putative lipid scramblase CLPTM1

1

0

High-throughput

0.513

High

520916

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.513

High

648588

FGFR4
Fibroblast growth factor receptor 4

1

0

High-throughput

0.513

High

1089114

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.513

High

1108799

ASAH1
Acid ceramidase

1

0

High-throughput

0.513

High

1307880

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.513

High

1324265

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.513

High

1108604

TBB3
Tubulin beta-3 chain

1

1

High-throughput

0.489

High

1206991

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

1

High-throughput

0.489

High

1324260

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.489

High

1324269

TBA1C
Tubulin alpha-1C chain

1

2

High-throughput

0.489

High

161059

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

4

High-throughput

0.445

High

183277

LAMA5
Laminin subunit alpha-5

1

7

High-throughput

0.445

High

324012

CSTN1
Calsyntenin-1

1

1

High-throughput

0.445

High

452103

PROS
Vitamin K-dependent protein S

1

3

High-throughput

0.445

High

465576

IGF1R
Insulin-like growth factor 1 receptor

1

1

High-throughput

0.445

High

472095

MET
Hepatocyte growth factor receptor

1

3

High-throughput

0.445

High

535867

LAMC1
Laminin subunit gamma-1

1

6

High-throughput

0.445

High

592674

ITB4
Integrin beta-4

1

1

High-throughput

0.445

High

772324

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

2

High-throughput

0.445

High

937413

LAMB2
Laminin subunit beta-2

1

4

High-throughput

0.445

High

946251

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

3

High-throughput

0.445

High

1098439

DNJC3
DnaJ homolog subfamily C member 3

1

1

High-throughput

0.445

High

1105219

S39A6
Zinc transporter ZIP6

1

1

High-throughput

0.445

High

1117003

LAMB3
Laminin subunit beta-3

1

5

High-throughput

0.445

High

1117034

LAMC2
Laminin subunit gamma-2

1

6

High-throughput

0.445

High

1177233

MICA
MHC class I polypeptide-related sequence A

1

1

High-throughput

0.445

High

1250377

PCD23
Protocadherin-23

1

1

High-throughput

0.445

High

1324261

PXDN
Peroxidasin homolog

1

1

High-throughput

0.445

High

1324273

C1QT2
Complement C1q tumor necrosis factor-related protein 2

1

2

High-throughput

0.445

High

1324284

PLXA1
Plexin-A1

1

1

High-throughput

0.445

High

1324288

S39AA
Zinc transporter ZIP10

1

1

High-throughput

0.445

High

1324293

WNT6
Protein Wnt-6

1

1

High-throughput

0.445

High

247527

FZD6
Frizzled-6

1

0

High-throughput

0.426

High

277025

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

0

High-throughput

0.426

High

287964

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

0

High-throughput

0.426

High

321300

ERLN2
Erlin-2

1

0

High-throughput

0.426

High

458701

SAP
Prosaposin

1

0

High-throughput

0.426

High

470373

INHBA
Inhibin beta A chain

1

0

High-throughput

0.426

High

633857

MPRD
Cation-dependent mannose-6-phosphate receptor

1

0

High-throughput

0.426

High

731929

L1CAM
Neural cell adhesion molecule L1

1

0

High-throughput

0.426

High

756568

GALNS
N-acetylgalactosamine-6-sulfatase

1

0

High-throughput

0.426

High

774781

TIMP3
Metalloproteinase inhibitor 3

1

0

High-throughput

0.426

High

787423

TGFR1
TGF-beta receptor type-1

1

0

High-throughput

0.426

High

937589

CAD13
Cadherin-13

1

0

High-throughput

0.426

High

977135

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.426

High

1023365

AT2C1
Calcium-transporting ATPase type 2C member 1

1

0

High-throughput

0.426

High

1087066

FSTL1
Follistatin-related protein 1

1

0

High-throughput

0.426

High

1322736

CNPY4
Protein canopy homolog 4

1

0

High-throughput

0.426

High

1324262

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.426

