Protein: MRM2
rRNA methyltransferase 2, mitochondrial (EC 2.1.1.-) (16S rRNA (uridine(1369)-2'-O)-methyltransferase) (16S rRNA [Um1369] 2'-O-methyltransferase) (Protein ftsJ homolog 2)

Gene: MRM2
Organism: Homo sapiens
Interactions: 91
UniProt ID: Q9UI43

Gene Ontology (top 5):
GO:0000451 - rRNA 2'-O-methylation
GO:0001510 - RNA methylation
GO:0005730 - nucleolus
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1435670

WDR26
WD repeat-containing protein 26

1

3

High-throughput

0.691

High

533047

CH60
60 kDa heat shock protein, mitochondrial

3

2

High-throughput

0.662

High

467730

CEL2B
Chymotrypsin-like elastase family member 2B

3

1

High-throughput

0.609

High

1293476

NIT1
Deaminated glutathione amidase

2

0

High-throughput

0.602

High

786297

LONM
Lon protease homolog, mitochondrial

2

2

High-throughput

0.601

High

635399

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

2

1

High-throughput

0.574

High

1311126

UBR1
E3 ubiquitin-protein ligase UBR1

2

1

High-throughput

0.549

High

61675

VWA8
von Willebrand factor A domain-containing protein 8

1

2

High-throughput

0.536

High

322341

GLSK
Glutaminase kidney isoform, mitochondrial

1

1

High-throughput

0.536

High

425859

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

1

High-throughput

0.536

High

725676

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

2

High-throughput

0.536

High

856423

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.536

High

1138909

SYLM
Leucine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

1194771

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

1

1

High-throughput

0.536

High

1194864

PPCEL
Prolyl endopeptidase-like

1

1

High-throughput

0.536

High

1244602

SYDM
Aspartate--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

1349954

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

1

1

High-throughput

0.536

High

1386093

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

1

High-throughput

0.536

High

1401779

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

1

High-throughput

0.536

High

166712

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.513

High

223913

NDUA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

0

High-throughput

0.513

High

271113

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

296169

GATB
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

1

0

High-throughput

0.513

High

301997

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.513

High

333727

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

High-throughput

0.513

High

425973

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.513

High

575216

IDE
Insulin-degrading enzyme

1

0

High-throughput

0.513

High

653651

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.513

High

716144

AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

846033

CACP
Carnitine O-acetyltransferase

1

0

High-throughput

0.513

High

852071

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.513

High

869260

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

914795

RM12
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.513

High

1207179

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1215644

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.513

High

1242650

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1272329

NDUF7
Protein arginine methyltransferase NDUFAF7, mitochondrial

1

0

High-throughput

0.513

High

1388306

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.513

High

1388450

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.513

High

1389032

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1403211

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

1

0

High-throughput

0.513

High

1407334

MIPEP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.513

High

1410888

MGME1
Mitochondrial genome maintenance exonuclease 1

1

0

High-throughput

0.513

High

1435825

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.513

High

1450351

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.513

High

1450542

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.513

High

1451684

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.513

High

1460232

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.513

High

1460233

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1460234

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

0

High-throughput

0.513

High

1460235

PUS1
Pseudouridylate synthase 1 homolog

1

0

High-throughput

0.513

High

190514

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.489

High

207891

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

1

High-throughput

0.489

High

1212626

HECD3
E3 ubiquitin-protein ligase HECTD3

1

4

High-throughput

0.489

High

1220871

RN123
E3 ubiquitin-protein ligase RNF123

1

3

High-throughput

0.489

High

1250534

RBP10
Ran-binding protein 10

1

4

High-throughput

0.489

High

1272758

MAEA
E3 ubiquitin-protein transferase MAEA

1

3

High-throughput

0.489

High

1307948

ARMC8
Armadillo repeat-containing protein 8

1

1

High-throughput

0.489

High

1436203

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

2

High-throughput

0.489

High

1451497

GID8
Glucose-induced degradation protein 8 homolog

1

3

High-throughput

0.489

High

1433751

MTG2
Mitochondrial ribosome-associated GTPase 2

1

6

High-throughput

0.479

High

508794

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.457

High

799556

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.437

High

913821

ZN131
Zinc finger protein 131

1

3

High-throughput

0.437

High

1434172

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

1459219

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

261977

RNH1
Ribonuclease H1

1

0

High-throughput

0.426

High

554858

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

0

High-throughput

0.426

High

1054663

PSME1
Proteasome activator complex subunit 1

1

1

High-throughput

0.407

High

1114589

CUL3
Cullin-3

1

4

High-throughput

0.407

High

1311187

UBR2
E3 ubiquitin-protein ligase UBR2

1

1

High-throughput

0.407

High

1391833

AURKB
Aurora kinase B

1

2

High-throughput

0.407

High

1358879

KBTB7
Kelch repeat and BTB domain-containing protein 7

4

0

Small-scale

0.358

High

967367

TSN5
Tetraspanin-5

3

0

High-throughput

0.347

High

1110586

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

3

0

High-throughput

0.345

High

1436387

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.328

High

391515

FRIL
Ferritin light chain

2

0

High-throughput

0.313

High

224525

PI15
Peptidase inhibitor 15

1

0

High-throughput

0.279

Low

483656

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.279

Low

562660

RINI
Ribonuclease inhibitor

1

0

High-throughput

0.279

Low

1013352

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

1309321

GID4
Glucose-induced degradation protein 4 homolog

1

0

High-throughput

0.279

Low

1388511

ZMY19
Zinc finger MYND domain-containing protein 19

1

0

High-throughput

0.279

Low

1399072

TMM74
Transmembrane protein 74

1

0

High-throughput

0.279

Low

1412796

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.279

Low

1460231

MKLN1
Muskelin

1

0

High-throughput

0.279

Low

58963

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low

239245

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.232

Low

977168

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.232

Low

1199956

P5CR3
Pyrroline-5-carboxylate reductase 3

1

0

High-throughput

0.232

Low

1386842

KCD12
BTB/POZ domain-containing protein KCTD12

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025