Protein: ARF
Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p14ARF)

Gene: ARF, CDKN2A
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q8N726

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000422 - autophagy of mitochondrion
GO:0002039 - p53 binding
GO:0003677 - DNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1028285

MDM2
E3 ubiquitin-protein ligase Mdm2

7

1

Small-scale

0.737

High

414210

P53
Cellular tumor antigen p53

4

1

Small-scale

0.666

High

447222

NPM
Nucleophosmin

3

1

Small-scale

0.633

High

1280339

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

1

Small-scale

0.612

High

1129343

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

2

Small-scale

0.578

High

1330264

CARF
CDKN2A-interacting protein

2

1

Small-scale

0.576

High

1330261

ZN420
Zinc finger protein 420

1

0

Small-scale

0.561

High

465004

SP1
Transcription factor Sp1

1

2

Small-scale

0.561

High

1330267

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.538

High

406393

MYCN
N-myc proto-oncogene protein

1

1

Small-scale

0.515

High

613101

EGR1
Early growth response protein 1

1

2

Small-scale

0.515

High

1029114

E2F1
Transcription factor E2F1

1

0

Small-scale

0.493

High

1058142

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.493

High

786725

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

3

High-throughput

0.479

High

968380

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

3

High-throughput

0.479

High

1102599

MTA1
Metastasis-associated protein MTA1

1

1

Small-scale

0.479

High

884365

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

Small-scale

0.458

High

1006553

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.445

High

1287857

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

1

High-throughput

0.445

High

1330260

HIPK4
Homeodomain-interacting protein kinase 4

1

1

High-throughput

0.445

High

1330263

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.445

High

1330269

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

1

High-throughput

0.445

High

1330272

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

1

High-throughput

0.445

High

254387

CC14B
Dual specificity protein phosphatase CDC14B

1

0

High-throughput

0.438

High

282989

FRAT2
GSK-3-binding protein FRAT2

1

0

High-throughput

0.438

High

374766

RASH
GTPase HRas

1

0

High-throughput

0.438

High

376874

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.438

High

421194

ALDOB
Fructose-bisphosphate aldolase B

1

0

High-throughput

0.438

High

635733

RASA1
Ras GTPase-activating protein 1

1

0

High-throughput

0.438

High

702017

TMOD1
Tropomodulin-1

1

0

High-throughput

0.438

High

951266

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.438

High

1038327

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

0

High-throughput

0.438

High

1120073

BAAT
Bile acid-CoA:amino acid N-acyltransferase

1

0

High-throughput

0.438

High

1120134

CYLC2
Cylicin-2

1

0

High-throughput

0.438

High

1160822

MAPK3
MAP kinase-activated protein kinase 3

1

0

High-throughput

0.438

High

1232368

SFRP4
Secreted frizzled-related protein 4

1

0

High-throughput

0.438

High

1329531

AMPO
Aminopeptidase O

1

0

High-throughput

0.438

High

123771

MYO1C
Unconventional myosin-Ic

1

0

High-throughput

0.426

High

244988

KATIP
Katanin-interacting protein

1

0

High-throughput

0.426

High

643931

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.426

High

856802

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.426

High

1112917

CUL2
Cullin-2

1

0

High-throughput

0.426

High

1130342

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1140185

ARHG6
Rho guanine nucleotide exchange factor 6

1

0

High-throughput

0.426

High

1161152

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.426

High

1330262

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.426

High

1330268

CD11A
Cyclin-dependent kinase 11A

1

0

High-throughput

0.426

High

1330271

S4A7
Sodium bicarbonate cotransporter 3

1

1

High-throughput

0.407

High

261637

CATL2
Cathepsin L2

1

0

High-throughput

0.238

Low

1312523

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

0

High-throughput

0.238

Low

1315400

TEFF1
Tomoregulin-1

1

0

High-throughput

0.238

Low

1330265

CC180
Coiled-coil domain-containing protein 180

1

0

High-throughput

0.238

Low

190437

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.232

Low

838945

RHG25
Rho GTPase-activating protein 25

1

0

High-throughput

0.232

Low

844945

EAA2
Excitatory amino acid transporter 2

1

0

High-throughput

0.232

Low

1239008

NIPA3
Magnesium transporter NIPA3

1

0

High-throughput

0.232

Low

1330266

CFA97
Cilia- and flagella-associated protein 97

1

0

High-throughput

0.232

Low

1330270

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025