Protein: COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (Coiled-coil domain-containing protein 56) (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa)

Gene: COA3
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q9Y2R0

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0033617 - mitochondrial cytochrome c oxidase assembly
GO:0070131 - positive regulation of mitochondrial translation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

360297

COX1
Cytochrome c oxidase subunit 1

3

0

Small-scale

0.634

High

560132

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

3

1

Small-scale

0.633

High

360492

COX2
Cytochrome c oxidase subunit 2

3

0

Small-scale

0.606

High

528531

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

2

0

High-throughput

0.585

High

1149649

SURF1
Surfeit locus protein 1

2

0

Small-scale

0.585

High

1281406

COXM1
COX assembly mitochondrial protein homolog

2

0

Small-scale

0.576

High

1394065

COX14
Cytochrome c oxidase assembly protein COX14

2

0

Small-scale

0.576

High

485909

COX6C
Cytochrome c oxidase subunit 6C

2

0

Small-scale

0.547

High

634199

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

2

0

Small-scale

0.547

High

1414123

TMM70
Transmembrane protein 70, mitochondrial

2

0

Small-scale

0.547

High

624687

SL9A1
Sodium/hydrogen exchanger 1

1

0

High-throughput

0.513

High

1396079

COX42
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

1

1

Small-scale

0.479

High

137849

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

275136

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

360732

COX3
Cytochrome c oxidase subunit 3

1

0

Small-scale

0.458

High

842033

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

Small-scale

0.458

High

882957

EFTU
Elongation factor Tu, mitochondrial

1

0

Small-scale

0.458

High

891068

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

Small-scale

0.458

High

1163565

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

Small-scale

0.458

High

1361709

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

1

0

High-throughput

0.458

High

1389940

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.458

High

1420436

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

1428771

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

Small-scale

0.458

High

1450605

ATD3A
ATPase family AAA domain-containing protein 3A

1

0

Small-scale

0.458

High

1024499

S25A3
Solute carrier family 25 member 3

1

1

Small-scale

0.445

High

1040242

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

1

Small-scale

0.445

High

1242329

SFXN4
Sideroflexin-4

1

2

Small-scale

0.445

High

1436976

SFXN1
Sideroflexin-1

1

2

Small-scale

0.445

High

49480

TM223
Transmembrane protein 223

1

0

Small-scale

0.426

High

292255

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

Small-scale

0.426

High

333608

NDUC2
NADH dehydrogenase [ubiquinone] 1 subunit C2

1

0

Small-scale

0.426

High

1035485

CX6A2
Cytochrome c oxidase subunit 6A2, mitochondrial

1

0

Small-scale

0.426

High

1181000

Q305V2
NADH-ubiquinone oxidoreductase chain 2

1

0

Small-scale

0.426

High

1200415

TM177
Transmembrane protein 177

1

0

Small-scale

0.426

High

1201340

OCAD2
OCIA domain-containing protein 2

1

0

Small-scale

0.426

High

1270677

COX15
Heme A synthase COX15

1

0

Small-scale

0.426

High

1278151

MAVS
Mitochondrial antiviral-signaling protein

1

0

Small-scale

0.426

High

1326246

PNKD
Probable thioesterase PNKD

1

0

Small-scale

0.426

High

1327686

SIM20
Small integral membrane protein 20

1

0

Small-scale

0.426

High

1333820

RDH13
Retinol dehydrogenase 13

1

0

Small-scale

0.426

High

1388611

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

Small-scale

0.426

High

1410347

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

Small-scale

0.426

High

1412481

TACO1
Translational activator of cytochrome c oxidase 1

1

0

Small-scale

0.426

High

1415773

TIM21
Mitochondrial import inner membrane translocase subunit Tim21

1

0

Small-scale

0.426

High

1429121

COA1
Cytochrome c oxidase assembly factor 1 homolog

1

0

Small-scale

0.426

High

1446598

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

Small-scale

0.426

High

1453996

COX16
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial

1

0

Small-scale

0.426

High

1490875

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

0

Small-scale

0.426

High

1490876

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

1

0

Small-scale

0.426

High

76377

B4DRS6
Sidoreflexin

1

2

Small-scale

0.407

High

1139609

S39AE
Metal cation symporter ZIP14

1

2

High-throughput

0.407

High

1323787

S39AB
Zinc transporter ZIP11

1

2

High-throughput

0.407

High

1461548

S39AA
Zinc transporter ZIP10

1

2

High-throughput

0.407

High

626438

CXCL2
C-X-C motif chemokine 2

1

0

High-throughput

0.279

Low

814891

CUX1
Homeobox protein cut-like 1

1

0

High-throughput

0.279

Low

1432551

SNX25
Sorting nexin-25

1

0

High-throughput

0.279

Low

1460258

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.279

Low

294555

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

364062

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.249

Low

590076

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

607242

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

696913

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

769561

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1178474

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1249348

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1370480

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.249

Low

1459375

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

679299

DNJB1
DnaJ homolog subfamily B member 1

1

0

Small-scale

0.232

Low

1254202

MFSD6
Major facilitator superfamily domain-containing protein 6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025