Protein: GPN3
GPN-loop GTPase 3 (ATP-binding domain 1 family member C)

Gene: GPN3
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q9UHW5

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0032991 - protein-containing complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1439343

GPN1
GPN-loop GTPase 1

8

10

Small-scale

0.964

High

1313076

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

7

3

High-throughput

0.682

High

430659

RPC4
DNA-directed RNA polymerase III subunit RPC4

5

1

High-throughput

0.654

High

976175

RPB7
DNA-directed RNA polymerase II subunit RPB7

5

4

High-throughput

0.654

High

1450826

RPC5
DNA-directed RNA polymerase III subunit RPC5

5

1

High-throughput

0.654

High

1451010

RPC2
DNA-directed RNA polymerase III subunit RPC2

5

13

High-throughput

0.654

High

1451309

PIHD1
PIH1 domain-containing protein 1

5

1

High-throughput

0.650

High

180430

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

4

8

High-throughput

0.638

High

621788

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

8

High-throughput

0.638

High

959086

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

4

3

High-throughput

0.638

High

723136

RPB2
DNA-directed RNA polymerase II subunit RPB2

4

13

High-throughput

0.636

High

932151

EPHA4
Ephrin type-A receptor 4

4

1

High-throughput

0.635

High

165107

RPC1
DNA-directed RNA polymerase III subunit RPC1

4

9

High-throughput

0.630

High

192881

RPB4
DNA-directed RNA polymerase II subunit RPB4

4

1

High-throughput

0.630

High

262330

SCN2B
Sodium channel regulatory subunit beta-2

4

2

High-throughput

0.630

High

667501

RPB1
DNA-directed RNA polymerase II subunit RPB1

4

9

High-throughput

0.630

High

912258

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

4

7

High-throughput

0.630

High

1460106

RPC10
DNA-directed RNA polymerase III subunit RPC10

4

5

High-throughput

0.630

High

1232044

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

4

2

High-throughput

0.617

High

622006

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

3

High-throughput

0.616

High

191149

RPA34
DNA-directed RNA polymerase I subunit RPA34

3

1

High-throughput

0.609

High

340057

RPA1
DNA-directed RNA polymerase I subunit RPA1

3

9

High-throughput

0.609

High

787813

RPB9
DNA-directed RNA polymerase II subunit RPB9

3

5

High-throughput

0.609

High

983730

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

3

4

High-throughput

0.609

High

1428666

RPA49
DNA-directed RNA polymerase I subunit RPA49

3

1

High-throughput

0.609

High

1437326

RPA2
DNA-directed RNA polymerase I subunit RPA2

3

13

High-throughput

0.609

High

1447100

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

3

6

High-throughput

0.609

High

1458389

CRNN
Cornulin

3

1

High-throughput

0.609

High

1460109

RPC8
DNA-directed RNA polymerase III subunit RPC8

3

4

High-throughput

0.609

High

1416458

GTPB2
GTP-binding protein 2

2

1

High-throughput

0.606

High

1458458

UXT
Protein UXT

3

1

High-throughput

0.604

High

132367

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

3

Small-scale

0.599

High

316459

RMP
Unconventional prefoldin RPB5 interactor 1

3

1

Small-scale

0.593

High

333249

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

1

High-throughput

0.574

High

681946

RBTN2
Rhombotin-2

2

1

High-throughput

0.574

High

506041

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

3

2

High-throughput

0.558

High

516885

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

3

7

High-throughput

0.558

High

1399375

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

2

6

High-throughput

0.558

High

1240982

S27A4
Long-chain fatty acid transport protein 4

2

2

High-throughput

0.549

High

1435193

RPAP3
RNA polymerase II-associated protein 3

2

1

High-throughput

0.549

High

188606

SIGL5
Sialic acid-binding Ig-like lectin 5

1

1

High-throughput

0.489

High

1403469

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

212501

SPIT2
Kunitz-type protease inhibitor 2

1

1

High-throughput

0.489

High

239632

MED14
Mediator of RNA polymerase II transcription subunit 14

1

2

High-throughput

0.489

High

640320

EPHA1
Ephrin type-A receptor 1

1

1

High-throughput

0.489

High

912153

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

3

High-throughput

0.489

High

923564

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

5

High-throughput

0.489

High

1245018

SPSB3
SPRY domain-containing SOCS box protein 3

1

2

High-throughput

0.489

High

1330756

SIGL1
SIGLEC family-like protein 1

1

1

High-throughput

0.489

High

1347164

WDR48
WD repeat-containing protein 48

1

2

High-throughput

0.489

High

1364840

F168A
Protein FAM168A

1

1

High-throughput

0.489

High

1371892

CUL5
Cullin-5

1

3

High-throughput

0.489

High

1397679