High

1324268

SORT
Sortilin

1

0

High-throughput

0.426

High

1324275

RHOF
Rho-related GTP-binding protein RhoF

1

0

High-throughput

0.426

High

1324283

CEIP2
Cell surface hyaluronidase CEMIP2

1

0

High-throughput

0.426

High

1324294

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

0

High-throughput

0.426

High

1006204

CNTP1
Contactin-associated protein 1

1

2

High-throughput

0.407

High

1231123

SCAR3
Scavenger receptor class A member 3

1

2

High-throughput

0.407

High

1231844

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

1

High-throughput

0.407

High

1244352

SKI3
Superkiller complex protein 3

1

1

High-throughput

0.407

High

1257524

TMTC3
Protein O-mannosyl-transferase TMTC3

1

1

High-throughput

0.407

High

1324278

GID8
Glucose-induced degradation protein 8 homolog

1

1

High-throughput

0.407

High

1324287

MKLN1
Muskelin

1

1

High-throughput

0.407

High

1245003

SPSB3
SPRY domain-containing SOCS box protein 3

3

0

High-throughput

0.345

High

945756

ISK7
Serine protease inhibitor Kazal-type 7

2

0

High-throughput

0.328

High

1141586

OZF
Zinc finger protein OZF

2

0

High-throughput

0.328

High

1154248

NPTX1
Neuronal pentraxin-1

2

0

High-throughput

0.328

High

1208454

EOGT
EGF domain-specific O-linked N-acetylglucosamine transferase

2

0

High-throughput

0.328

High

1324276

RAB6B
Ras-related protein Rab-6B

2

0

High-throughput

0.328

High

1324266

RUSF1
RUS family member 1

2

0

High-throughput

0.313

High

1324291

LOXL2
Lysyl oxidase homolog 2

2

0

High-throughput

0.313

High

335629

AGM1
Phosphoacetylglucosamine mutase

1

0

High-throughput

0.279

Low

1288090

OAF
Out at first protein homolog

1

0

High-throughput

0.279

Low

1324267

MYO19
Unconventional myosin-XIX

1

0

High-throughput

0.279

Low

327616

ELP1
Elongator complex protein 1

1

0

High-throughput

0.232

Low

335694

MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

1

0

High-throughput

0.232

Low

749621

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

0

High-throughput

0.232

Low

884834

PPM1F
Protein phosphatase 1F

1

0

High-throughput

0.232

Low

885544

PRI1
DNA primase small subunit

1

0

High-throughput

0.232

Low

885592

PRI2
DNA primase large subunit

1

0

High-throughput

0.232

Low

1105511

OS9
Protein OS-9

1

0

High-throughput

0.232

Low

1117244

NCOA4
Nuclear receptor coactivator 4

1

0

High-throughput

0.232

Low

1162139

MA2A1
Alpha-mannosidase 2

1

0

High-throughput

0.232

Low

1210724

ZMYM1
Zinc finger MYM-type protein 1

1

0

High-throughput

0.232

Low

1228512

TENS3
Tensin-3

1

0

High-throughput

0.232

Low

1233987

ASPH2
Aspartate beta-hydroxylase domain-containing protein 2

1

0

High-throughput

0.232

Low

1235718

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

0

High-throughput

0.232

Low

1248271

MOXD1
DBH-like monooxygenase protein 1

1

0

High-throughput

0.232

Low

1279198

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.232

Low

1286281

GALT7
N-acetylgalactosaminyltransferase 7

1

0

High-throughput

0.232

Low

1324258

DTWD2
tRNA-uridine aminocarboxypropyltransferase 2

1

0

High-throughput

0.232

Low

1324259

DNJA4
DnaJ homolog subfamily A member 4

1

0

High-throughput

0.232

Low

1324264

DOC10
Dedicator of cytokinesis protein 10

1

0

High-throughput

0.232

Low

1324270

PAAF1
Proteasomal ATPase-associated factor 1

1

0

High-throughput

0.232

Low

1324272

SYTM
Threonine--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low

1324280

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

0

High-throughput

0.232

Low

1324281

CHPF2
Chondroitin sulfate glucuronyltransferase

1

0

High-throughput

0.232

Low

1324282

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.232

Low

1324290

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025