Protein: EME1
Structure-specific endonuclease subunit EME1 (Crossover junction endonuclease EME1) (Essential meiotic structure-specific endonuclease 1) (MMS4 homolog) (hMMS4)

Gene: EME1
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q96AY2

Gene Ontology (top 5):
GO:0000712 - resolution of meiotic recombination intermediates
GO:0000792 - heterochromatin
GO:0003677 - DNA binding
GO:0004519 - endonuclease activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1383747

MUS81
Structure-specific endonuclease subunit MUS81

18

3

Small-scale

0.987

High

1314349

SLX4
Structure-specific endonuclease subunit SLX4

7

0

Small-scale

0.721

High

422819

A4
Amyloid-beta precursor protein

3

0

High-throughput

0.642

High

1314866

FANCM
Fanconi anemia group M protein

1

2

Small-scale

0.618

High

1369956

XPF
DNA repair endonuclease XPF

1

2

Small-scale

0.618

High

1253605

I23O2
Indoleamine 2,3-dioxygenase 2

2

0

High-throughput

0.602

High

1383751

SLX1
Structure-specific endonuclease subunit SLX1

2

0

Small-scale

0.592

High

964411

SUMO2
Small ubiquitin-related modifier 2

2

0

Small-scale

0.577

High

1383757

NGN3
Neurogenin-3

2

1

High-throughput

0.574

High

343001

HERC2
E3 ubiquitin-protein ligase HERC2

2

0

High-throughput

0.547

High

682569

S100P
Protein S100-P

1

1

High-throughput

0.536

High

1163125

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.515

High

1372257

H2B1H
Histone H2B type 1-H

1

2

High-throughput

0.515

High

340381

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.513

High

648374

USF1
Upstream stimulatory factor 1

1

0

High-throughput

0.513

High

714334

PML
Protein PML

1

0

High-throughput

0.513

High

824276

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.513

High

859017

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

1027650

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.513

High

1191460

GRDN
Girdin

1

0

High-throughput

0.513

High

1316954

FAM9B
Protein FAM9B

1

0

High-throughput

0.513

High

1383748

INT14
Integrator complex subunit 14

1

0

High-throughput

0.513

High

706252

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

1157854

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.480

High

558998

LYL1
Protein lyl-1

1

1

High-throughput

0.479

High

980994

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

1383749

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

1

Small-scale

0.479

High

593183

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.458

High

799376

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

912995

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

0

High-throughput

0.458

High

920174

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

980108

H4
Histone H4

1

0

High-throughput

0.458

High

1045613

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1338884

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.458

High

1366818

RAD54
DNA repair and recombination protein RAD54-like

1

0

Small-scale

0.458

High

1383746

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

814557

FEN1
Flap endonuclease 1

1

1

Small-scale

0.445

High

1140668

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

1383745

RBM33
RNA-binding protein 33

3

0

High-throughput

0.347

High

1383756

KLK5
Kallikrein-5

3

0

High-throughput

0.347

High

142225

CCL22
C-C motif chemokine 22

2

0

High-throughput

0.328

High

191736

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.279

Low

1322771

CNTRB
Centrobin

1

0

High-throughput

0.279

Low

1341363

KI18A
Kinesin-like protein KIF18A

1

0

High-throughput

0.279

Low

1364785

TICN2
Testican-2

1

0

High-throughput

0.279

Low

1381155

SNX21
Sorting nexin-21

1

0

High-throughput

0.279

Low

1383750

SORT
Sortilin

1

0

High-throughput

0.279

Low

1383752

PAR6B
Partitioning defective 6 homolog beta

1

0

High-throughput

0.279

Low

1383753

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

High-throughput

0.279

Low

1383755

INTU
Protein inturned

1

0

High-throughput

0.279

Low

1383754

XPO7
Exportin-7

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025