Protein: PTPS
6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS) (EC 4.2.3.12)

Gene: PTPS, PTS
Organism: Homo sapiens
Interactions: 47
UniProt ID: Q03393

Gene Ontology (top 5):
GO:0003874 - 6-pyruvoyltetrahydropterin synthase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0006520 - amino acid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1042576

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

11

4

Small-scale

0.982

High

140234

SDCB1
Syntenin-1

2

0

High-throughput

0.601

High

900283

FXR2
RNA-binding protein FXR2

2

0

High-throughput

0.593

High

1042593

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.593

High

1042591

AP2M1
AP-2 complex subunit mu

2

0

High-throughput

0.580

High

1042592

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

1042587

LNX1
E3 ubiquitin-protein ligase LNX

1

0

High-throughput

0.549

High

440037

LCK
Tyrosine-protein kinase Lck

2

0

High-throughput

0.547

High

1042578

MK07
Mitogen-activated protein kinase 7

2

0

High-throughput

0.547

High

1042590

ARHG1
Rho guanine nucleotide exchange factor 1

2

0

High-throughput

0.547

High

1042584

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.513

High

1042597

AGO4
Protein argonaute-4

1

0

High-throughput

0.513

High

1042602

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

1042603

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.513

High

193258

SOCS1
Suppressor of cytokine signaling 1

1

1

Small-scale

0.479

High

1042589

ASB5
Ankyrin repeat and SOCS box protein 5

1

1

High-throughput

0.479

High

1042601

ASB1
Ankyrin repeat and SOCS box protein 1

1

1

High-throughput

0.479

High

257450

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

293590

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

319691

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

349044

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

395957

ESR1
Estrogen receptor

1

0

High-throughput

0.458

High

957334

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

970368

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1042577

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

1042580

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.458

High

1042581

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1042585

GOLI
E3 ubiquitin-protein ligase RNF130

1

0

High-throughput

0.458

High

1042596

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

0

High-throughput

0.458

High

1042599

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

529668

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

1025535

CDK16
Cyclin-dependent kinase 16

1

0

Small-scale

0.438

High

1042582

T2H2L
General transcription factor IIH subunit 2-like protein

3

0

High-throughput

0.347

High

1042586

TEX29
Testis-expressed protein 29

3

0

High-throughput

0.347

High

469475

SYPH
Synaptophysin

2

0

High-throughput

0.328

High

1042594

TAFA4
Chemokine-like protein TAFA-4

2

0

High-throughput

0.328

High

799859

COIL
Coilin

1

0

High-throughput

0.299

High

1042598

THA10
THAP domain-containing protein 10

1

0

High-throughput

0.299

High

345173

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.279

Low

1042579

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.279

Low

1042583

ZFP1
Zinc finger protein 1 homolog

1

0

High-throughput

0.279

Low

1042588

FNDC8
Fibronectin type III domain-containing protein 8

1

0

High-throughput

0.279

Low

1042595

CIC
Protein capicua homolog

1

0

High-throughput

0.249

Low

1042600

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

388776

C1QC
Complement C1q subcomponent subunit C

1

0

High-throughput

0.238

Low

906261

GPC3
Glypican-3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025