Protein: ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 5)

Gene: ACSM5
Organism: Homo sapiens
Interactions: 54
UniProt ID: Q6NUN0

Gene Ontology (top 5):
GO:0004321 - fatty-acyl-CoA synthase activity
GO:0005524 - ATP binding
GO:0005525 - GTP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1238405

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

2

9

High-throughput

0.811

High

1194745

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

1

8

High-throughput

0.691

High

273069

CLU
Clustered mitochondria protein homolog

2

1

High-throughput

0.628

High

425812

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

2

1

High-throughput

0.628

High

725615

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

2

3

High-throughput

0.628

High

1138845

SYLM
Leucine--tRNA ligase, mitochondrial

2

1

High-throughput

0.628

High

1238402

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

2

1

High-throughput

0.628

High

1238409

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

2

2

High-throughput

0.628

High

649891

ADRO
NADPH:adrenodoxin oxidoreductase, mitochondrial

2

0

High-throughput

0.602

High

894475

PPOX
Protoporphyrinogen oxidase

2

0

High-throughput

0.602

High

926093

DPOG1
DNA polymerase subunit gamma-1

2

0

High-throughput

0.602

High

1238408

SYNM
Asparaginyl-tRNA synthetase

2

0

High-throughput

0.602

High

1238414

SYIM
Isoleucine--tRNA ligase, mitochondrial

2

0

High-throughput

0.602

High

61528

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.536

High

71742

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

1

High-throughput

0.536

High

271062

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

1

1

High-throughput

0.536

High

425918

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

1

High-throughput

0.536

High

522784

NR2F6
Nuclear receptor subfamily 2 group F member 6

1

1

High-throughput

0.536

High

532675

CH60
60 kDa heat shock protein, mitochondrial

1

6

High-throughput

0.536

High

662784

CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

1

2

High-throughput

0.536

High

846011

CACP
Carnitine O-acetyltransferase

1

2

High-throughput

0.536

High

884652

SYHM
Histidine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

1238404

NSUN4
5-cytosine rRNA methyltransferase NSUN4

1

1

High-throughput

0.536

High

1238407

SYMM
Methionine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

1238410

MIPEP
Mitochondrial intermediate peptidase

1

1

High-throughput

0.536

High

1238412

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.536

High

1238417

SARDH
Sarcosine dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

1238418

MTO1
5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial

1

1

High-throughput

0.536

High

1238419

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

66221

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.513

High

166672

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.513

High

177557

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.513

High

223835

NDUA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

0

High-throughput

0.513

High

322253

GLSK
Glutaminase kidney isoform, mitochondrial

1

0

High-throughput

0.513

High

643238

MUTA
Methylmalonyl-CoA mutase, mitochondrial

1

0

High-throughput

0.513

High

716121

AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1061337

CP24A
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

1

0

High-throughput

0.513

High

1205713

SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

1

0

High-throughput

0.513

High

1207042

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1215586

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.513

High

1235399

ACD10
Acyl-CoA dehydrogenase family member 10

1

0

High-throughput

0.513

High

1238398

SYDM
Aspartate--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1238399

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.513

High

1238400

NLRX1
NLR family member X1

1

0

High-throughput

0.513

High

1238401

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

1

0

High-throughput

0.513

High

1238403

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.513

High

1238406

COQ8B
Atypical kinase COQ8B, mitochondrial

1

0

High-throughput

0.513

High

1238411

SYTM
Threonine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1238413

RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

1238415

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.513

High

1067436

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.439

High

1212787

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.279

Low

1238416

ZPI
Protein Z-dependent protease inhibitor

1

0

High-throughput

0.279

Low

1068234

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025