Protein: COX6C
Cytochrome c oxidase subunit 6C (Cytochrome c oxidase polypeptide VIc)

Gene: COX6C
Organism: Homo sapiens
Interactions: 105
UniProt ID: P09669

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005758 - mitochondrial intermembrane space
GO:0006091 - generation of precursor metabolites and energy
GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

485831

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

4

2

High-throughput

0.886

High

485839

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

2

0

Small-scale

0.699

High

485878

CX7B2
Cytochrome c oxidase subunit 7B2, mitochondrial

1

2

High-throughput

0.691

High

485884

COX42
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

1

2

High-throughput

0.691

High

485843

COX7B
Cytochrome c oxidase subunit 7B, mitochondrial

1

2

High-throughput

0.618

High

360363

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.586

High

485867

SURF1
Surfeit locus protein 1

2

0

Small-scale

0.547

High

485909

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

2

0

Small-scale

0.547

High

485846

PHB1
Prohibitin 1

1

0

High-throughput

0.537

High

485850

HD
Huntingtin

2

1

High-throughput

0.537

High

485829

CX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial

1

1

High-throughput

0.536

High

485842

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

1

High-throughput

0.536

High

485866

KPCD1
Serine/threonine-protein kinase D1

2

1

High-throughput

0.521

High

485837

COX7C
Cytochrome c oxidase subunit 7C, mitochondrial

1

0

High-throughput

0.513

High

485905

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

0

High-throughput

0.513

High

137625

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.479

High

292059

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

4

High-throughput

0.479

High

348326

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.479

High

424736

ADT2
ADP/ATP translocase 2

1

4

High-throughput

0.479

High

485824

COX6C
Cytochrome c oxidase subunit 6C

1

1

High-throughput

0.479

High

485830

ADT3
ADP/ATP translocase 3

1

4

High-throughput

0.479

High

485833

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

1

High-throughput

0.479

High

485873

MIC27
MICOS complex subunit MIC27

1

1

High-throughput

0.479

High

485879

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

1

1

High-throughput

0.479

High

485889

MIC26
MICOS complex subunit MIC26

1

1

High-throughput

0.479

High

485895

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

5

High-throughput

0.479

High

485910

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

1

High-throughput

0.479

High

216612

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

274965

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

275236

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.458

High

283772

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.458

High

485825

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

485834

CX6B1
Cytochrome c oxidase subunit 6B1

1

0

High-throughput

0.458

High

485845

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

High-throughput

0.458

High

485854

KAD2
Adenylate kinase 2, mitochondrial

1

0

High-throughput

0.458

High

485856

ROMO1
Reactive oxygen species modulator 1

1

0

High-throughput

0.458

High

485869

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

485881

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

485883

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.458

High

485885

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

0

High-throughput

0.458

High

485886

IMP1L
Mitochondrial inner membrane protease subunit 1

1

0

High-throughput

0.458

High

485888

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

485893

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

485896

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

485897

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

485899

D39U1
Epimerase family protein SDR39U1

1

0

High-throughput

0.458

High

485900

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

485901

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

485906

STML2
Stomatin-like protein 2, mitochondrial

1

0

High-throughput

0.458

High

462753

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

1

High-throughput

0.445

High

485861

CX6A2
Cytochrome c oxidase subunit 6A2, mitochondrial

1

1

Small-scale

0.445

High

485836

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

485855

KLF3
Krueppel-like factor 3

1

1

High-throughput

0.437

High

485862

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.437

High

328348

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

0

Small-scale

0.426

High

360242

COX1
Cytochrome c oxidase subunit 1

1

0

Small-scale

0.426

High

485826

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.426

High

485827

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

485835

QCR7
Cytochrome b-c1 complex subunit 7

1

0

High-throughput

0.426

High

485853

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

Small-scale

0.426

High

485870

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

485890

TIM21
Mitochondrial import inner membrane translocase subunit Tim21

1

0

Small-scale

0.426

High

485860

S35B1
Solute carrier family 35 member B1

1

1

High-throughput

0.407

High

485865

S39AE
Metal cation symporter ZIP14

1

2

High-throughput

0.407

High

485877

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

1

High-throughput

0.407

High

485880

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.407

High

485894

S39A8
Metal cation symporter ZIP8

1

2

High-throughput

0.407

High

485907

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.407

High

485859

RAC1
Ras-related C3 botulinum toxin substrate 1

2

0

High-throughput

0.328

High

485841

SAT1
Diamine acetyltransferase 1

2

0

High-throughput

0.316

High

436585

KPCB
Protein kinase C beta type

2

0

High-throughput

0.298

High

485840

PTN
Pleiotrophin

1

0

High-throughput

0.282

High

165888

FFAR1
Free fatty acid receptor 1

1

0

High-throughput

0.279

Low

485851

CRK
Adapter molecule crk

1

0

High-throughput

0.279

Low

485852

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.279

Low

485857

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.279

Low

485892

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

485902

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.279

Low

485848

SOX6
Transcription factor SOX-6

1

0

High-throughput

0.261

Low

485891

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.261

Low

485887

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.251

Low

178158

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.249

Low

222659

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.249

Low

485828

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.249

Low

485832

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.249

Low

485838

NELFE
Negative elongation factor E

1

0

High-throughput

0.249

Low

485844

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

485847

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

485849

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

485858

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

485868

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

485875

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.249

Low

485876

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.249

Low

485898

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low

485903

DYH2
Dynein axonemal heavy chain 2

1

0

High-throughput

0.249

Low

485904

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

189972

MOT7
Monocarboxylate transporter 7

1

0

High-throughput

0.232

Low

485863

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low

485864

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.232

Low

485871

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

485872

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.232

Low

485874

S35E3
Solute carrier family 35 member E3

1

0

High-throughput

0.232

Low

485882

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.232

Low

485908

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025