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

1420330

CD244
Natural killer cell receptor 2B4

1

1

High-throughput

0.489

High

1430226

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

3

High-throughput

0.489

High

1450389

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.489

High

1460094

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.489

High

173514

XPO1
Exportin-1

1

13

High-throughput

0.479

High

799554

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

117171

J9JIF5
CXXC-type zinc finger protein 4

1

1

High-throughput

0.437

High

316123

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.437

High

508792

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.437

High

862526

YAP1
Transcriptional coactivator YAP1

1

5

Small-scale

0.437

High

1114583

CUL3
Cullin-3

1

3

High-throughput

0.437

High

1178448

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

1217634

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

5

High-throughput

0.437

High

1435415

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.437

High

1459209

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

564518

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

171607

S27A2
Long-chain fatty acid transport protein 2

1

2

High-throughput

0.407

High

505990

MYZAP
Myocardial zonula adherens protein

1

2

High-throughput

0.407

High

516812

RPC22
Protein POLR1D, isoform 2

1

1

High-throughput

0.407

High

1243676

S27A1
Long-chain fatty acid transport protein 1

1

2

High-throughput

0.407

High

1340255

MSPD2
Motile sperm domain-containing protein 2

1

1

High-throughput

0.407

High

1431892

CXXC4
CXXC-type zinc finger protein 4

1

1

High-throughput

0.407

High

968028

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

3

0

High-throughput

0.347

High

1460108

DAAM1
Disheveled-associated activator of morphogenesis 1

3

0

High-throughput

0.347

High

244782

ZC3H1
Zinc finger C3H1 domain-containing protein

2

0

High-throughput

0.328

High

630197

ACM3
Muscarinic acetylcholine receptor M3

2

0

High-throughput

0.328

High

1293930

VSIG1
V-set and immunoglobulin domain-containing protein 1

2

0

High-throughput

0.328

High

1409721

MICU1
Calcium uptake protein 1, mitochondrial

2

0

High-throughput

0.328

High

1451557

ASB6
Ankyrin repeat and SOCS box protein 6

2

0

High-throughput

0.328

High

1316895

ASPM
Abnormal spindle-like microcephaly-associated protein

2

0

High-throughput

0.318

High

218927

TGON2
Trans-Golgi network integral membrane protein 2

2

0

High-throughput

0.313

High

1398626

DAA10
Dynein axonemal assembly factor 10

2

0

High-throughput

0.313

High

1449787

PDRG1
p53 and DNA damage-regulated protein 1

2

0

High-throughput

0.313

High

1451138

MED9
Mediator of RNA polymerase II transcription subunit 9

2

0

High-throughput

0.313

High

49033

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.279

Low

216845

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.279

Low

277044

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

0

High-throughput

0.279

Low

675197

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.279

Low

848088

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

0

High-throughput

0.279

Low

922410

CRBB1
Beta-crystallin B1

1

0

High-throughput

0.279

Low

1187335

CMA1D
Protein CIMAP1D

1

0

High-throughput

0.279

Low

1270353

SPT6H
Transcription elongation factor SPT6

1

0

High-throughput

0.279

Low

1273915

BHA15
Class A basic helix-loop-helix protein 15

1

0

High-throughput

0.279

Low

1291704

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

1291917

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

0

High-throughput

0.279

Low

1310507

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1325050

EH1L1
EH domain-binding protein 1-like protein 1

1

0

High-throughput

0.279

Low

1349142

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1402680

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.279

Low

1403824

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.279

Low

1414152

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

High-throughput

0.279

Low

1458486

P2RX2
P2X purinoceptor 2

1

0

High-throughput

0.279

Low

1460105

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.279

Low

1460107

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.279

Low

613214

EGR1
Early growth response protein 1

1

0

High-throughput

0.249

Low

879590

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

1429387

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

336040

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

High-throughput

0.232

Low

1227651

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low

1314471

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.232

Low

1460104

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025