Protein: TSHR
Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R)

Gene: TSHR
Organism: Homo sapiens
Interactions: 84
UniProt ID: P16473

Gene Ontology (top 5):
GO:0004996 - thyroid-stimulating hormone receptor activity
GO:0005886 - plasma membrane
GO:0007166 - cell surface receptor signaling pathway
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007187 - G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

596976

PTK7
Inactive tyrosine-protein kinase 7

2

12

High-throughput

0.789

High

596982

SCRIB
Protein scribble homolog

1

20

Small-scale

0.756

High

596964

AA1R
Adenosine receptor A1

1

19

High-throughput

0.752

High

458267

ADRB2
Beta-2 adrenergic receptor

1

17

Small-scale

0.713

High

596986

MOG
Myelin-oligodendrocyte glycoprotein

1

3

High-throughput

0.698

High

541318

FGFR1
Fibroblast growth factor receptor 1

1

7

High-throughput

0.691

High

580727

PVR
Poliovirus receptor

1

6

High-throughput

0.691

High

597008

NEUR1
Sialidase-1

1

0

High-throughput

0.656

High

534598

BIP
Endoplasmic reticulum chaperone BiP

2

6

Small-scale

0.611

High

597000

TBA1A
Tubulin alpha-1A chain

2

10

High-throughput

0.611

High

62901

POTEF
POTE ankyrin domain family member F

3

10

High-throughput

0.609

High

596987

LAMA3
Laminin subunit alpha-3

3

8

High-throughput

0.609

High

596968

MLF1
Myeloid leukemia factor 1

2

1

High-throughput

0.574

High

547085

PYC
Pyruvate carboxylase, mitochondrial

2

2

High-throughput

0.558

High

596957

SYT1
Synaptotagmin-1

1

0

High-throughput

0.558

High

596979

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.553

High

596969

CD81
CD81 antigen

1

9

High-throughput

0.541

High

596970

ACTB
Actin, cytoplasmic 1

1

6

High-throughput

0.541

High

457213

TBB5
Tubulin beta chain

1

9

High-throughput

0.536

High

596962

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

9

High-throughput

0.536

High

596997

CSPG4
Chondroitin sulfate proteoglycan 4

1

3

High-throughput

0.536

High

597018

JAG2
Protein jagged-2

1

4

High-throughput

0.536

High

597022

AGRG1
Adhesion G-protein coupled receptor G1

1

6

High-throughput

0.536

High

596991

TM119
Transmembrane protein 119

1

0

High-throughput

0.518

High

597004

JPH3
Junctophilin-3

1

0

High-throughput

0.518

High

596961

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

9

Small-scale

0.515

High

175317

PLXB2
Plexin-B2

1

0

High-throughput

0.513

High

370001

TIMP1
Metalloproteinase inhibitor 1

1

0

High-throughput

0.513

High

596963

ACHA5
Neuronal acetylcholine receptor subunit alpha-5

1

0

High-throughput

0.513

High

596973

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.513

High

596981

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

0

High-throughput

0.513

High

596988

T132A
Transmembrane protein 132A

1

0

High-throughput

0.513

High

597011

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.513

High

388997

FINC
Fibronectin

1

7

Small-scale

0.501

High

484897

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.494

High

596966

PTSS1
Phosphatidylserine synthase 1

1

3

High-throughput

0.494

High

596992

RUN3A
RUN domain-containing protein 3A

1

2

High-throughput

0.494

High

596998

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

1

1

High-throughput

0.494

High

407970

TBB4A
Tubulin beta-4A chain

1

9

High-throughput

0.489

High

462841

LAMB1
Laminin subunit beta-1

1

7

High-throughput

0.489

High

535816

LAMC1
Laminin subunit gamma-1

1

6

High-throughput

0.489

High

596967

LAMB2
Laminin subunit beta-2

1

8

High-throughput

0.489

High

596971

TBA4A
Tubulin alpha-4A chain

1

9

High-throughput

0.489

High

596983

DPOD3
DNA polymerase delta subunit 3

1

2

High-throughput

0.489

High

596984

NOMO1
BOS complex subunit NOMO1

1

1

High-throughput

0.489

High

596989

TBB8
Tubulin beta-8 chain

1

9

High-throughput

0.489

High

596995

SPSB3
SPRY domain-containing SOCS box protein 3

1

5

High-throughput

0.489

High

596999

CREL2
Protein disulfide isomerase CRELD2

1

4

High-throughput

0.489

High

597002

MIRO2
Mitochondrial Rho GTPase 2

1

12

High-throughput

0.489

High

597014

SG196
Protein O-mannose kinase

1

20

High-throughput

0.489

High

597015

ESRP2
Epithelial splicing regulatory protein 2

1

4

High-throughput

0.489

High

253290

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.479

High

596958

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.479

High

596959

CALR
Calreticulin

1

10

Small-scale

0.479

High

596965

STAT3
Signal transducer and activator of transcription 3

1

2

Small-scale

0.479

High

596980

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

3

High-throughput

0.479

High

597013

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

596978

SMAD4
Mothers against decapentaplegic homolog 4

1

1

High-throughput

0.462

High

596960

CALX
Calnexin

1

10

Small-scale

0.437

High

596974

GOGA2
Golgin subfamily A member 2

1

6

High-throughput

0.437

High

596996

SAMD1
Sterile alpha motif domain-containing protein 1

1

3

High-throughput

0.437

High

597021

SALL2
Sal-like protein 2

1

1

High-throughput

0.437

High

278007

FLNB
Filamin-B

1

11

Small-scale

0.408

High

596994

BORA
Protein aurora borealis

3

0

High-throughput

0.347

High

597005

MOCOS
Molybdenum cofactor sulfurase

3

0

High-throughput

0.347

High

597010

ITPA
Inosine triphosphate pyrophosphatase

3

0

High-throughput

0.347

High

597003

TRM44
Probable tRNA

2

0

High-throughput

0.318

High

597009

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

2

0

High-throughput

0.318

High

597020

FBX7
F-box only protein 7

2

0

High-throughput

0.318

High

597016

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.304

High

596972

CRADD
Death domain-containing protein CRADD

1

0

High-throughput

0.282

High

596975

SEC20
Vesicle transport protein SEC20

1

0

High-throughput

0.282

High

596993

ASPH1
Aspartate beta-hydroxylase domain-containing protein 1

1

0

High-throughput

0.282

High

228797

SCO2
Protein SCO2 homolog, mitochondrial

1

0

High-throughput

0.279

Low

288896

ERAL1
GTPase Era, mitochondrial

1

0

High-throughput

0.279

Low

596977

OS9
Protein OS-9

1

0

High-throughput

0.279

Low

596990

ERFE
Erythroferrone

1

0

High-throughput

0.279

Low

597001

OAF
Out at first protein homolog

1

0

High-throughput

0.279

Low

597006

NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

1

0

High-throughput

0.279

Low

597007

NAR5
Ecto-ADP-ribosyltransferase 5

1

0

High-throughput

0.279

Low

597012

LMA2L
VIP36-like protein

1

0

High-throughput

0.279

Low

597017

T11L1
T-complex protein 11-like protein 1

1

0

High-throughput

0.279

Low

597019

MA2B2
Epididymis-specific alpha-mannosidase

1

0

High-throughput

0.279

Low

596985

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025