Protein: TERT
Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2)

Gene: TERT
Organism: Homo sapiens
Interactions: 109
UniProt ID: O14746

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0000333 - telomerase catalytic core complex
GO:0000722 - telomere maintenance via recombination
GO:0000723 - telomere maintenance
GO:0000781 - chromosome, telomeric region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

162895

HS90A
Heat shock protein HSP 90-alpha

6

1

Small-scale

0.725

High

162879

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.676

High

162957

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

3

1

Small-scale

0.674

High

162941

TEBP
Prostaglandin E synthase 3

4

0

Small-scale

0.658

High

162911

AKT1
RAC-alpha serine/threonine-protein kinase

3

2

Small-scale

0.656

High

162935

MDM2
E3 ubiquitin-protein ligase Mdm2

3

0

Small-scale

0.654

High

162926

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

2

2

Small-scale

0.634

High

162900

XRCC5
X-ray repair cross-complementing protein 5

2

3

Small-scale

0.624

High

162947

EST1A
Telomerase-binding protein EST1A

2

1

Small-scale

0.624

High

162880

TPP1
Tripeptidyl-peptidase 1

2

0

Small-scale

0.619

High

162961

CIB1
Calcium and integrin-binding protein 1

2

0

Small-scale

0.609

High

162884

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

2

1

Small-scale

0.601

High

162887

MYC
Myc proto-oncogene protein

2

1

Small-scale

0.595

High

162984

RUVB1
RuvB-like 1

1

5

Small-scale

0.586

High

162985

DCAF1
DDB1- and CUL4-associated factor 1

2

1

Small-scale

0.584

High

162882

FOXO3
Forkhead box protein O3

1

1

Small-scale

0.561

High

162899

XRCC6
X-ray repair cross-complementing protein 6

1

3

Small-scale

0.561

High

162904

NUCL
Nucleolin

1

1

Small-scale

0.561

High

162981

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

1

Small-scale

0.561

High

162962

TEP1
Telomerase protein component 1

2

0

Small-scale

0.559

High

162976

MKRN1
E3 ubiquitin-protein ligase makorin-1

2

0

Small-scale

0.559

High

162951

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

0

Small-scale

0.537

High

162958

MCRS1
Microspherule protein 1

1

0

Small-scale

0.537

High

162980

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

Small-scale

0.537

High

162965

GNL3
Guanine nucleotide-binding protein-like 3

1

1

Small-scale

0.536

High

162969

KPCD2
Serine/threonine-protein kinase D2

1

2

High-throughput

0.536

High

162983

RUVB2
RuvB-like 2

1

5

Small-scale

0.536

High

162929

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

0

Small-scale

0.529

High

162908

1433T
14-3-3 protein theta

1

1

Small-scale

0.527

High

162913

CTNB1
Catenin beta-1

1

6

Small-scale

0.515

High

162893

NPM
Nucleophosmin

1

0

Small-scale

0.513

High

162970

PIP30
PSME3-interacting protein

1

0

High-throughput

0.513

High

162909

PML
Protein PML

1

0

Small-scale

0.512

High

162952

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.512

High

162888

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.501

High

162897

CDK4
Cyclin-dependent kinase 4

1

1

High-throughput

0.501

High

162901

BRAF
Serine/threonine-protein kinase B-raf

1

1

High-throughput

0.501

High

162902

PGFRA
Platelet-derived growth factor receptor alpha

1

1

High-throughput

0.501

High

162903

KPCA
Protein kinase C alpha type

1

1

Small-scale

0.501

High

162916

SOX3
Transcription factor SOX-3

1

1

High-throughput

0.501

High

162919

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

1

High-throughput

0.501

High

162920

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

1

High-throughput

0.501

High

162921

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

2

High-throughput

0.501

High

162928

TERF1
Telomeric repeat-binding factor 1

1

2

Small-scale

0.501

High

162934

CDK6
Cyclin-dependent kinase 6

1

1

High-throughput

0.501

High

162936

SOX4
Transcription factor SOX-4

1

1

High-throughput

0.501

High

162938

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

2

High-throughput

0.501

High

162960

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

1

High-throughput

0.501

High

162972

RASF1
Ras association domain-containing protein 1

1

2

High-throughput

0.501

High

162925

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

2

Small-scale

0.500

High

162881

SR140
U2 snRNP-associated SURP motif-containing protein

1

1

