Protein: WIPI4
WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45)

Gene: WIPI4, WDR45
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q9Y484

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000407 - phagophore assembly site
GO:0000422 - autophagy of mitochondrion
GO:0000425 - pexophagy
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1385181

ATG2B
Autophagy-related protein 2 homolog B

4

10

High-throughput

0.702

High

1180339

ATG2A
Autophagy-related protein 2 homolog A

4

10

Small-scale

0.698

High

1458588

SPAST
Spastin

2

15

High-throughput

0.628

High

791042

TALDO
Transaldolase

2

1

High-throughput

0.611

High

1040245

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

3

12

High-throughput

0.609

High

1462472

LHX6
LIM/homeobox protein Lhx6

3

2

High-throughput

0.609

High

259187

DNJA2
DnaJ homolog subfamily A member 2

2

16

High-throughput

0.601

High

1227766

A16L1
Autophagy-related protein 16-1

1

19

High-throughput

0.575

High

1491339

WIPI4
WD repeat domain phosphoinositide-interacting protein 4

1

19

High-throughput

0.575

High

1387302

HDA11
Histone deacetylase 11

2

20

High-throughput

0.574

High

572487

DRD2
D(2) dopamine receptor

1

2

High-throughput

0.536

High

844127

HD
Huntingtin

1

3

High-throughput

0.536

High

423522

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

1491330

SALL2
Sal-like protein 2

1

2

High-throughput

0.489

High

173603

XPO1
Exportin-1

1

20

High-throughput

0.479

High

483275

CLCA
Clathrin light chain A

1

1

High-throughput

0.479

High

552734

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.479

High

581389

RAC2
Ras-related C3 botulinum toxin substrate 2

1

4

High-throughput

0.479

High

583037

EZRI
Ezrin

1

3

High-throughput

0.479

High

702066

TMOD1
Tropomodulin-1

1

3

High-throughput

0.479

High

877050

KC1A
Casein kinase I isoform alpha

1

10

Small-scale

0.479

High

878588

PAXI
Paxillin

1

5

High-throughput

0.479

High

901704

RAB7A
Ras-related protein Rab-7a

1

8

High-throughput

0.479

High

956555

RAB2A
Ras-related protein Rab-2A

1

8

High-throughput

0.479

High

975338

ARF6
ADP-ribosylation factor 6

1

5

High-throughput

0.479

High

1028461

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

High-throughput

0.479

High

1114735

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1197139

AMOT
Angiomotin

1

12

High-throughput

0.479

High

1363905

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

3

High-throughput

0.479

High

1403097

CEP89
Centrosomal protein of 89 kDa

1

20

High-throughput

0.479

High

1428437

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

5

High-throughput

0.479

High

1434316

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.479

High

1438148

ZFYV1
Zinc finger FYVE domain-containing protein 1

1

5

Small-scale

0.479

High

1438263

RHOF
Rho-related GTP-binding protein RhoF

1

5

High-throughput

0.479

High

926250

ICLN
Methylosome subunit pICln

1

0

Small-scale

0.458

High

47889

A0AUL9
ATG2A protein

1

9

High-throughput

0.445

High

271588

ATG13
Autophagy-related protein 13

1

2

High-throughput

0.445

High

451467

NFM
Neurofilament medium polypeptide

1

10

High-throughput

0.437

High

631038

RAB4A
Ras-related protein Rab-4A

1

7

High-throughput

0.437

High

1334202

POC1A
POC1 centriolar protein homolog A

1

19

High-throughput

0.437

High

1414920

DUS26
Dual specificity protein phosphatase 26

1

2

High-throughput

0.437

High

1460326

XPO7
Exportin-7

1

20

High-throughput

0.437

High

281485

MSPD3
Motile sperm domain-containing protein 3

1

0

High-throughput

0.279

Low

1178924

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1235440

LCN8
Epididymal-specific lipocalin-8

1

0

High-throughput

0.279

Low

1248937

ARSK
Arylsulfatase K

1

0

High-throughput

0.279

Low

1438344

PLRKT
Plasminogen receptor

1

0

High-throughput

0.279

Low

1439681

XAGE1
X antigen family member 1

1

0

High-throughput

0.279

Low

1452983

CISD1
CDGSH iron-sulfur domain-containing protein 1

1

0

High-throughput

0.279

Low

1365540

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025