Protein: HERC1
Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619)

Gene: HERC1
Organism: Homo sapiens
Interactions: 137
UniProt ID: Q15751

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1078029

WDFY3
WD repeat and FYVE domain-containing protein 3

2

9

High-throughput

0.811

High

475811

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

High-throughput

0.778

High

886520

RAB15
Ras-related protein Rab-15

1

3

High-throughput

0.691

High

1078069

AKT3
RAC-gamma serine/threonine-protein kinase

1

20

High-throughput

0.691

High

1078038

SSH3
Protein phosphatase Slingshot homolog 3

3

1

High-throughput

0.667

High

1078046

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.656

High

895797

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.647

High

919733

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

High-throughput

0.647

High

932519

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

High-throughput

0.647

High

1077997

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

16

Small-scale

0.647

High

1077999

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

20

Small-scale

0.647

High

1078044

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

17

High-throughput

0.647

High

1078007

TFDP3
Transcription factor Dp family member 3

3

0

High-throughput

0.638

High

822035

KC1A
Casein kinase I isoform alpha

2

5

High-throughput

0.628

High

825894

FMO5
Flavin-containing monooxygenase 5

2

1

High-throughput

0.628

High

1078011

IFT1B
Interferon-induced protein with tetratricopeptide repeats 1B

2

13

High-throughput

0.628

High

1078015

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

2

13

High-throughput

0.628

High

1078041

RPGF5
Rap guanine nucleotide exchange factor 5

2

4

High-throughput

0.628

High

1078061

SMOX
Spermine oxidase

2

1

High-throughput

0.628

High

1078063

RABX5
Rab5 GDP/GTP exchange factor

2

1

High-throughput

0.628

High

1078026

DHX40
Probable ATP-dependent RNA helicase DHX40

1

7

High-throughput

0.618

High

148866

CTRO
Citron Rho-interacting kinase

1

18

High-throughput

0.618

High

227556

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

319851

HERC2
E3 ubiquitin-protein ligase HERC2

1

17

High-throughput

0.618

High

915700

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1078013

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.618

High

1078017

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.618

High

1078059

ANLN
Anillin

1

3

High-throughput

0.618

High

1078066

UBP18
Ubl carboxyl-terminal hydrolase 18

1

17

High-throughput

0.618

High

1078068

DYN3
Dynamin-3

1

3

High-throughput

0.618

High

1078071

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

12

Small-scale

0.618

High

1044904

RAPSN
43 kDa receptor-associated protein of the synapse

2

7

High-throughput

0.611

High

671456

ECHM
Enoyl-CoA hydratase, mitochondrial

3

11

High-throughput

0.609

High

1078021

MORC1
MORC family CW-type zinc finger protein 1

3

2

High-throughput

0.609

High

313111

GCNT3
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

2

0

High-throughput

0.602

High

1078023

VPS36
Vacuolar protein-sorting-associated protein 36

2

0

High-throughput

0.602

High

1078039

TP4AP
Short transient receptor potential channel 4-associated protein

2

0

High-throughput

0.602

High

982043

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

67758

ZBBX
Zinc finger B-box domain-containing protein 1

2

1

High-throughput

0.574

High

1078028

DRC2
Dynein regulatory complex subunit 2

2

1

High-throughput

0.574

High

1078032

ZN610
Zinc finger protein 610

2

1

High-throughput

0.574

High

1078035

ZN555
Zinc finger protein 555

2

2

High-throughput

0.574

High

1078064

ZN223
Zinc finger protein 223

2

2

High-throughput

0.574

High

1078072

NGN3
Neurogenin-3

2

3

High-throughput

0.574

High

960814

CLH1
Clathrin heavy chain 1

1

7

Small-scale

0.573

High

374287

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.561

High

231531

KIF1B
Kinesin-like protein KIF1B

1

9

High-throughput

0.553

High

318141

DIRA3
GTP-binding protein Di-Ras3

1

4

High-throughput

0.553

High

156615

PPE1
Serine/threonine-protein phosphatase with EF-hands 1

1

8

High-throughput

0.536

High

708655

MCM5
DNA replication licensing factor MCM5

1

7

High-throughput

0.536

High

1023165

FLII
Protein flightless-1 homolog

1

7

High-throughput

0.536

High

1078016

TLCD5
TLC domain-containing protein 5

1

2

High-throughput

0.536

High

1078022

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

4

High-throughput

0.536

High

1078047

EFMT3
EEF1A lysine methyltransferase 3

1

7

High-throughput

0.536

High

1078048

PABP5
Polyadenylate-binding protein 5

1

11

High-throughput

0.536

High

1078054

AFG2B
ATPase family gene 2 protein homolog B

1

7

High-throughput

0.536

High

1078056

UBXN6
UBX domain-containing protein 6

1

3

High-throughput

0.536

High

1078057

SENP3
Sentrin-specific protease 3

1

6

High-throughput

0.536

High

1078062

KLH14
Kelch-like protein 14

1

1

High-throughput

0.536

High

1078067

SNX6
Sorting nexin-6

1

4

High-throughput

0.536

High

537915

KPYM
Pyruvate kinase PKM

1

7

Small-scale

0.527

High

654363

CALX
Calnexin

1

6

High-throughput

0.515

High

1078020

TTC6
Tetratricopeptide repeat protein 6

1

11

High-throughput

0.514

High

195909

TTI1
TELO2-interacting protein 1 homolog

1

0

High-throughput

0.513

High

596550

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.513

High

1078000

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.513

High

1078008

SPDYC
