Protein: ARGI1
Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase)

Gene: ARGI1, ARG1
Organism: Homo sapiens
Interactions: 146
UniProt ID: P05089

Gene Ontology (top 5):
GO:0000050 - urea cycle
GO:0002250 - adaptive immune response
GO:0004053 - arginase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

423632

ARGI2
Arginase-2, mitochondrial

2

3

High-throughput

0.789

High

423659

ZIC1
Zinc finger protein ZIC 1

2

0

High-throughput

0.602

High

423658

EZH2
Histone-lysine N-methyltransferase EZH2

2

2

High-throughput

0.601

High

423711

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.586

High

395313

ESR1
Estrogen receptor

2

0

High-throughput

0.576

High

370909

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.571

High

423656

TNIP1
TNFAIP3-interacting protein 1

2

0

High-throughput

0.559

High

423653

GPR18
N-arachidonyl glycine receptor

2

1

High-throughput

0.558

High

423721

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

0

Small-scale

0.537

High

423620

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.536

High

423621

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.536

High

423628

MAX
Protein max

1

1

High-throughput

0.536

High

423634

CBX1
Chromobox protein homolog 1

1

2

High-throughput

0.536

High

423648

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.536

High

423699

PCGF6
Polycomb group RING finger protein 6

1

4

High-throughput

0.536

High

423712

WRP73
WD repeat-containing protein WRAP73

1

3

High-throughput

0.536

High

273389

KDM4A
Lysine-specific demethylase 4A

1

0

High-throughput

0.513

High

282652

E2F6
Transcription factor E2F6

1

0

High-throughput

0.513

High

352662

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.513

High

376965

ANF
Natriuretic peptides A

1

0

High-throughput

0.513

High

423605

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

0

High-throughput

0.513

High

423611

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.513

High

423613

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.513

High

423623

ATX1
Ataxin-1

1

0

High-throughput

0.513

High

423624

DSCR6
Protein ripply3

1

0

High-throughput

0.513

High

423625

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.513

High

423630

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.513

High

423639

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

0

High-throughput

0.513

High

423649

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

423662

VWA3B
von Willebrand factor A domain-containing protein 3B

1

0

High-throughput

0.513

High

423671

APTX
Aprataxin

1

0

High-throughput

0.513

High

423675

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.513

High

423677

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.513

High

423678

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

0

High-throughput

0.513

High

423682

SETD7
Histone-lysine N-methyltransferase SETD7

1

0

High-throughput

0.513

High

423684

THAP4
Peroxynitrite isomerase THAP4

1

0

High-throughput

0.513

High

423689

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

0

High-throughput

0.513

High

423697

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

423703

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

0

High-throughput

0.513

High

423704

COE2
Transcription factor COE2

1

0

High-throughput

0.513

High

423705

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.513

High

423710

EHF
ETS homologous factor

1

0

High-throughput

0.513

High

423716

PHF8
Histone lysine demethylase PHF8

1

0

High-throughput

0.513

High

423617

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

1

0

High-throughput

0.493

High

423655

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.493

High

423627

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

302314

RNF8
E3 ubiquitin-protein ligase RNF8

1

2

High-throughput

0.479

High

323091

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.479

High

423601

PLAK
Junction plakoglobin

1

1

High-throughput

0.479

High

423604

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

423614

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.479

High

423636

DSG1
Desmoglein-1

1

1

High-throughput

0.479

High

423644

RBBP4
Histone-binding protein RBBP4

1

2

High-throughput

0.479

High

423645

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

423652

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

High-throughput

0.479

High

423654

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

423679

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.479

High

423680

POC1B
POC1 centriolar protein homolog B

1

2

High-throughput

0.479

High

423695

RANB9
Ran-binding protein 9

1

1

Small-scale

0.479

High

423698

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

423713

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

423717

FBW1A
F-box/WD repeat-containing protein 1A

1

2

High-throughput

0.479

High

423720

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

423610

AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

0

High-throughput

0.460

High

238348

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

293048

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

370256

CYTA
Cystatin-A

1

0

High-throughput

0.458

High

413003

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

423597

ANXA2
Annexin A2

1

0

High-throughput

0.458

High

423598

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

423599

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

423600

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

423602

DESP
Desmoplakin

1

0

High-throughput

0.458

High

423603

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

423606

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

423607

SPR1B
Cornifin-B

1

0

High-throughput

0.458

High

423608

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.458

High

423609

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

423612

CASPE
Caspase-14

1

0

High-throughput

0.458

High

423616

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

423619

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

423622

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

423629

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

423631

1433Z
14-3-3 protein zeta/delta

1

0

Small-scale

0.458

High

423633

DCD
Dermcidin

1

0

High-throughput

0.458

High

423635

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.458

High

423637

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

Small-scale

0.458

High

423638

K1C17
Keratin, type I cytoskeletal 17

1

0

High-throughput

0.458

High

423640

SRSF1
Serine/arginine-rich splicing factor 1

1

0

High-throughput

0.458

High

423641

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

High-throughput

0.458

High

423647

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

423650

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.458

High

423651

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.458

High

423657

CDSN
Corneodesmosin

1

0

High-throughput

0.458

High

423660

SEPT7
Septin-7

1

0

High-throughput

0.458

High

423661

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

423663

FILA2
Filaggrin-2

1

0

High-throughput

0.458

High

423665

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

423666

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.458

High

423668

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

423672

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

423681

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.458

High

423683

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

High-throughput

0.458

High

423685

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

423686

RBP56
TATA-binding protein-associated factor 2N

1

0

High-throughput

0.458

High

423690

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

Small-scale

0.458

High

423694

SPB12
Serpin B12

1

0

High-throughput

0.458

High

423700

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

423701

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.458

High

423702

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

423707

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

423708

ANLN
Anillin

1

0

High-throughput

0.458

High

423714

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.458

High

423715

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

423718

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

0

Small-scale

0.458

High

327727

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

2

High-throughput

0.445

High

423626

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

2

High-throughput

0.445

High

423642

LG3BP
Galectin-3-binding protein

1

1

High-throughput

0.445

High

423646

TRAF2
TNF receptor-associated factor 2

1

2

High-throughput

0.445

High

423687

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.445

High

423669

WDR82
WD repeat-containing protein 82

1

2

High-throughput

0.437

High

423709

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

423664

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

423676

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.426

High

423692

MITOK
Mitochondrial potassium channel

3

0

High-throughput

0.347

High

222343

TSN6
Tetraspanin-6

1

0

High-throughput

0.279

Low

252501

SEP15
Selenoprotein F

1

0

High-throughput

0.279

Low

325260

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

423618

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

423670

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

High-throughput

0.279

Low

423688

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.279

Low

423691

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

423693

CABS1
Calcium-binding and spermatid-specific protein 1

1

0

High-throughput

0.279

Low

423696

SH23A
SH2 domain-containing protein 3A

1

0

High-throughput

0.279

Low

423706

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

0

High-throughput

0.279

Low

423719

FCF1
rRNA-processing protein FCF1 homolog

1

0

High-throughput

0.279

Low

299024

FLOT1
Flotillin-1

1

0

Small-scale

0.275

Low

105109

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

411174

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

423615

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

423643

DSC1
Desmocollin-1

1

0

High-throughput

0.249

Low

423667

KPLCE
Protein KPLCE

1

0

High-throughput

0.249

Low

423673

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

423674

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.249

Low

87298

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

254730

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025