Protein: AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase)

Gene: AL4A1, ALDH4A1
Organism: Homo sapiens
Interactions: 72
UniProt ID: P30038

Gene Ontology (top 5):
GO:0003842 - L-glutamate gamma-semialdehyde dehydrogenase activity
GO:0004029 - aldehyde dehydrogenase (NAD+) activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

716096

AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

2

14

Small-scale

0.777

High

716119

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

3

3

Small-scale

0.640

High

716103

ARRB1
Beta-arrestin-1

2

0

High-throughput

0.602

High

291755

STK16
Serine/threonine-protein kinase 16

1

1

High-throughput

0.536

High

529159

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.536

High

690461

KAD4
Adenylate kinase 4, mitochondrial

1

3

High-throughput

0.536

High

716112

RBBP4
Histone-binding protein RBBP4

1

8

High-throughput

0.515

High

716098

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

0

High-throughput

0.513

High

716121

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

0

High-throughput

0.513

High

716123

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

716131

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

716136

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.513

High

716144

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

716145

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

185450

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

4

High-throughput

0.501

High

421563

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

165907

FFAR1
Free fatty acid receptor 1

1

2

High-throughput

0.489

High

325288

OR2A4
Olfactory receptor 2A4

1

4

High-throughput

0.489

High

716117

RB33A
Ras-related protein Rab-33A

1

5

High-throughput

0.489

High

716128

OIT3
Oncoprotein-induced transcript 3 protein

1

1

High-throughput

0.489

High

240839

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

279662

CISY
Citrate synthase, mitochondrial

1

3

High-throughput

0.479

High

281891

MPPB
Mitochondrial-processing peptidase subunit beta

1

4

High-throughput

0.479

High

350796

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

716100

MDHM
Malate dehydrogenase, mitochondrial

1

5

High-throughput

0.479

High

716101

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

716104

EFTU
Elongation factor Tu, mitochondrial

1

5

High-throughput

0.479

High

716110

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

716111

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

3

High-throughput

0.479

High

716113

MPPA
Mitochondrial-processing peptidase subunit alpha

1

4

High-throughput

0.479

High

716116

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

2

High-throughput

0.479

High

716118

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

716120

MRM1
rRNA methyltransferase 1, mitochondrial

1

2

High-throughput

0.479

High

716130

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

716134

TR61B
tRNA

1

1

High-throughput

0.479

High

716135

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

2

High-throughput

0.479

High

716138

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

716140

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

716141

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

716142

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

1

High-throughput

0.479

High

716143

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

423610

ARGI1
Arginase-1

1

0

High-throughput

0.460

High

716133

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

716105

ERF
ETS domain-containing transcription factor ERF

1

2

High-throughput

0.445

High

716107

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.445

High

716126

FXL16
F-box/LRR-repeat protein 16

1

1

High-throughput

0.445

High

105409

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

716099

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

716108

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.437

High

716114

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.437

High

716125

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

248840

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

425775

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

0

High-throughput

0.426

High

716106

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.426

High

716115

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

716122

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.426

High

716127

SKA2
Spindle and kinetochore-associated protein 2

1

0

High-throughput

0.426

High

716139

EXOC1
Exocyst complex component 1

1

0

High-throughput

0.426

High

261097

NSMA
Sphingomyelin phosphodiesterase 2

1

3

High-throughput

0.407

High

437629

HEPS
Serine protease hepsin

1

2

High-throughput

0.407

High

716109

IL5RA
Interleukin-5 receptor subunit alpha

1

1

High-throughput

0.407

High

716124

T184A
Transmembrane protein 184A

2

0

High-throughput

0.328

High

716097

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.279

Low

716132

LRC46
Leucine-rich repeat-containing protein 46

1

0

High-throughput

0.279

Low

716146

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

694698

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

716102

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

466870

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.232

Low

607906

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

0

High-throughput

0.232

Low

716129

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low

716137

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025