Small-scale

0.481

High

162898

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.481

High

162931

1433Z
14-3-3 protein zeta/delta

1

1

Small-scale

0.481

High

162896

MET
Hepatocyte growth factor receptor

1

0

High-throughput

0.480

High

162905

FGFR4
Fibroblast growth factor receptor 4

1

0

High-throughput

0.480

High

162907

CCNE1
G1/S-specific cyclin-E1

1

0

High-throughput

0.480

High

162910

CCND2
G1/S-specific cyclin-D2

1

0

High-throughput

0.480

High

162912

HSP74
Heat shock 70 kDa protein 4

1

0

Small-scale

0.480

High

162914

MERL
Merlin

1

0

High-throughput

0.480

High

162939

GRM1
Metabotropic glutamate receptor 1

1

0

High-throughput

0.480

High

162940

BECN1
Beclin-1

1

0

High-throughput

0.480

High

162942

PTPA
Serine/threonine-protein phosphatase 2A activator

1

0

Small-scale

0.480

High

162943

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.480

High

162944

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.480

High

162954

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

High-throughput

0.480

High

162967

NSD3
Histone-lysine N-methyltransferase NSD3

1

0

High-throughput

0.480

High

162968

GLIS2
Zinc finger protein GLIS2

1

0

High-throughput

0.480

High

162977

DACH1
Dachshund homolog 1

1

0

High-throughput

0.480

High

162978

CBLC
E3 ubiquitin-protein ligase CBL-C

1

0

High-throughput

0.480

High

162979

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.480

High

162950

SMRC2
SWI/SNF complex subunit SMARCC2

1

0

Small-scale

0.479

High

162955

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

0

Small-scale

0.479

High

162906

KS6B1
Ribosomal protein S6 kinase beta-1

1

2

Small-scale

0.479

High

162974

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

1

Small-scale

0.479

High

71416

P20L1
PHD finger protein 20-like protein 1

1

0

Small-scale

0.460

High

162889

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

0

Small-scale

0.460

High

162890

AGAL
Alpha-galactosidase A

1

0

Small-scale

0.460

High

162891

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

0

Small-scale

0.460

High

162892

ENOA
Alpha-enolase

1

0

Small-scale

0.460

High

162894

ANXA2
Annexin A2

1

0

Small-scale

0.460

High

162915

TGFR2
TGF-beta receptor type-2

1

0

Small-scale

0.460

High

162918

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

0

Small-scale

0.460

High

162922

IREB2
Iron-responsive element-binding protein 2

1

0

Small-scale

0.460

High

162923

TCPE
T-complex protein 1 subunit epsilon

1

0

Small-scale

0.460

High

162930

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

Small-scale

0.460

High

162932

DYL1
Dynein light chain 1, cytoplasmic

1

0

Small-scale

0.460

High

162946

STEA4
Metalloreductase STEAP4

1

0

Small-scale

0.460

High

162948

DDX51
ATP-dependent RNA helicase DDX51

1

0

Small-scale

0.460

High

162949

SERB1
SERPINE1 mRNA-binding protein 1

1

0

Small-scale

0.460

High

162959

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

Small-scale

0.460

High

162963

FAP24
Fanconi anemia core complex-associated protein 24

1

0

Small-scale

0.460

High

162982

XCT
Cystine/glutamate transporter

1

0

Small-scale

0.460

High

162883

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

162886

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

Small-scale

0.458

High

162917

MTOR
Serine/threonine-protein kinase mTOR

1

0

Small-scale

0.458

High

162924

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

162927

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

162937

FOXM1
Forkhead box protein M1

1

0

Small-scale

0.458

High

162945

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.458

High

162953

RL3L
Ribosomal protein uL3-like

1

0

High-throughput

0.458

High

162956

ACD
Adrenocortical dysplasia protein homolog

1

0

Small-scale

0.458

High

162971

NAT10
RNA cytidine acetyltransferase

1

0

Small-scale

0.458

High

162973

POTE1
Protection of telomeres protein 1

1

0

Small-scale

0.458

High

162975

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.458

High

162964

TCAB1
Telomerase Cajal body protein 1

1

0

Small-scale

0.426

High

162885

PFD1
Prefoldin subunit 1

1

0

Small-scale

0.251

Low

162933

TBA1B
Tubulin alpha-1B chain

1

0

Small-scale

0.251

Low

162966

TIM21
Mitochondrial import inner membrane translocase subunit Tim21

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025