Speedy protein C

1

0

High-throughput

0.513

High

1078009

ATAT
Alpha-tubulin N-acetyltransferase 1

1

0

High-throughput

0.513

High

1078012

IKBP1
Interleukin-1 receptor-associated kinase 1-binding protein 1

1

0

High-throughput

0.513

High

1078025

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.513

High

1078034

CC020
Uncharacterized protein C3orf20

1

0

High-throughput

0.513

High

1078040

CHAC2
Glutathione-specific gamma-glutamylcyclotransferase 2

1

0

High-throughput

0.513

High

818806

SOX9
Transcription factor SOX-9

1

17

Small-scale

0.512

High

337485

ABL1
Tyrosine-protein kinase ABL1

1

16

Small-scale

0.501

High

485066

GLI2
Zinc finger protein GLI2

1

7

High-throughput

0.500

High

398883

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.493

High

47928

IFT56
Intraflagellar transport protein 56

1

1

High-throughput

0.489

High

63923

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

1

High-throughput

0.489

High

258275

PX11A
Peroxisomal membrane protein 11A

1

1

High-throughput

0.489

High

855866

ZN136
Zinc finger protein 136

1

4

High-throughput

0.489

High

1078003

INF2
Inverted formin-2

1

7

High-throughput

0.489

High

1078018

ATS13
A disintegrin and metalloproteinase with thrombospondin motifs 13

1

1

High-throughput

0.489

High

1078031

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1078033

C2C4A
C2 calcium-dependent domain-containing protein 4A

1

1

High-throughput

0.489

High

1078037

ZN563
Zinc finger protein 563

1

3

High-throughput

0.489

High

1078050

PPM1M
Protein phosphatase 1M

1

2

High-throughput

0.489

High

1078051

NPAS1
Neuronal PAS domain-containing protein 1

1

5

High-throughput

0.489

High

1078070

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

2

High-throughput

0.489

High

70450

R10B2
Radial spoke head 10 homolog B2

1

6

High-throughput

0.479

High

130906

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

18

High-throughput

0.479

High

154967

NDC80
Kinetochore protein NDC80 homolog

1

5

High-throughput

0.479

High

210026

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

308742

KI20A
Kinesin-like protein KIF20A

1

17

High-throughput

0.479

High

327740

TTLL1
Polyglutamylase complex subunit TTLL1

1

1

High-throughput

0.479

High

338476

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

573712

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

6

High-throughput

0.479

High

649526

RL10
Large ribosomal subunit protein uL16

1

4

High-throughput

0.479

High

718513

NOS2
Nitric oxide synthase, inducible

1

2

High-throughput

0.479

High

749529

BRCA1
Breast cancer type 1 susceptibility protein

1

8

High-throughput

0.479

High

835064

TSC2
Tuberin

1

5

Small-scale

0.479

High

885528

MLF1
Myeloid leukemia factor 1

1

1

High-throughput

0.479

High

886113

H2B1D
Histone H2B type 1-D

1

12

High-throughput

0.479

High

950497

ARF1
ADP-ribosylation factor 1

1

6

Small-scale

0.479

High

998752

EP300
Histone acetyltransferase p300

1

11

Small-scale

0.479

High

1041654

CUL3
Cullin-3

1

19

High-throughput

0.479

High

1066168

KIF14
Kinesin-like protein KIF14

1

11

High-throughput

0.479

High

1078005

RHG29
Rho GTPase-activating protein 29

1

9

High-throughput

0.479

High

1078024

DYR2
Dihydrofolate reductase 2, mitochondrial

1

2

High-throughput

0.479

High

1078043

FGF11
Fibroblast growth factor 11

1

6

High-throughput

0.479

High

1078052

H2B1L
Histone H2B type 1-L

1

11

High-throughput

0.479

High

1078060

PXMP2
Peroxisomal membrane protein 2

1

2

High-throughput

0.479

High

124298

DFFA
DNA fragmentation factor subunit alpha

1

0

High-throughput

0.458

High

484373

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.458

High

1078036

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1078065

AKP8L
A-kinase anchor protein 8-like

1

3

High-throughput

0.445

High

402067

JUN
Transcription factor Jun

1

8

High-throughput

0.437

High

552822

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.437

High

651304

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.437

High

1078042

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

2

High-throughput

0.437

High

1078058

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

2

High-throughput

0.437

High

1077998

BAK
Bcl-2 homologous antagonist/killer

1

5

Small-scale

0.408

High

321089

PTBP3
Polypyrimidine tract-binding protein 3

1

10

High-throughput

0.407

High

1078014

TBC3G
TBC1 domain family member 3G

1

2

High-throughput

0.407

High

1078001

TIGD6
Tigger transposable element-derived protein 6

2

0

High-throughput

0.328

High

1078019

ZN571
Zinc finger protein 571

2

0

High-throughput

0.328

High

1078030

CA087
Uncharacterized protein C1orf87

2

0

High-throughput

0.328

High

272351

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.279

Low

1078004

CMAP2
Ciliary microtubule-associated protein 2

1

0

High-throughput

0.279

Low

1078006

VWA2
von Willebrand factor A domain-containing protein 2

1

0

High-throughput

0.279

Low

1078010

F120S
Uncharacterized protein FAM120AOS

1

0

High-throughput

0.279

Low

1078027

IQCF2
IQ domain-containing protein F2

1

0

High-throughput

0.279

Low

1078045

UCN3
Urocortin-3

1

0

High-throughput

0.279

Low

1078049

HES6
Transcription cofactor HES-6

1

0

High-throughput

0.279

Low

1078053

GDAH
Guanidino acid hydrolase, mitochondrial

1

0

High-throughput

0.279

Low

1078055

FND11
Fibronectin type III domain-containing protein 11

1

0

High-throughput

0.279

Low

1078002

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024