Protein: COX1
Cytochrome c oxidase subunit 1 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide I)

Gene: COX1, MT-CO1
Organism: Homo sapiens
Interactions: 67
UniProt ID: P00395

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0004129 - cytochrome-c oxidase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

360245

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

3

1

Small-scale

0.847

High

360244

CX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial

1

2

High-throughput

0.691

High

360289

COX42
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

1

1

High-throughput

0.691

High

360281

S22A9
Organic anion transporter 7

2

0

High-throughput

0.679

High

360247

COX7C
Cytochrome c oxidase subunit 7C, mitochondrial

1

0

High-throughput

0.656

High

360250

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

0

High-throughput

0.656

High

360287

CX7B2
Cytochrome c oxidase subunit 7B2, mitochondrial

1

0

High-throughput

0.656

High

360297

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

3

0

Small-scale

0.634

High

360252

NK1R
Substance-P receptor

2

3

High-throughput

0.628

High

360239

COX2
Cytochrome c oxidase subunit 2

1

1

Small-scale

0.618

High

360251

EDNRA
Endothelin-1 receptor

2

4

High-throughput

0.611

High

360241

ASGR2
Asialoglycoprotein receptor 2

3

1

High-throughput

0.609

High

360246

QCR7
Cytochrome b-c1 complex subunit 7

2

0

High-throughput

0.585

High

360268

CX6A2
Cytochrome c oxidase subunit 6A2, mitochondrial

1

2

Small-scale

0.575

High

360257

OPRM
Mu-type opioid receptor

2

1

High-throughput

0.574

High

360258

APJ
Apelin receptor

2

2

High-throughput

0.574

High

360294

P2Y12
P2Y purinoceptor 12

2

3

High-throughput

0.558

High

360288

COX14
Cytochrome c oxidase assembly protein COX14

2

0

Small-scale

0.547

High

360248

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

1

High-throughput

0.536

High

360259

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

1

High-throughput

0.536

High

360266

RAC1
Ras-related C3 botulinum toxin substrate 1

2

2

High-throughput

0.521

High

168946

QCR8
Cytochrome b-c1 complex subunit 8

1

0

High-throughput

0.513

High

360273

RM02
Large ribosomal subunit protein uL2m

1

0

High-throughput

0.513

High

360279

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.513

High

360293

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.513

High

165881

FFAR1
Free fatty acid receptor 1

1

4

High-throughput

0.489

High

210378

MTLR
Motilin receptor

1

5

High-throughput

0.489

High

360249

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

2

High-throughput

0.489

High

360254

GRPR
Gastrin-releasing peptide receptor

1

4

High-throughput

0.489

High

360255

NTR1
Neurotensin receptor type 1

1

3

High-throughput

0.489

High

360256

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

1

High-throughput

0.489

High

360262

GLR
Glucagon receptor

1

1

High-throughput

0.489

High

360270

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

3

High-throughput

0.489

High

360276

GP141
Probable G-protein coupled receptor 141

1

4

High-throughput

0.489

High

360280

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

3

High-throughput

0.489

High

360299

GPR45
Probable G-protein coupled receptor 45

1

2

High-throughput

0.489

High

360240

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.480

High

360275

CLC4G
C-type lectin domain family 4 member G

1

1

High-throughput

0.464

High

360269

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.460

High

328342

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

0

Small-scale

0.458

High

360265

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.439

High

360298

GPR52
G-protein coupled receptor 52

1

2

High-throughput

0.437

High

360242

COX6C
Cytochrome c oxidase subunit 6C

1

0

Small-scale

0.426

High

360243

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

360277

COXM1
COX assembly mitochondrial protein homolog

1

0

Small-scale

0.426

High

360290

TIM21
Mitochondrial import inner membrane translocase subunit Tim21

1

0

Small-scale

0.426

High

360292

COA1
Cytochrome c oxidase assembly factor 1 homolog

1

0

Small-scale

0.426

High

360260

SYUA
Alpha-synuclein

1

0

Small-scale

0.391

High

360278

RETR3
Reticulophagy regulator 3

3

0

High-throughput

0.347

High

360284

UXS1
UDP-glucuronic acid decarboxylase 1

2

0

High-throughput

0.328

High

360271

KPCD1
Serine/threonine-protein kinase D1

2

0

High-throughput

0.298

High

360267

DLG4
Disks large homolog 4

1

0

High-throughput

0.282

High

71191

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

349351

TSN15
Tetraspanin-15

1

0

High-throughput

0.279

Low

360253

5HT1B
5-hydroxytryptamine receptor 1B

1

0

High-throughput

0.279

Low

360261

S15A1
Solute carrier family 15 member 1

1

0

High-throughput

0.279

Low

360274

I27RA
Interleukin-27 receptor subunit alpha

1

0

High-throughput

0.279

Low

360282

SC5A8
Sodium-coupled monocarboxylate transporter 1

1

0

High-throughput

0.279

Low

360285

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.279

Low

360286

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.279

Low

360291

CCG6
Voltage-dependent calcium channel gamma-6 subunit

1

0

High-throughput

0.279

Low

360272

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.265

Low

360263

DNLI4
DNA ligase 4

1

0

High-throughput

0.251

Low

360264

MEOX2
Homeobox protein MOX-2

1

0

Small-scale

0.251

Low

360283

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

360296

SIK3
Serine/threonine-protein kinase SIK3

1

0

High-throughput

0.249

Low

360295

UBQL1
Ubiquilin-1

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025