Protein: TIM21
Mitochondrial import inner membrane translocase subunit Tim21 (TIM21-like protein, mitochondrial)

Gene: TIM21, TIMM21
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q9BVV7

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005744 - TIM23 mitochondrial import inner membrane translocase complex
GO:0005758 - mitochondrial intermembrane space
GO:0006886 - intracellular protein transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1259474

TBA1A
Tubulin alpha-1A chain

2

0

High-throughput

0.547

High

411033

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

1

High-throughput

0.533

High

168118

TIM23
Mitochondrial import inner membrane translocase subunit Tim23

1

1

Small-scale

0.500

High

124648

EYA2
Protein phosphatase EYA2

1

1

High-throughput

0.479

High

1397643

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

1403409

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

137805

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

275097

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

959241

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

1359182

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.458

High

1389883

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.458

High

1415761

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

1415765

BRD8
Bromodomain-containing protein 8

1

0

High-throughput

0.458

High

1286893

TM11B
Transmembrane protease serine 11B

1

1

High-throughput

0.437

High

1405010

EYA3
Protein phosphatase EYA3

1

1

High-throughput

0.437

High

1415769

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.437

High

328397

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

0

Small-scale

0.426

High

360290

COX1
Cytochrome c oxidase subunit 1

1

0

Small-scale

0.426

High

485890

COX6C
Cytochrome c oxidase subunit 6C

1

0

Small-scale

0.426

High

560079

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

Small-scale

0.426

High

1123408

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.426

High

1192095

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

Small-scale

0.426

High

1415764

COA1
Cytochrome c oxidase assembly factor 1 homolog

1

0

Small-scale

0.426

High

1415773

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

1

0

Small-scale

0.426

High

211174

CTR4
Cationic amino acid transporter 4

1

2

High-throughput

0.407

High

722603

CTR1
High affinity cationic amino acid transporter 1

1

2

High-throughput

0.407

High

1323761

S39AB
Zinc transporter ZIP11

1

2

High-throughput

0.407

High

1348632

S7A14
Solute carrier family 7 member 14

1

2

High-throughput

0.407

High

1363433

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.407

High

1415763

S39A8
Metal cation symporter ZIP8

1

2

High-throughput

0.407

High

1415771

UBQL2
Ubiquilin-2

2

0

High-throughput

0.316

High

1355891

GRK7
Rhodopsin kinase GRK7

1

0

High-throughput

0.279

Low

1415772

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.279

Low

1371106

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.269

Low

710457

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.261

Low

162966

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.251

Low

227658

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

294278

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

343277

ERR2
Steroid hormone receptor ERR2

1

0

High-throughput

0.249

Low

415836

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.249

Low

455862

H10
Histone H1.0

1

0

High-throughput

0.249

Low

589586

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

696397

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

831358

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

1005051

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1100326

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

1163868

DUS6
Dual specificity protein phosphatase 6

1

0

High-throughput

0.249

Low

1249182

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1250136

ITIH6
Inter-alpha-trypsin inhibitor heavy chain H6

1

0

High-throughput

0.249

Low

1391738

AURKB
Aurora kinase B

1

0

High-throughput

0.249

Low

1397393

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1398999

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

1415762

MTMRC
Myotubularin-related protein 12

1

0

High-throughput

0.249

Low

1415766

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1415767

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

1415768

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

1415770

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

256136

S19A2
Thiamine transporter 1

1

0

High-throughput

0.232

Low

1034523

TAGL
Transgelin

1

0

High-throughput

0.232

Low

1239043

NIPA3
Magnesium transporter NIPA3

1

0

High-throughput

0.232

Low

1271264

SV2B
Synaptic vesicle glycoprotein 2B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025